25 May 2022
Researchers at Kanazawa University in collaboration with teams from Toyama Prefectural University and BioSeeds Corporation report in ACS Applied Materials & Interfaces the identification of a molecule with enhanced antiproliferative activity in cancer cells. The underlying biomolecular mechanism is the inhibition of an enzyme that is overproduced in several types of cancer.
26 Apr 2022
Researchers set out to find new ways to artificially induce mRNA to respond in ways that could eventually lead to therapeutic outcomes, expanding on the success of the mRNA-based COVID-19 vaccines and opening up new possibilities across a host of possible genetic therapies.
25 Apr 2022
Examination of endangered species’ stem cells unveils ancient genetic links between mammals.
16 Feb 2022
This is a novel study that attempted to construct a pH-sensitive delivery system into T cells and their subsets using carboxy-terminal Phe- and CHex-modified dendrimers with different structures, i.e. PAMAM-CHex-Phe and PAMAM-Phe-CHex. The findings contribute to the development of nanoplatforms for direct delivery to T cells to control the functions of T cells, which play key roles in cancer immunotherapy. This is the first report on direct delivery into T cells using pH-sensitive DDS.
31 Jan 2022
Garden soil houses a variety of bacteria and their natural byproducts — including one that may help halt tumor growth. Lankacidins are molecules that can be isolated from Strepomyces rochei, a common bacterium in soil. In addition to antimicrobial properties, a type of lankacidins, called lankacidin C, can inhibit tumor activity in various cancer cell lines, including leukemia, melanoma, ovarian and breast cancers. Lankacidin C offers a potential foundation on which to design anticancer drugs, but its structure is complicated and difficult to manipulate, according to an international research group. The same group recently identified where antitumor activity is housed on the molecule and has now used that information to simplify lankacidin as a potential starting point to engineer treatments.
24 Jan 2022
Researchers from Hokkaido University have proposed a framework to assist in the demarcation between genetically modified organisms and genome-edited organisms, taking into account both scientific and socio-ethical considerations.
06 Jan 2022
Enzymatic hydrolysis of planteose: α-Galactosidase is a promising molecular target for root parasitic weed control
13 Oct 2021
Coral reefs, comprising some of the most diverse and delicate ecosystems under water, are under immense stress. From global warming to pollution to pathogens, many of the reef-building coral species are listed as threatened or endangered. But, according to researchers in Japan, the corals may have an unlikely ally: bacteria.
30 Sep 2021
Geb Impact aims to scale up microalgae production to provide novel super food ingredient by cost-effective mass cultivation of microalgae
14 Sep 2021
When it comes to cancer, clarity is key. The ability to visualize cancerous tumors and metastatic tissue three dimensionally (3D) can help clinicians diagnose the precise type and stage of cancer, while also informing the best treatment methods. To obtain an even clearer tissue for imaging, a research team based in Japan has tested the effectiveness of specialized hydrogels. Acting as a 3D molecular network, these hydrogels can rapidly remove fats from tissues, which are a factor in tissue opacification, without losing their structure. The material is used in several biomedical devices, including contact lenses.
02 Sep 2021
Researchers at Kanazawa University describe in Scientific Reports the identification of small compounds that can regulate the cellular production of extracellular vesicles — nanocontainers transporting biomolecules between cells. Such compounds hold promise for use in therapies for various diseases.
26 Aug 2021
A multi-functional, small molecule can tag mutant genetic sequences inside mitochondria for removal.
20 Aug 2021
A microphysiological system (MPS) is a 3D organ construct using human cells. They show us how organs respond to drugs and environmental stimuli. Now, Tohoku University researchers have developed a new imaging tool for MPS using scanning probe microscopy.
17 Aug 2021
Cells translate their genetic material at rapid rates with exquisite precision to reproduce, repair damage or even combat disease. But the process can deregulate and give rise to disease. Byproducts of errant processes can build up like gunk in the gears, especially around neurons, breaking down the repair mechanisms and causing further damage and even neurodegenerative disorders such as Alzheimer’s disease.
15 Jul 2021
Scientists have developed a rapid, highly accurate test to detect antibodies against the spike protein of SARS-CoV-2 in human serum, opening a new avenue for understanding the full extent of the pandemic and evaluating the effectiveness of vaccines.
08 Jul 2021
Researchers at The University of Tokyo Institute of Industrial Science use artificial intelligence to predict the size of cells over time without the need for simplifying assumptions, which may lead to a new understanding of microbiology principles and improved drug manufacturing from recombinant bacteria
09 Jun 2021
Publication bias, or the tendency of researchers and journals to not publish uninteresting findings, plagues much of the natural sciences and especially biomedical research. Hiroshima University researchers have developed a meta-analytic technique exploiting publicly available transcriptome databases that avoids the problem—and in so doing, discovered four genes previously unknown to be associated with responding to low-oxygen stress.
13 May 2021
A spray-on magnetic coat turns any object into a robot controlled by a magnetic field. The biocompatible robots can walk, crawl and roll, and switch motions on demand.
13 May 2021
A spinning toy meets hydrodynamics and sets point-of-care diagnostics in motion.
12 May 2021
Acetone, a volatile solvent used for everything from removing nail polish and cleaning textiles to manufacturing plastics, could get a sustainability boost from a new strain of bacteria engineered by a research team based in Japan.
10 Mar 2021
Researchers at The University of Tokyo use the mathematics of adaptive learning and artificial intelligence to describe how T helper cells adjust the response of the vertebrate immune system, which may lead to new vaccines and treatments for infections
02 Mar 2021
Researchers at The University of Tokyo develop a method of culturing meat in the laboratory in the form of millimeter-scale contractile beef muscle that closely simulates steak meat
19 Feb 2021
An international team led by Professor Yilin Wu, Associate Professor of the Department of Physics at The Chinese University of Hong Kong (CUHK) has made a novel conceptual advance in the field of active matter science. The team discovered a new route in which the self-organisation of active fluids in space and time can be controlled by a single material property called viscoelasticity. This new finding may pave the way for fabricating a new class of self-driven devices and materials, such as the ability to control the rhythmic movement of soft robots without relying on electronic circuits, and for the study of microbial physiology. It has been published in the scientific journal Nature.
19 Feb 2021
Undergraduate students explore a more efficient way to measure protein-containing vessels released by cells
17 Feb 2021
Researchers from DGIST have now found a way to keep living, wet cells viable in an ultra-high-vacuum environment, using graphene, allowing—like never before—accurate high-resolution visualization of the undistorted molecular structure and distribution of lipids in cell membranes. This could enhance our bioimaging abilities considerably, improving our understanding of mechanisms underlying complex diseases such as cancers and Alzheimer’s
10 Feb 2021
In a study published in Gastroenterology – Researchers at Osaka City University and The Institute for Medical Science, The University of Tokyo, in collaboration with Brigham and Women's Hospital in Boston, report the intestinal bacterial and viral metagenome information from the fecal samples of patients with recurrent Clostridioides difficile infection (rCDI). This comprehensive analysis reveals the bacteria and phages involved in pathogenesis in rCDI, and their remarkable pathways important for the recovery of intestinal flora function.
09 Feb 2021
Tissue stem cells can self-renew and differentiate, supplying cells necessary for tissues at various developmental stages. However, detailed analysis in vivo is difficult, so the molecular mechanisms underlying the stemness of gastric tissue stem cells have remained a mystery. Here, by using organoids that mimic tissue structure and function in vivo and GeCKO screening to inactivate arbitrary genes, Alk, Bclaf3 and Prkra have been identified as genes regulating stemness.
19 Jan 2021
New ‘armoured’ T cells attack cancer without being suppressed by drugs given to transplant patients to avoid organ rejection.
15 Jan 2021
A research group compared how crickets adapt to limb removal, revealing more about adoptive locomotion and the mechanisms underpinning it.
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Department of Microbiology / Biomolecular Sciences Universiti Teknologi MARA Malaysia
Dr. Wookbong Kwon is currently a postdoctoral researcher at the Division of Biotechnology of Daegu Gyeongbuk Institute of Science and Technology (DGIST)
Assistant Professor and Head Department of Environmental Science Dr. D. Y. Patil Unitech Society's Dr. D. Y. Patil Arts, Commerce and Science College, Pimpri, Pune 411018
Ana Carina Manjua's current PhD work is in the design and fabrication of a biological inspired artificial microfluid platform for drug screening.
Frederico Castelo Ferreira's current research interest balances between fundamental and applied research, with potential translation into the market of sustainable products and processes.
Dr. Tengku Haziyamin Tengku Abdul Hamid's recent discovery of a novel strain has enabled a new patent to be drafted and was awarded gold medal in Malaysian Technology Expo 2021 for his new probiotic prototype called ProAquaVcare.
Associate Professor Hajin Kim is a biomedical engineer at the Single Molecule Biophysics Laboratory, Ulsan National Institute of Science and Technology, South Korea.
Yoon-Kyoung Cho is currently a group leader in the Center for Soft and Living Matter at the Institute for Basic Science (IBS) and a full professor in the Department of Biomedical Engineering at Ulsan National Institute of Science and Technology (UNIST) in the Republic of Korea.
Aparna B. Gunjal is a microbiologist at Dr. D.Y. Patil, Arts, Commerce & Science College, India.
Michitaka Notaguchi is an assistant professor at the Bioscience and Biotechnology Center, Nagoya University, Japan.