Nature

Osaka University researchers discovered liver resident macrophages' pivotal role in defending against gut bacteria and related substances entering via the portal vein, particularly under compromised intestinal barrier conditions. Identified as "sentinel macrophages," they are activated by isoallo-lithocholic acid. This finding holds promise for developing preventive and therapeutic strategies for liver chronic inflammatory diseases, such as metabolic dysfunction-associated steatohepatitis (MASH), by enhancing the function of these macrophages to mitigate inflammation and improve treatment efficacy.

Species living in 17 mountains around the world are facing the risk of extinction due to the rapid rate of warming attributed to climate change. However, the establishment of additional meteorological monitoring stations in mountainous areas globally is essential for a deeper understanding of the extent of these threats.

Researchers from Monash University and Osaka University have unveiled a groundbreaking discovery regarding the pivotal role of sensory neurons in orchestrating tissue repair and regeneration, offering significant promise for patients with poorly healing tissues and diabetes.

At least one in a dozen stars show evidence of planetary ingestion according to a paper published in Nature today.

A research team led by City University of Hong Kong (CityU) has achieved a groundbreaking advancement in nanomaterials by successfully developing a highly efficient electrocatalyst which can enhance the generation of hydrogen significantly through electrochemical water splitting.

Research published today in Nature warns that rising seas will devastate coastal habitats, using evidence from the last Ice Age.

Researchers from Northwestern University and recently joining the Institute for Industrial Science, The University of Tokyo develop a high-throughput approach to evaluate protein folding stability in thousands of proteins .

New technological development has provided further clues about the origins of life on Earth. An international research group invented an innovative X-ray spectroscopy approach that enabled them to recreate the chemical reactions occurring in liquids at the femtosecond level (a quadrillionth part of a second). They used this to examine ureas—an organic compound that underwent ionization to form some of the building blocks of life.

For the first time, the James Webb Space Telescope has revealed starlight from two massive galaxies hosting actively growing black holes – quasars – seen less than a billion years after the Big Bang.

地球外生命が発見されれば、宇宙における私たちの存在意義に変化をもたらすだろう。しかしその探索に関する報道の在り方は、科学者やメディアにとって未だに大きな課題である。

Finding extra-terrestrial life would transform how we view our place in the Universe, but reporting on the search for it poses challenges for scientists and the media.

In hepatic steatosis, hepatocytes "die," resulting in liver damage. Severe steatosis increases hepatocellular deaths, thus aggravating liver damage. The mechanism is unclear. Using mice, we show that mild steatosis causes apoptosis whereas severe steatosis predominantly causes necroptosis leading to cell rupture. This induces strong inflammation and new cell death, producing further liver damage. We reveal the transcription factor ATF3 to be involved in this process. Our results are expected to contribute to therapeutic method development.

A flipping action in a porous material facilitates the passage of normal water to separate it out from heavy water.

Puzzling image from the James Webb Space Telescope explained in two new studies

Researchers from Osaka University and collaborating partners used common nanofabrication procedures to fabricate versatile metal semiconductor superlattices. These superlattices exhibit a long-sought physical phenomenon—the anisotropic anomalous Hall effect at room temperature. This research will help improve the density of data storage, as well as the functionality of other technologies that also depend on advances in the microelectronics industry.

Researchers have discovered that vitamin K acts as a powerful antioxidant. It can inhibit ferroptosis, a type of cell death associated with Alzheimer’s disease and organ damage, by trapping lipid radicals. Furthermore, the team identified the long-sought-after vitamin K-reducing enzyme, the identity of which remained unknown for more than half a century.

Metals usually soften when they expand under heating, but a research team led by a City University of Hong Kong (CityU) scholar and other researchers have discovered a first-of-its-kind super-elastic alloy that can retain its stiffness even after being heated to 1,000K (about 727℃) or above, with nearly zero energy dissipation. The team believes that the alloy can be applied in manufacturing high-precision devices for space missions. The research team was led by Professor Yang Yong from CityU’s Department of Mechanical Engineering (MNE), together with his collaborators. The findings were published in the prestigious science journal Nature under the titled “A Highly Distorted Ultraelastic Chemically Complex Elinvar Alloy”.

A research team led by scientists from City University of Hong Kong (CityU) has recently designed a structured thermal armour (STA) that achieves efficient liquid cooling even over 1,000°C, fundamentally solving a 266-year-old challenge presented by the Leidenfrost effect. This breakthrough can be applied in aero and space engines, as well as improve the safety and reliability of next-generation nuclear reactors.

Dozens of researchers tell Nature they have received death threats, or threats of physical or sexual violence.

Climate change may lead to a modest net reduction in global annual energy expenditures by the end of the 21st century, according to a study published in Nature.

KAIST researchers have used whole-genome sequencing to track the development from a single fertilized-egg to a human body.

Cryo-electron microscopy and computer simulations uncover how a cellular protein helps transport omega-3 fatty acids to the brain and eye, with implications for drug development.

Revelations from a fly study could improve our understanding of protein malnutrition in humans.

A new device can light up 100 LED bulbs with a single drop of water.

In the era of Artificial Intelligence (AI), a novel optical “micro-comb” chip developed by a physicist from the City University of Hong Kong (CityU) has played a pivotal role in building the fastest optical neural network processor. An international research team has recently demonstrated the world’s fastest and most powerful optical neural network processor, which is capable of operating at faster than 10 trillion operations per second. When applied to handwritten digital recognition, a common benchmark in AI, it achieved an accuracy of nearly 90%. It represents an enormous leap forward for neural networks and neuromorphic processing.

A study by KAIST researchers revealed that an ionized gas jet blowing onto water, also known as a ‘plasma jet’, produces a more stable interaction with the water’s surface compared to a neutral gas jet. This finding reported in the April 1 issue of Nature will help improve the scientific understanding of plasma-liquid interactions and their practical applications in a wide range of industrial fields in which fluid control technology is used, including biomedical engineering, chemical production, and agriculture and food engineering.

Many genetic variants have been found to have a linkage with genetic diseases, but the understanding of their functional roles in causing diseases are still limited. An international research team, including a biomedical scientist from City University of Hong Kong (CityU), has developed a high-throughput biological assay technique which enabled them to conduct a systematic analysis on the impact of nearly 100,000 genetic variants on the binding of transcription factors to DNA. Their findings provided valuable data for finding key biomarkers of type 2 diabetes for diagnostics and treatments. And they believe that the new technique can be applied to studies of variants associated with other genetic diseases.

An international team led by Professor Yilin Wu, Associate Professor of the Department of Physics at The Chinese University of Hong Kong (CUHK) has made a novel conceptual advance in the field of active matter science. The team discovered a new route in which the self-organisation of active fluids in space and time can be controlled by a single material property called viscoelasticity. This new finding may pave the way for fabricating a new class of self-driven devices and materials, such as the ability to control the rhythmic movement of soft robots without relying on electronic circuits, and for the study of microbial physiology. It has been published in the scientific journal Nature.

It’s not only climate change impacting bird reproduction.

A recent study, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has demonstrated that in the presence of polymers (preferably, polyionic liquids), crystals of various types grow in common solvents, at constant temperature, much bigger and much faster when stirred, rather than kept still.