Peer Reviewed

A tiny platform empowers scientists to examine how gut and liver cells interact in health and disease.

Researchers from the Institute of Industrial Science, The University of Tokyo, find that a deep-learning model that simultaneously learns to classify satellite data as rain/no-rain while determining rain intensity outperforms other models.

Osaka Metropolitan University scientists analyzed each element of the neutrino mass matrix belonging to leptons and showed theoretically that the intergenerational mixing of lepton flavors is large. Furthermore, by using the mathematics of random matrix theory, the research team was able to prove, as much as is possible at this stage, why the calculation of the squared difference of the neutrino masses are in close agreement with the experimental results in the case of the seesaw model with the random Dirac and Majorana matrices. The results of this research are expected to contribute to the further development of particle theory research, which largely remains a mystery.

Ferroptosis is a recently discovered type of cell death associated with certain neurodegenerative, cardiovascular and kidney diseases. Whilst scientists have understood that accumulated iron and degenerated lipids trigger ferroptosis, the actual mechanisms at play have remained a mystery. A team of researchers from Tohoku University has identified where in the cells these accumulations take place, and what gets targeted as ferroptosis occurs.

Researchers from Osaka University found that the COMMD3/8 complex is implicated in the progression of the autoimmune response in a mouse model of rheumatoid arthritis. They identified celastrol, the active compound of a medicinal herb, as an inhibitor of the COMMD3/8 complex. Celastrol blocked the progression of rheumatoid arthritis. Thus, celastrol is a potential lead for developing treatments against rheumatoid arthritis.

Marine predators have expanded their ranges into the Arctic waters over the last twenty years, driven by climate change and associated increases in productivity.

Asexual, or vegetative, reproduction in plants is controlled by environmental conditions, but the molecular signaling pathways that control this process are poorly understood. Recent research suggests that the KAI2-ligand (KL) hormone is responsible for initiating and terminating the production of gemmae, or genetically identical plantlets, on liverwort plants based on the presence or absence of specific environmental factors.

- The effect of the cycle of G proteins in real time on the two-step structural change of cell membrane receptors has been investigated - This study is expected to be applied to pathologies related to G protein-coupled receptors and on research for their treatments

- Research teams led by Professor Hongsoo Choi and Professor Yongseok Oh from DGIST joined the research team led by Dr. Jongcheol Rah from Korea Brain Research Institute to develop the technology for delivering a microrobot to a target point of a hippocampus in an in-vitro environment, connecting neural networks, and measuring neural signals - The research findings are expected to contribute to neural network research and the verification and analysis of cell therapy products

- DGIST Professor Minseok Kim’s research team has developed an electronic medicine that can restore normal Schwann cell phenotypes in CMT disease models - It presents the potential of electric stimulation-based treatment for chronic peripheral nerve disorders

- The world’s first technology for synthesizing high-quality and low-cost copper-graphene nanowire using intense scintillation - Implementation of high-performance transparent-flexible electronic device based on copper-graphene nanowire and publication in the international journal Nano Energy, which is renowned in the field of energy

Researchers from Osaka Metropolitan University Graduate School of Medicine conducted an interoperative comparison of lateral disc meniscus injuries of young patients (aged 15 or less), that were treated with plastic sutures or subtotal resection, to see if there was a difference in postoperative cartilage degeneration. The research group observed that sub-total meniscectomies were more likely to show cartilage degeneration, being worst in lateral disc meniscus injuries. In addition, they found that even with higher levels of meniscus damage, preserving the meniscus with sutures was more effective in protecting the cartilage in young patients.

Osaka Metropolitan University scientists have developed a process using artificial photosynthesis to successfully convert more than 60% of waste acetone into 3-hydroxybutyrate, a material used to manufacture biodegradable plastic. The results were obtained using low-concentration CO2, equivalent to exhaust gas, and powered by light equivalent to sunlight for 24 hours. The researchers expect that this innovative way of producing biodegradable plastic could not only reduce CO2 emissions but also provide a way of reusing laboratory and industrial waste acetone.

Researchers at Kanazawa University report in JACS Au how they have developed operando scanning ion conductance microscopy to allow simultaneous measurements of changes in the anode surface topography of a lithium ion battery during use, as well as the varying ion concentration with depth. Combining both types of information should help researchers evaluate the correlation between the two to design better batteries.

A research group at Osaka Metropolitan University has succeeded in simply creating an artificial metalloenzyme with the common metal-binding motif 2-his-1-carboxylate, which is found in natural non-heme metalloenzymes. They created a library of 12 different proteins and screened the library and found that the H52A/H58E variant had the best stereoselectivity. It is expected that this research can be expanded to produce a variety of biocatalysts that work under mild conditions.

A group including Osaka Metropolitan University researchers discovered that the rhodopsin—a protein in the eye that detects light—of whale sharks has changed to efficiently detect blue light, which penetrates deep-sea water easily. The amino acid substitutions–one of which is counterintuitively associated with congenital stationary night blindness in humans—aid in detecting the low levels of light in the deep-sea. Although these changes make the whale shark rhodopsin less thermally stable the deep-sea temperature, allows their rhodopsin to keep working. This suggests that the unique adaptation evolved to function in the low-light low-temperature environment where whale sharks live.

Cancer-associated fibroblasts (CAFs) are key factors in the tumor microenvironment, which have been implicated in cancer cell progression. It has also been reported that vesicles called exosomes produced by these CAFs play an important role in cancer progression. An Osaka Metropolitan University research group investigated the effect of CAF-derived exosomes on the growth of malignant melanoma cells. They found that CAF-derived exosomes express CD9 and CD63 transmembrane proteins, and that the CD9-positive exosomes may inhibit the growth of malignant melanoma cells.

· Duke-NUS sleep scientists’ analyses show associations between early classes, less sleep, poor attendance and reduced grade point average. · Studies in secondary and junior college students have shown that later start times can have positive impacts on grades.

An Osaka Metropolitan University joint research group has discovered that near-infrared absorbing dyes, which had previously been considered to have closed-shell electronic structures, have an intermediate electronic structure, between closed- and open-shell structures. They also found that as the wavelength of near-infrared light that can be absorbed becomes longer the contribution of open-shell forms increases within the dye. These newly discovered characteristics are expected to be utilized to develop new near-infrared absorbing dyes that can absorb longer wavelength near-infrared light.

Researchers from Osaka University have found that repeated high-dose treatment, known as pulse therapy, with the steroid methylprednisolone reduces in-hospital deaths in COVID-19 patients who receive invasive mechanical ventilation, but not in patients who don’t receive invasive mechanical ventilation. These findings were only possible using appropriate statistical methods to remove bias from the data, which originally seemed to show that the opposite was true. These results can improve patient treatment and reduce COVID-19-related deaths worldwide.

Hailey-Hailey disease is a rare, inherited condition characterized by patches of blisters appearing mainly in the skin folds of the arm pits, groin and under the breasts. It is caused by a mutation in the gene that codes for a specific protein. Tohoku University scientists have uncovered some critical details of this protein’s structure, and the findings could build the foundation for developing treatment for Hailey-Hailey disease and other neurodegenerative conditions.

A research group from Osaka Metropolitan University investigated the relationship between tobacco use, including heated tobacco products, with the risk of SARS-CoV-2 infection and severe COVID-19. The researchers administered an online survey of living conditions in February 2022 to 30,130 participants aged 16-81 years, finding that heated tobacco product users had significantly higher rates of SARS-CoV-2 infection compared to non-tobacco users. Furthermore, the research group found that among all tobacco users, those who used both heated tobacco products and traditional cigarettes had the highest incidence of requiring hospitalization or oxygen due to COVID-19.

Researchers at The University of Tokyo develop a gate driver for circuit bipolar transistor electronic switches with a timing function robust to changes in current and temperature, which can be used in many industrial control applications

Researchers from Osaka University identified a subset of fibroblastic reticular cells (FRCs) that simultaneously express two proteins, Aldh1a2 and Tie2, making them unique to areas of the omentum called milky spots. Genetic depletion of these cells caused structural disruption of milky spots. The FRCs were critical to the abdominal immune system as they regulated CXCL12 levels, a molecule necessary for lymphocyte recruitment from blood circulation. These insights can help develop novel treatments for intra-abdominal infections.

A research team has highlighted recent achievements in antiferromagnetic spintronics in a review article, unearthing a new frontier in the field.

Researchers from SANKEN (The Institute of Scientific and Industrial Research), at Osaka University in collaboration with researchers from Imperial College London (UK) have improved the Faradaic efficiency of the nitrogen reduction reaction into ammonia by straightforward optimization of chemical process parameters. They found that trace water was the probable source of the high selectivity by facilitating incorporation of lithium oxide into the solid electrolyte interphase. These findings will also aid optimization of other analogous reactions, and thus help the chemicals industry optimize the sustainability of one of the most carbon-intensive reactions globally.

Samples from the asteroid Ryugu collected by the Hayabusa2 mission contain nitrogenous organic compounds, including the nucleobase uracil, which is a part of RNA.

Parasitic infections in salmonid fish can increase or decrease their vulnerability to angling, depending on their body condition.

Tyrosine kinase inhibitors (TKI) are employed to attack specific types of cancer cells. The downside to using TKs is that they can cause serious inflammation. A team of researchers has discovered the underlying mechanism that causes this inflammation.

Bioengineers formulated a mathematical model that clarified the importance of bat ear motions in direction detection, making way for lean, mean sonar navigation machines.