23 Dec 2021
By searching for the protein transglutaminase 1 (TGM1) among patients with various autoimmune skin diseases, researchers have successfully identified a separate disease that can be linked to autoimmunity against TGM1. This backward method demonstrates a new way of identifying autoantigens as markers for various diseases. By letting autoantigens point to the disease, diagnosis and treatment can be facilitated, according to the study now published in PNAS.
22 Dec 2021
We have succeeded in establishing a mouse model that develops gastric cancer closely resembling advanced human gastric cancer. Using this model, we have discovered gastric cancer stem cells, i.e. Lgr5+ gastric cancer cells, essential for the development, maintenance, and metastasis of cancer. Our study provides an experimental system that enables detailed analysis of highly malignant gastric cancer and is expected to lead to the development of a breakthrough treatment for advanced human gastric cancer.
27 Oct 2021
Giants in History: Maqsudul Alam (14 December 1954 – 20 December 2014) was a biologist from Bangladesh who is renowned for his research on genome sequencing.
13 Sep 2021
iCeMS scientists and colleagues have designed a molecular code that powers up cancer-fighting immune cells.
11 Sep 2021
Giants in History: Chinese agronomist Yuan Longping (7 September 1930 – 22 May 2021) developed the first varieties of the high-yield, hybrid rice that brought food security to multiple countries including China, which had been ravaged by food shortages as recently as the mid-20th century.
10 Sep 2021
Researchers have identified a potential reason why lower numbers of COVID cases have appeared amongst smokers compared to non-smokers, even as other reports suggest smoking increases severity of the disease.
08 Sep 2021
A research team led by Hiroshima University Professor Satoshi Okada has determined that enhanced bone resorption activity due to a faulty immune response may underpin multifocal osteomyelitis — painful, chronic bone infections — in children with MSMD, a rare genetic condition resulting from a range of immune system mutations.
26 Aug 2021
A multi-functional, small molecule can tag mutant genetic sequences inside mitochondria for removal.
17 Aug 2021
Cells translate their genetic material at rapid rates with exquisite precision to reproduce, repair damage or even combat disease. But the process can deregulate and give rise to disease. Byproducts of errant processes can build up like gunk in the gears, especially around neurons, breaking down the repair mechanisms and causing further damage and even neurodegenerative disorders such as Alzheimer’s disease.
11 Aug 2021
Researchers discover a link between an increase in protein Ba of the complement immune system and the eventual development of thrombotic microangiopathy in patients who have received an allogeneic hematopoietic stem cell transplantation.
14 Jul 2021
Researchers have found a way to enhance radiation therapy using novel iodine nanoparticles.
09 Jun 2021
Publication bias, or the tendency of researchers and journals to not publish uninteresting findings, plagues much of the natural sciences and especially biomedical research. Hiroshima University researchers have developed a meta-analytic technique exploiting publicly available transcriptome databases that avoids the problem—and in so doing, discovered four genes previously unknown to be associated with responding to low-oxygen stress.
31 May 2021
High-resolution genome structural analyses combined with large-scale simulations show the arrangements of the genome’s spool-like structures affecting gene expression.
13 May 2021
A simple tool allows researchers to track how different subpopulations of the Plasmodium knowlesi parasite are changing over time.
13 Apr 2021
The O. swinhoana frog species is the first vertebrate known to retain descendant genes that now determine sex in mammals, birds, and fishes inherited from a common ancestor.
07 Apr 2021
New national body established to further research insights, improve patient outcomes and create new economic opportunities for the biomedical technology industry.
26 Mar 2021
An ‘eat-me’ signal displayed on cell surfaces requires activation of a lipid-scrambling protein by a nuclear protein fragment.
24 Feb 2021
Many genetic variants have been found to have a linkage with genetic diseases, but the understanding of their functional roles in causing diseases are still limited. An international research team, including a biomedical scientist from City University of Hong Kong (CityU), has developed a high-throughput biological assay technique which enabled them to conduct a systematic analysis on the impact of nearly 100,000 genetic variants on the binding of transcription factors to DNA. Their findings provided valuable data for finding key biomarkers of type 2 diabetes for diagnostics and treatments. And they believe that the new technique can be applied to studies of variants associated with other genetic diseases.
04 Feb 2021
Cells replicate their genetic material and divide into two identical clones to perpetuate life. Some cells pause in the process with a single, undivided nucleus. When the cell resumes division after such a pause, the nucleus can become caught in the fissure, splitting violently, and killing both cells. But that is not always the case. Researchers from Hiroshima University in Japan are starting to understand how active nuclear displacement rescues cell death.
28 Dec 2020
Investigations of a cellular protein have uncovered a possible link with schizophrenia.
21 Dec 2020
Researchers baffled by an infant’s rare encephalitis case unusual in children found unheard-of mutations and a new way to examine the “immunity gene.”
20 Nov 2020
A research team, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has presented the whole-genome sequence and analyses of the endangered whale shark (Rhincodon typus), the largest extant fish on Earth.
20 Nov 2020
A research team, affiliated with the Korea Genomics Center (KOGIC) at UNIST has released data from the initial phase of the Korean Genome Project (Korea1K), including information describing 1,094 whole genomes, along with 79 quantitative clinical traits.
19 Nov 2020
A repetitive DNA sequence that causes health risks when it malfunctions can now be watched inside living cells using a synthetic tool
04 Nov 2020
Innovative research by scientists at Duke-NUS Medical School has shed light on the mysterious role of long non-coding RNAs in the development of pancreatic cancer and suggests potential new targets for precision cancer therapies.
06 Oct 2020
Researchers at Kanazawa University report in Nature Communications the mechanism making some lung-cancer patients resistant to the drug osimertinib. In addition, they suggest a combined drug treatment resolving osimertinib resistance in the case of cancer cells expressing low amounts of AXL, a protein belonging to the class of receptor tyrosine kinases.
03 Oct 2020
A new apparatus improves how we study the effects of aiming high-field terahertz radiation at cells, with implications for regenerative medicine.
03 Jun 2020
A highly accurate machine learning tool could help doctors tailor individualized treatments for people with glioma brain tumours.
18 May 2020
Research at Kanazawa University, Theragen Etex Bio Institute and Seoul National University as reported in Nature Communications points towards pathways for the metastasis and malignant transitions that result from changes in the protein p53. The results suggest that the cooperative development of mutations in the proteins helps tumours spread and metastasis.
12 May 2020
In a recent study published in Molecular Cell, researchers at Kanazawa University report the role of cellular structures called PML bodies in regulating gene function
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