Science

Focusing on the imperative of integrating science, policy and clinical practice to advance global One Health movement especially in the aftermath of COVID-19, the Congress will feature sharing by leading global scientists and policymakers on ways to address complex global health challenges.

Osaka Metropolitan University scientists have discovered that, in the crystalline solid Ba1-xSrxAl2O4, a highly disordered atomic arrangement is formed in the AlO4 network at chemical compositions near the structural quantum critical point, resulting in characteristics of both crystalline and amorphous materials. This hybrid state, which the research team was the first to discover, can be created simply by mixing raw materials uniformly and heating them. These findings are expected to help with the development of hybrid materials for use in harsh environments, such as outer space, by applying the technique to a variety of materials.

Giants in History: Tsuneko (1933) and Reiji Okazaki ( 1930 – 1975)were a Japanese couple who discovered Okazaki fragments – short sequences of DNA that are synthesized during DNA replication and linked together to form a continuous strand.

Researchers from Osaka University have demonstrated a proof-of-concept for a novel use of artificial intelligence for enzyme engineering that does not require an enzyme’s crystal structure. By analyzing the amino acid sequences of malic enzymes from various living organisms, the researchers identified the amino acids that are pertinent to using different redox cofactors. The results of this work will facilitate retooling enzymes in research laboratories and the biotech industry.

6th NanoLSI Symposium: International symposium on Nanoprobe Technology for Understanding Molecular Systems in Kanazawa, Japan

While both protect from severe disease, inactivated SARS-CoV-2 and spike mRNA vaccines trigger different T-cell responses.

Call To Action urges G20 member countries and partners to mobilize adequate resources to close the TB funding gap and save lives.

A research group at Osaka Metropolitan University has developed a drug delivery system that activates a strong cellular immune response to attack cancer cells, using one-tenth of the amount of antigen needed in the group’s previous work. By incorporating positively charged cationic lipids into liposomes and adding negatively charged pH-responsive polysaccharides to the surface, the research group increased the uptake efficiency of liposomes encapsulating cancer antigens by dendritic cells by approximately five times, which increased cytokine production by about 100 times. This increased M1-type macrophages, which activate cancer immunity, and decreased M2-type macrophages, which promote cancer growth.

Osaka Metropolitan University scientists conducted a 7-year study on seedling recruitment and mortality in a national park in Chiang Mai, in northern Thailand. During the study period, an extremely strong El Niño event occurred, leading to a stronger and longer drought than normal. Seasonally dry tropical forests (SDTFs), which experience an annual dry season, are considered drought-tolerant. Nevertheless, the study found that seedling mortality increased in SDTFs when severe and prolonged drought occurred. The mortality rate was greater in evergreen forests at higher elevations that usually experience less severe drought than in deciduous forests at lower elevations where severe drought is more common. The study results advance the understanding of the effects of El Niño on seedling dynamics in SDTFs.

Giants in History: Shinichiro Tomonaga (31 March 1906 – 8 July 1979), together with Richard Feynman and Julian Schwinger, was awarded the Nobel Prize in Physics in 1965, for their contributions to advance the field of quantum electrodynamics.

Thirty-four scholars of The Education University of Hong Kong (EdUHK) were named among the top 2% most-cited scientists in the world, in an annual list released by Stanford University.

Researchers from The Institute of Scientific and Industrial Research (SANKEN) at Osaka University and collaborating partners prepared hierarchical hydrogels and moldings that consisted of anisotropic, ecofriendly cellulose nanofibers. By simply tailoring the applied voltage during fabrication, complex architectures—such as microneedles and multilayer hydrogels—were easy to prepare. The results of this work will reduce the need for petroleum-based plastics, and in so doing minimize a long-standing source of environmentally persistent waste.

Small neighboring galaxy filled with dark matter detected with gamma rays, How a virus induces heart inflammation, Shedding light on the happy hormone, Microfossils may hold key evolution clues. Read all in the October's Editor's Choice plus Upcoming event KNOWLEDGE MARKETPLACE – Bangkok 2022: Exchanging of ideas for a Democratic Myanmar.

Making complex polymers with precisely controlled structures becomes much simpler thanks to a new ‘one-pot-and-one-step’ synthesis procedure.

Investigations in Japan have uncovered some molecular mechanisms behind mitochondrial dysfunction in chronic heart failure.

Osaka University researchers showed that the predictions of Einstein’s theory of special relativity in electromagnetism could be detected in the contraction of the electric field created by ultrafast electrons. By achieving femtosecond resolution, they were able to visualize the contracted electric field for the first time. This work can be applicable to particle accelerators and high-energy physics.

An Osaka Metropolitan University researcher has provided a review article regarding INSL3, a circulating hormone secreted from the gonads, in domestic animals, in comparison to rodents and humans. In this review article, the author describes his research group’s work that (1) developed immunoassays, for the first time, that can measure circulating INSL3 in multiple domestic mammals, including cattle, goats, sheep, pigs, horses, and dogs, (2) provided evidence in studies with bulls and bucks that INSL3 offers more reliable and stable values by a single blood collection than testosterone, a conventional and well-known testicular hormone, and (3) suggested that blood INSL3 concentrations would be a good biomarker for testicular and reproductive functions in normal and abnormal male domestic animals. These findings suggest that the INSL3 assay might simplify the evaluation of reproductive functions in various male domestic animals. In particular, the assay method may facilitate earlier selection of valuable male animals such as beef sire bulls (Image) with higher reproductive performance, contributing to reductions in the labor and costs required for sire production.

Giants in History: Maharani Chakravorty (1937 – 2015) was one of India’s earliest molecular biologists whose research paved the way for advances in the treatment of bacterial and viral infections.

New insights into the role of a protein in the nerve cells of flies could help unravel the role of a related human protein in common cancers.

Scientists have uncovered new details of how ice forming below the ocean surface in Antarctica provides cold dense water that sinks to the seabed in an important aspect of global water circulation.

Pyroxenes are a major group of rock-forming minerals. Osaka Metropolitan University scientists investigated the iron ion status of a calcium-rich pyroxene, using Mössbauer spectroscopy on thin sections of single crystals. The study revealed that in pyroxene crystals consisting of roughly 50% calcium, the tensor that determines the ratios of iron ions at the Mössbauer spectral peaks in the M1 sites—one of two types of cation positions in the pyroxene crystal structure—is independent of the iron content but dependent on the calcium content. The research findings have clarified one of the physical properties of pyroxenes, facilitating detailed future analysis of iron using Mössbauer spectroscopy on mineral flakes.

A long-term experiment aboard the International Space Station has tested the effect of space radiation on mouse embryonic stem cells. Their findings will contribute to helping scientists better assess the safety and risks related to space radiation for future human space flights. The findings are published in the journal Heliyon.

Chemists in Japan, Canada and Europe have uncovered flaws in the surface structure of cellulose nanocrystals—an important step toward deconstructing cellulose to produce renewable nano-materials relevant to biochemical products, energy solutions, and biofuels.

Researchers from Osaka University have found that the Vibrio cholerae colonization factor TcpF forms a flower-shaped trimer to specifically bind to the minor pilus protein TcpB resulting in secretion by the type 4 pilus secretion system into the extracellular space. This finding could help lead to the development of a novel anti-adhesive drug that selectively interrupts the TcpF-TcpB interaction, which may replace antibiotics in the treatment of cholera.

Researchers from Osaka University have developed a computational analysis tool called CAPITAL for comparative analysis of single-cell RNA sequencing data with complicated branching trajectories. As cells undergo a dynamic process, they can be placed on a “pseudotime trajectory” to analyze the gene expression changes throughout the process. While previously only straightforward linear trajectories could be compared, CAPITAL is proven to be able to accurately compare branching trajectories, significantly advancing the field of high-throughput single-cell sequencing.

Osaka Metropolitan University scientists have created a novel thermoresponsive polymer by adding divalent cations to polymers and water solvents. They also succeeded in controlling thermoresponsive properties by changing the type and mixing ratio of ionic species. This new polymer type is expected to be applied as an analytical reagent for ion-sensing devices and as a material for drug delivery systems.

Puzzling image from the James Webb Space Telescope explained in two new studies

Osaka University researchers developed a power generation system based on osmotic flow of ions through a membrane riddled with tiny nanopores. By optimizing the size and distribution of the pores, the team demonstrated a way to obtain clean energy from the oceans.

Researchers at The University of Tokyo simulated fractures in amorphous materials due to both cyclic fatigue and constant stress using course-grained dynamics, and demonstrated various failure modes, which can help improve reliability of materials

The SARS-CoV-2 Omicron variant escapes the immune response better than its coronavirus ancestors, but has also facilitated our transition to a society that can live with COVID-19.