Peer Reviewed

The costliness of drug development and the limitations of studying physiological processes in the lab are two separate scientific issues that may share the same solution. Microphysical systems (MPSs) are in vitro platforms made up of cells in a microenvironment that closely mimics that found in the body, allowing scientists to recreate the conditions of tissues found within the body for both further elucidation of biological conditions and systems and for applications such as testing drugs in a more precise model than animal testing allows. However, the advancements that MPSs could provide have been limited up to this point by an inability to accurately record what is happening at a cellular level. Now, a team of scientists has developed an electrochemical sensing platform that could solve this issue. The results were published in Biosensors and Bioelectronics.

Osaka Metropolitan University scientists have discovered that, in the crystalline solid Ba1-xSrxAl2O4, a highly disordered atomic arrangement is formed in the AlO4 network at chemical compositions near the structural quantum critical point, resulting in characteristics of both crystalline and amorphous materials. This hybrid state, which the research team was the first to discover, can be created simply by mixing raw materials uniformly and heating them. These findings are expected to help with the development of hybrid materials for use in harsh environments, such as outer space, by applying the technique to a variety of materials.

Comprehensive characterization of halogenated flame retardants and organophosphate esters in settled dust from informal e-waste and end-of-life vehicle processing sites

With the shift to electric cars a cumbersome process, improvements to exhaust gas purification in petrol or diesel cars are crucial in the fight to reduce emissions. A research group at Tohoku University’s Graduate School of Engineering has developed a Cerium-Zirconium-based oxide that boosts the purifying qualities of ceramics inside catalytic converters - a device attached to conventional cars that converts harmful gases to less-toxic pollutants.

Researchers led by Osaka University show that a molecule called T-cadherin can be secreted in a soluble form. Soluble T-cadherin interacts with pancreatic insulin-producing β cells via the Notch signaling pathway to promote their proliferation and increase the production of insulin. Recombinant T-cadherin stimulated Notch signaling in isolated mouse pancreatic islets, which contain β cells, indicating that T-cadherin may have therapeutic potential for diabetes.

Scientists in Japan have combined two computational models to extract more data on steel alloys from a single test, with implications for the discovery of new materials.

Research in Singapore confirms a link between tiny particulates in air pollution and sudden cardiac arrests in the general population.

Groundwater is considered both an environmental and industrial resource, but a new study indicates it is also an important resource in disaster prevention. Osaka Metropolitan University researchers conducted research surveys of 91 well owners and 328 welfare facilities affected by the 2016 Kumamoto Earthquake. The surveys clarified groundwater use following the earthquake and policy issues that could make the use of emergency wells more effective in the wake of future disasters. The surveys’ findings provide useful data for city governments that have installed or are considering installing emergency wells.

Researchers from Osaka University have demonstrated a proof-of-concept for a novel use of artificial intelligence for enzyme engineering that does not require an enzyme’s crystal structure. By analyzing the amino acid sequences of malic enzymes from various living organisms, the researchers identified the amino acids that are pertinent to using different redox cofactors. The results of this work will facilitate retooling enzymes in research laboratories and the biotech industry.

Scientists in Singapore show that restoring natural water availability to the Mekong’s floodplains is possible

As our brains develop, cells within it ‘eat’ neuronal elements to clear out debris, pathogens and help improve efficiency. A recent study showed that motor learning in mice helped enhance the engulfing of synapses by Bergmann glial cells. The discovery could have possible implications for explaining why synaptic shrinkage and loss occur in depression, schizophrenia, and Alzheimer’s disease.

Triple-negative breast cancer (TNBC) tumors gain immunosuppression and chemoresistance through interactions between interleukin 34 and myeloid-derived suppressor cells, researchers find.

A research group at Osaka Metropolitan University has developed a drug delivery system that activates a strong cellular immune response to attack cancer cells, using one-tenth of the amount of antigen needed in the group’s previous work. By incorporating positively charged cationic lipids into liposomes and adding negatively charged pH-responsive polysaccharides to the surface, the research group increased the uptake efficiency of liposomes encapsulating cancer antigens by dendritic cells by approximately five times, which increased cytokine production by about 100 times. This increased M1-type macrophages, which activate cancer immunity, and decreased M2-type macrophages, which promote cancer growth.

While both protect from severe disease, inactivated SARS-CoV-2 and spike mRNA vaccines trigger different T-cell responses.

Researchers from Osaka University used a combination of genetic manipulation and protein structural analysis to determine how the position of “bulky” amino acids influences the ability of efflux pump inhibitors to bind bacterial pump proteins and so reduce their resistance to antibiotics. This work has implications for our understanding of bacterial antibiotic resistance, and may be useful in the rational design of drugs that target bacteria that have evolved antibiotic resistance.

New research identifies a unique way that people find connection in the modern world and provides novel insight into the fields of anthropomorphism, virtual interactions, and relationship science.

Osaka Metropolitan University scientists conducted a 7-year study on seedling recruitment and mortality in a national park in Chiang Mai, in northern Thailand. During the study period, an extremely strong El Niño event occurred, leading to a stronger and longer drought than normal. Seasonally dry tropical forests (SDTFs), which experience an annual dry season, are considered drought-tolerant. Nevertheless, the study found that seedling mortality increased in SDTFs when severe and prolonged drought occurred. The mortality rate was greater in evergreen forests at higher elevations that usually experience less severe drought than in deciduous forests at lower elevations where severe drought is more common. The study results advance the understanding of the effects of El Niño on seedling dynamics in SDTFs.

When two neutron stars merge, the resultant explosion forms heavy elements—many of which make up our Universe. A new study has, for the first time, identified the specific rare-earth elements produced in a neutron star merger.

Researchers from Osaka University have demonstrated a proof-of-concept for a novel molecular hydrogen production method that bypasses the need for expensive purification steps. They developed a system where hydrogen is separated and stored in liquid organic hydrogen carriers by catalysis of triaryl boranes in one seamless process. The results of this work will help facilitate the transition to a hydrogen-based economy that is necessary for a more sustainable future.

Plastic sheets coated with an Eu3+ film that converts UV light to red light were able to accelerate growth of vegetal plants and trees.

Researchers from Osaka University have shown that deficiency of the protein Favine can lead to accelerated development of atherosclerosis. Loss of Favine in a mouse atherosclerosis model also led to calcification and thrombus development in the blood vessels of the mice. Prior to this, no mouse models for calcification or thrombus formation existed, hindering atherosclerosis research. This work also identifies Favine and its downstream signaling pathway, known as MEF2C-KLF2, as potential therapeutic targets for atherosclerosis.

Researchers from The Institute of Scientific and Industrial Research (SANKEN) at Osaka University and collaborating partners prepared hierarchical hydrogels and moldings that consisted of anisotropic, ecofriendly cellulose nanofibers. By simply tailoring the applied voltage during fabrication, complex architectures—such as microneedles and multilayer hydrogels—were easy to prepare. The results of this work will reduce the need for petroleum-based plastics, and in so doing minimize a long-standing source of environmentally persistent waste.

Making complex polymers with precisely controlled structures becomes much simpler thanks to a new ‘one-pot-and-one-step’ synthesis procedure.

Investigations in Japan have uncovered some molecular mechanisms behind mitochondrial dysfunction in chronic heart failure.

An Osaka Metropolitan University researcher has provided a review article regarding INSL3, a circulating hormone secreted from the gonads, in domestic animals, in comparison to rodents and humans. In this review article, the author describes his research group’s work that (1) developed immunoassays, for the first time, that can measure circulating INSL3 in multiple domestic mammals, including cattle, goats, sheep, pigs, horses, and dogs, (2) provided evidence in studies with bulls and bucks that INSL3 offers more reliable and stable values by a single blood collection than testosterone, a conventional and well-known testicular hormone, and (3) suggested that blood INSL3 concentrations would be a good biomarker for testicular and reproductive functions in normal and abnormal male domestic animals. These findings suggest that the INSL3 assay might simplify the evaluation of reproductive functions in various male domestic animals. In particular, the assay method may facilitate earlier selection of valuable male animals such as beef sire bulls (Image) with higher reproductive performance, contributing to reductions in the labor and costs required for sire production.

Osaka University researchers showed that the predictions of Einstein’s theory of special relativity in electromagnetism could be detected in the contraction of the electric field created by ultrafast electrons. By achieving femtosecond resolution, they were able to visualize the contracted electric field for the first time. This work can be applicable to particle accelerators and high-energy physics.

Pyroxenes are a major group of rock-forming minerals. Osaka Metropolitan University scientists investigated the iron ion status of a calcium-rich pyroxene, using Mössbauer spectroscopy on thin sections of single crystals. The study revealed that in pyroxene crystals consisting of roughly 50% calcium, the tensor that determines the ratios of iron ions at the Mössbauer spectral peaks in the M1 sites—one of two types of cation positions in the pyroxene crystal structure—is independent of the iron content but dependent on the calcium content. The research findings have clarified one of the physical properties of pyroxenes, facilitating detailed future analysis of iron using Mössbauer spectroscopy on mineral flakes.

Osaka Metropolitan University researchers interviewed active para-athletes with lower-limb disabilities who compete at an international level, about diet and nutrition. The research team found that what para-athletes considered an ideal diet was not necessarily optimized for improving athletic performance, and even when para-athletes understood diets geared towards athletic performance, characteristics of their disabilities impose barriers to implementing dietary changes. Understanding these concerns and struggles is important for nutritionists who support para-athletes in sports nutrition.

New insights into the role of a protein in the nerve cells of flies could help unravel the role of a related human protein in common cancers.

Scientists have uncovered new details of how ice forming below the ocean surface in Antarctica provides cold dense water that sinks to the seabed in an important aspect of global water circulation.