Science

In a study recently published in the journal ACS Nano, published by American Chemical Society, researchers from Kanazawa University, Kanazawa, Japan, collaborating with University of Washington, Seattle, USA, used frequency modulated atomic force microscopy to reveal the molecular architecture of a genetically designed peptide and its self-organization that forms single-molecule thick crystals on atomically flat graphite surfaces, that offer a potential platform for hybrid technologies such as bioelectronics, biosensors, and protein arrays.

Researchers at Kanazawa University report in ACS Nano how high-speed atomic force microscopy can be used to study the biomolecular mechanisms underlying gene editing.

Osaka Metropolitan University scientists succeeded in directly observing how LECs—which are attracting attention as one of the post-organic LEDs—change their electronic state over time during field emission by measuring their optical absorption via lamp light irradiation for the first time. This research method can be applied to all light-emitting devices, including not only LECs but also organic LEDs. This method is expected to reveal detailed electroluminescence processes and lead to the early detection of factors that reduce the efficiency of electroluminescence.

Researchers from Osaka University identified the role of a protein known as testis-specific kinase substrate (TSKS) in the process of spermiation, the release of mature sperm. Analysis of a gene-modified mouse model in which TSKS is disrupted revealed that TSKS is necessary for sperm to eliminate cytoplasm and become streamlined. These findings may lead to the development of diagnostic tests and male contraceptives.

Osaka Metropolitan University scientists successfully quantified the total reactive polysulfide content of 22 different types of vegetables, including onions and garlic. They also revealed that reactive polysulfides are not only found in the leek genus (Allium), such as onions and garlic but also in the cruciferous family of vegetables (Brassicaceae), such as broccoli and cabbage.

The first-ever molecular catalyst specifically tailored for mechanochemical reaction conditions enables high-efficiency transformations at near room temperature.

Finding extra-terrestrial life would transform how we view our place in the Universe, but reporting on the search for it poses challenges for scientists and the media.

A science communication course at the Earth-Life Science Institute (ELSI) in Japan provides graduate students with practical skills to communicate research to a diverse audience.

One astronomer never thought of leaving Japan, but then he did and became a world best.

Asia Research News met five female researchers to learn about their research, what drew them to Kavli IPMU, and their experiences there. These women, from diverse backgrounds, excel in their fields and show what can be achieved when women are not held back.

Existing colour systems, such as RGB and CYMK, are all text-based and require a large range of values to represent different colours, making them difficult to compute and time-consuming to convert. Recently, researchers from City University of Hong Kong (CityU) made a breakthrough by inventing an innovative colour system, called “C235”, based on prime numbers, enabling efficient encoding and effective colour compression. It can unify existing colour systems and has the potential to be applied in various applications, like designing an energy-saving LCD system and colourizing DNA codons.

Researchers from Osaka University found that Ca2+ signaling simultaneously performed signal amplification and olfactory adaptation. The results demonstrated that this mysterious phenomenon was segregated inside the cilium. A novel system was used to observe changes in Ca2+ dynamics inside the thin structure of a cilium. Unveiling the mystery of Ca2+ signaling segregation further clarifies the mechanisms underlying the human sense of smell.

Osaka Metropolitan University researchers have used 100 seconds of laser irradiation to generate convection currents that selectively accelerate biochemical reactions—due to the photothermal effect—by concentrating biofunctional molecules at the cell surface. Using this method, useful molecules can be transported into cells at concentrations a hundred to a thousand times lower than with conventional methods. Furthermore, they also succeeded in selectively introducing small molecules into intracellular organelles usually impossible at low concentrations (hundreds of pmol/L) as well as inducing cell death in targeted cells by concentrating anticancer active peptides into them at concentrations so low that they would not be conventionally effective (several tens of nmol/L).

Two novel hypotheses address the “two-fold cost of sex”: one of the biggest enigmas in the evolution of sexual reproduction.

Researchers at Kanazawa University report in Nano Letters the discovery of a biomolecular dynamical process likely relevant to gene expression. The process, revealed by means of high-speed atomic force microscopy, involves DNA and its packaging molecules.

Osaka Metropolitan University scientists identified about 140,000 molecular clouds in the Milky Way Galaxy from large-scale data of carbon monoxide molecules, observed in detail by the Nobeyama 45-m radio telescope. Using artificial intelligence, the researchers estimated the distance of each of these molecular clouds to determine their size and mass, successfully mapping the distribution of the molecular clouds in the Galaxy in the most detailed manner to date.

A team of researchers from Universiti Teknologi Malaysia and Universiti Malaysia Pahang has successfully developed an electrospinning method for producing Nylon Nanofibres for use in carbon fibre composites to enhance the impact properties of carbon composites.

Scientists from Oil Crops Research Institute (OCRI) of Chinese Academy of Agricultural Sciences (CAAS), Anhui Agricultural University (Anhui, China), Newcastle University in Singapore, and Huizhou Comvikin Biotechnology Co., Ltd (Guangdong, China) have developed a green and efficient approach to synthesize highly liposoluble and antioxidant L-ascorbyl esters by immobilized lipases.

This year’s roster is the third cohort to be inducted into the Hall of Master Academic Clinicians, an honour conferred on exceptional clinician-educators at the SingHealth Duke-NUS Academic Medical Centre.

An effective, stable solid-state electrochemical transistor has been developed, heralding a new era in thermal management technology.

Researchers from Osaka Metropolitan University have developed principles and technologies of nanofluidic devices to freely manipulate nanomaterials, biomaterials, and molecules at the single-molecule level using fundamental technologies such as nanofluidic processing, functional integration, and fluidic control and measurement, which has pioneered the way to integrate various fields under nanofluidics.

Researchers at Kanazawa University report in Angewandte Chemie International Edition how the formation and deformation speed of interlocked molecular structures called rotaxanes can be tuned — a discovery that may lead to an enhanced functionality of rotaxanes as building blocks for molecular machines.

Osaka Metropolitan University scientists found that 2-oxo-imidazole-containing dipeptides (2-oxo-IDPs) exhibit very high antioxidant activity. Furthermore, they established a method to selectively and sensitively detect very small amounts of 2-oxo-IDPs and revealed for the first time that several types of 2-oxo-IDPs are contained in meat, including beef, pork, and chicken.

A new approach that ‘baits’ the caps or telomeres protecting the ends of chromosomes could provide information on how rapidly we are ageing and what we need to do to slow it down.

To clarify the mechanism of serial dependence in number perception, a research team from Osaka Metropolitan University conducted two tests, independently asking subjects to estimate the number of coins, or to estimate the value of those coins, shown on-screen for half a second. The results showed that serial dependence was confirmed in both tasks and that the most significant effect on serial dependence was not caused by the last stimuli, but the subjects last response. These results indicate that higher-order cognitive processing has a greater influence on the occurrence of serial dependence.

In hepatic steatosis, hepatocytes "die," resulting in liver damage. Severe steatosis increases hepatocellular deaths, thus aggravating liver damage. The mechanism is unclear. Using mice, we show that mild steatosis causes apoptosis whereas severe steatosis predominantly causes necroptosis leading to cell rupture. This induces strong inflammation and new cell death, producing further liver damage. We reveal the transcription factor ATF3 to be involved in this process. Our results are expected to contribute to therapeutic method development.

Hydrothermal vents have been identified as a previously undiscovered source of dissolved black carbon in the oceans, furthering the understanding of the role of oceans as a carbon sink.

Osaka Metropolitan University scientists have demonstrated that fish can recognize “it’s me” when they themselves in a picture for the first time in non-human animals. Further testing made it clear that the fish recognize their own face in the pictures like humans.

Hokkaido University researchers have developed a novel method to design and develop peptide antibiotics in large numbers, which will prove critical to controlling antibiotic resistance.

A research group at Osaka Metropolitan University has derived a new evaluation method for the measuring the size X-ray microbeams (diameter) through mathematical analysis. The group then verified the validity of the mathematically derived evaluation method by measuring the diameter of X-ray microbeams using metal wires of various diameters with an X-ray fluorescence analysis system for small areas and found that it was possible to calculate the beam diameter more accurately than the previous conventional evaluation method.