Peer Reviewed

Epstein-Barr virus rewires host epigenome to turn on latent genetic enhancers that activate proto-oncogenes, leading to tumorigenesis in stomach cancer

A research group has developed a new, lightweight and motor-less device that can be easily attached to an ankle support device - otherwise known as an ankle foot orthosis (AFO). The new device will aid stroke patients in their rehabilitation, improving their walking and preventing falls.

While scientists still don’t fully understand the diverse nature of RNA molecules, it is believed that the proteins binding to them, called RNA-binding proteins, are associated with many disease formation. A research led by biomedical scientists from City University of Hong Kong (CityU) has developed a novel detection method, called CARPID, to identify binding proteins of specific RNAs in the living cells. It is expected the innovation can be applied in various cell research, from identifying biomarkers of cancer diagnosis to detecting potential drug targets for treating viral diseases.

A simple, rapid assay­­ to evaluate neutralizing antibodies that target the SARS-CoV-2 spike protein receptor binding domain (RBD) is described in a paper published in Nature Biotechnology.

Environmental pollutants threaten the health of marine mammals. This study established a novel cell-based assay using the fibroblasts of a finless porpoise stranded along the coast of the Seto Inland Sea, Japan, to better understand the cytotoxicity and the impacts of environmental pollutants on the porpoise population. The results revealed that the concentrations of PCBs and DDTs which accumulated in the porpoise are likely to have an adverse effect at the cellular level.

A research led by the Department of Geography at Hong Kong Baptist University (HKBU) has revealed that the observed average moving speed (or translation speed) of tropical cyclones making landfall over the coast of China dropped by 11% between 1961 and 2017. These slow-moving tropical cyclones brought about 20% more local total rainfall on average when compared with fast-moving ones, resulting in greater flood risks in the region.

The past is often the window to our future, especially when it comes to natural disasters. Using data from the 2018 floods that struck southwestern Japan to calibrate a machine learning model, researchers from the International Research Institute of Disaster Science (IRIDeS) at Tohoku University and the Japan-Peru Center for Earthquake Engineering Research and Disaster Mitigation (CISMID, in Spanish), have successfully identified the flooding caused by Typhoon Hagibis.

A hemispherical vanadium oxide cluster has a cavity that can accommodate a bromine molecule. It was found that a bromine molecule trapped in the cavity was polarized and that an alkane molecule like pentane, butane and propane could be brominated with the bromine molecule in the cavity with a selectivity differing from ordinary bromination. The present findings are expected to be useful for polarization of small molecules and design of highly functional catalysts.

Scientists demonstrate that the information about host bacteria–bacteriophage (phage) associations derived from world’s first metagenome analysis is useful for the development of phage therapies against intestinal pathobionts.

Researchers at Kanazawa University report in Biomaterials a high-speed atomic-force microscopy study of protein filaments in the nuclear pore complex. The visualization in real-time of the filaments’ dynamics is an important step in our understanding of molecular transport mechanisms between a cell nucleus and its surrounding medium.

Proteins play roles by interacting with various other proteins. Therefore, interaction analysis is an indispensable technique for studying the function of proteins. In this research, we have developed a biotinylation enzyme, AirID, using an ancestral enzyme reconstruction algorithm. AirID is a highly active biotinylation enzyme with low toxicity. By using AirID, comprehensive biotinylation of proteins interacting with a target protein in cells was achieved when the target protein was expressed as a fusion protein with AirID.

A method that involves infecting liver cells with mosquito-bred parasites could improve the study of malaria in India.

Allogeneic stem cell transplantation can cause a loss of protective goblet cells from the colon’s inner lining, which can be fatal. But boosting those cells beforehand could improve the outcome.

Scientists at Hokkaido University and collaborators have identified how inflammatory changes in tumors caused by chemotherapy trigger blood vessel anomalies and thus drug-resistance, resulting in poor prognosis of cancer patients.

"Neuromorphic" refers to mimicking the behavior of brain neural cells. When one speaks of neuromorphic computers, they are talking about making computers think and process more like human brains-operating at high-speed with low energy consumption.

Researchers at Kanazawa University report in the Biophysical Journal that the process of cell removal from an epithelial layer follows from an inherent mechanical instability. Moreover, the forces generated by an extruding cell can drive the extrusion of other cells in a particular direction.

Scientists are looking for ways to make millions of molecule-sized robots swarm together so they can perform multiple tasks simultaneously.

COVID19 is teaching us several new lessons and also preaching us to learn from the past experiences.

Researchers at the University of Tsukuba and RIKEN in Japan spark a hibernation-like state in mice—a species that does not naturally hibernate

We move our eyes several times per second. These fast eye movements, called saccades, create large image shifts on the retina - making our visual system work hard to maintain a stable perceptual world. Remapping the retinal image compensates for this; however, errors in actual eye movements cause image shifts, even with remapping.

A new study reveals that asteroid impact sites in the ocean may possess a crucial link in explaining the formation of the essential molecules for life. The study discovered the emergence of amino acids that serve as the building blocks for proteins - demonstrating the role of meteorites in bringing life's molecules to Earth, and potentially Mars.

Podonychus gyobu sp. nov., a second species of the genus Podonychus Jäch & Kodada, 1997, hitherto known only to inhabit Indonesia, is reported to have been found in Kyushu, Japan. The endophallic structures and the larva of P. gyobu sp. nov. are described.

A transparent container made by Nagoya University researchers allows easy and quick grafting of very young plants, with benefits for agriculture and plant research.

Hokkaido University scientists have succeeded in synthesizing an α,α-difluoroglycine derivative, a type of α-amino acid, based on a reaction path predicted by quantum chemical calculations. This novel method, combining experimental chemistry and computational chemistry, could innovate the development of new chemical reactions.

A group of Japanese scientists has developed an ultrastable, selective catalyst for dehydrogenate propane – an essential process to produce the key petrochemical substance of propylene – without deactivation, even at temperatures of more than 600°C.

Researchers from University of Tsukuba and the University of Tokyo identify neurons responsible for memory consolidation during REM sleep

A highly accurate machine learning tool could help doctors tailor individualized treatments for people with glioma brain tumours.

The present study screened known and unknown organohalogen compounds present in mussel and sediment samples from Hiroshima Bay. The results provided scientific evidence that unknown mixed halogenated compounds are ubiquitous in the coastal environment and possess bioaccumulative potential as high as persistent organic pollutants.

With increasing unemployment, economists are devising and proposing economic measures that could help ensure a sustainable increase in consumer spending and circumvent a long-term economic recession. However, whether the proposed economic measures are going to provide a long-term solution to these problems remains a concern.

An international collaborative team from PROS Ehime University and CellFee Science, Japan; the Walter and Eliza Hall Institute, Australia; Pasteur Institute, France; and Foundation for Innovative New Diagnostics, Switzerland developed a new diagnostic blood test which detects recent exposure to ‘vivax’ malaria. The new test can also identify people who may harbor dormant liver-stage malaria parasites, which can cause illness. This new diagnostic approach has the potential to enhance malaria surveillance and accelerate elimination.