Peer Reviewed

New findings from a cave in northern Laos add to a growing body of evidence that modern humans arrived in Southeast Asia over 80,000 years ago, tens of thousands of years earlier than previously thought.

A New Approach for Peripheral Annelation of Porphyrinoid

Researchers from Osaka University analyzed discussions on research governance of human genome editing in the Expert Panel on Bioethics in Japan and identified the positive roles played by related research communities, the government, and the general public in the policy-making process. It is expected to provide more effective and practical guidance for countries and organizations seeking to work with diverse stakeholders in the governance of emerging medical technologies.

Researchers from Osaka University have revealed the mechanism by which increased signaling through a pathway associated with a molecule called Wnt leads to the development of liver cancer. They identified a gene called GREB1 as a target of Wnt specifically in liver cancer. This gene alters the function of a protein called HNF4α, leading to the development of cancer. They also showed that treatment of mice with antisense oligonucleotides against GREB1 had significant anti-cancer effects.

Have you ever studied hard for a test the night before, only to fail miserably the next day? Alternatively, you may have felt unconfident after studying the night before when, to your astonishment, you recall effortless the content on test day. This discrepancy may be down to the separate and independent way in which our brain processes short- and long-term memory, Tohoku University researchers have revealed.

Researchers from the Institute of Industrial Science (The University of Tokyo) have developed a high-resolution method for climate model simulation.

Researchers from SANKEN (The Institute of Scientific and Industrial Research), at Osaka University demonstrated a method for drying cellulose nanofiber (CNF) that retains the unique properties of the thickening agent. High transparency, high viscosity, and controllable viscosity were restored with simple stirring after the CNF was dehydrated from an organogel. Our powder had a much smaller volume than freeze-dried CNF, which will facilitate more efficient transport and storage. The method is expected to have a significant impact on food and cosmetics manufacturing.

What scientists learned about the rare antibodies targeting SARS-CoV-2’s Achilles’ heel could help fine-tune our COVID-19 vaccine strategy for longer-lasting immunity.

An international team led by Professor Yan Xu from Osaka Metropolitan University has developed a groundbreaking nanofluidic device, named NANa, capable of stochastically capturing and digitally detecting individual proteins at cellular concentrations. This tool, vital for precision medicine, is designed to handle tiny volumes equivalent to a single cell's contents and can identify single biomolecules even in high-concentration environments. The team plans to conduct further demonstrations using actual cell samples and explore the integration of this tool with AI and biological big data. This research could potentially revolutionize personalized disease prevention and treatment.

A combination of radiotherapy followed by immunotherapy is a promising strategy for the treatment of oral malignant melanomas in dogs.

Osaka Metropolitan University researchers succeeded, for the first time, in stabilizing the high-temperature phase of Li3PS4—a solid electrolyte material¬¬—thus attaining high ionic conductivity even at room temperature, using a method of rapid heating during its crystallization. This unprecedented achievement is expected to contribute to the development of materials for all-solid-state batteries with higher performance.

Researchers from Osaka University found that the binding of two proteins—Polydom and Tie1—is essential for lymphatic cell migration in the remodeling of lymphatic vessels, which transport molecules around the body. A better understanding of the development and remodeling of the lymphatic system will lead to better therapeutic options for diseases such as lymphedema, which is common in cancer patients and currently has no cure.

Adaption and mitigation efforts might be improved with inclusivity and transparency

A joint research group led by Osaka Metropolitan University has clarified how pathogenic genes in some Providencia spp., which have gained attention as causative agents of food poisoning as well as enterohemorrhagic Escherichia coli. O157 and Salmonella, are transferred within bacterial cells. Their findings are expected to provide new insights into the identification of infection routes of Providencia spp. and the establishment of preventive methods for food poisoning.

An international research group has engineered a new energy-generating device by combining piezoelectric composites with carbon fiber-reinforced polymer (CFRP), a commonly used material that is both light and strong. The new device transforms vibrations from the surrounding environment into electricity, providing an efficient and reliable means for self-powered sensors.

A physicist from the University of the Philippines – Diliman College of Science National Institute of Physics (UPD-CS NIP) led a team of researchers in pioneering a way to make a special kind of “dark” matter that can’t be observed using standard laboratory methods.

Tam Pà Ling, a cave in northern Laos, reveals new secrets about our earliest human journeys from Africa through to Australia.

Metamagnetic shape memory alloys (MMSMA) have negated some of the common problems associated with shape memory alloys thanks to their ability to undergo phase transformation when exposed to an external magnetic field. Yet they still lose a large amount of energy when phase transforming. Now, a research group from Tohoku University has made a significant breakthrough, developing a palladium-based MMSMA that exhibits low energy loss.

Osaka Metropolitan University scientists synthesized a novel molecule by combining dynamic covalent reactions based on organic radicals and coordination reactions. They found that the two types of reactions do not inhibit each other. Their results suggest the possibility of synthesizing materials by combining different types of reactions, which is expected to lead to the construction of structures that have never existed before.

Researchers at Kanazawa University report in ACS Nano how ultrathin layers of tin disulfide can be used to accelerate the chemical reduction of carbon dioxide — a finding that is highly relevant for our quest towards a carbon-neutral society.

Water from the Pacific Ocean flows into the Indian Ocean via the Indonesia Archipelago thanks to a vast network of currents that act as a conveyor belt, transporting warmth and nutrients. Currents can sometimes form circular motions and these are known as eddies. An international group of researchers has modeled the impacts of eddies on the currents that carry water from the Pacific Ocean to the Indian Ocean.

With the need for hardware to process large amounts of digital information ever growing, researchers are working hard to improve magnetoresistive devices. The magnetoresistance ratio indicates the efficiency of these devices, the higher the better. Most magnetoresistive devices comprise magnesium oxide and iron-based magnetic alloys. But a group of researchers from Tohoku University has unveiled a new material that also exhibits enormous magnetoresistance.

Researchers from Institute of Industrial Science, The University of Tokyo develop a nanosheet oxide semiconductor for electronic devices

A team led by researchers from Osaka University elucidated a molecular mechanism that is crucial for separating genetic material into daughter cells during cell division. A protein called CENP-C is part of a complex called the kinetochore, which supports the movement of chromosomes. Two portions of CENP-C, the CCAN-binding domain and Cupin domain, are needed for CENP-C to function. The Cupin domain repeats itself through oligomerization, which is essential for proper CENP-C function.

Ultrafast fluorescent imaging technology brings the molecular dynamics of living cells into clear view.

Researchers from Osaka University developed an in vivo CRISPR screen to analyze factors affecting Toxoplasma gondii fitness in healthy and immunodeficient mice. Mice were infected with Toxoplasma containing CRISPR libraries that targeted specific genes; genetic sequencing was then performed to identify which genes are important to fitness. The genetic screen clarified the contributions of host genetics and parasite genetics and can contribute to the development of strategies for toxoplasmosis treatment and prevention.

App leads to better birth preparation for pregnant women

Researchers at Tohoku University and Tsinghua University have introduced a next-generation model membrane electrode that promises to revolutionize fundamental electrochemical research.

Fragments of spherical ‘Buckyball’ molecules have stable electron-accepting ability with great practical potential.

Osaka Metropolitan University scientists investigated numerically the interaction between a quantized vortex and a normal-fluid. Based on the experimental results, researchers decided the most consistent of several theoretical models. They found that a model that accounts for changes in the normal-fluid and incorporates more theoretically accurate mutual friction is the most compatible with the experimental results.