Biology

Research out of Osaka University investigated the effect of increased cell temperature on the contractility of skeletal muscle and cardiac muscle by heating the muscle proteins using advanced microscopical techniques. The findings indicated that skeletal muscle is more sensitive to increases in temperature than cardiac muscle, and that heating can rapidly activate the contractile proteins of skeletal muscle, thereby improving muscle performance.

A research team from Osaka Metropolitan University has found that polysulfides are abundant in broccoli sprouts. They found that the amount of polysulfides increased dramatically during growth, by an approximately 20-fold in seeds by the fifth day of germination. Furthermore, a comprehensive analysis of the polysulfides detected a number of polysulfide candidates whose structures have not yet been determined. The identification of these unknown polysulfides and detailed analysis of their pharmacological activities are expected to enable the development of new preventive and therapeutic strategies and medicines for cancer, neurodegenerative diseases, stroke, inflammation, and other diseases.

Risk-averse on/off-target assessment for CRISPR editing without reference genome

Evaluation of developmental toxicity in early chicken embryos exposed to tris(2-chloroisopropyl) phosphate

This study examined how the origin (wild or hatchery-reared), feeding area (Baltic Sea mainstem, Bosnian Sea, and Gulf of Finland), and organic halogen compound (OHC) concentrations of Baltic Sea Atlantic salmon (Salmo salar) affect the salmon liver proteome, transcriptome, and oxidative stress markers. Results suggest that the Baltic salmon liver proteome, together with the transcriptome, is influenced more by OHC concentrations and oxidative stress levels in the feeding area than by their origin.

Structural characteristics of environmental pollutants and computer simulations predict effects on the endocrine system of seals

A new amphipod species thrives at record temperatures in nearby hot spring pools of an ancient Inca city, defying norms for these typically cold-dwelling animals. Unraveling its key adaptations can give clues for the survival of other freshwater creatures in our warming world.

The shortlist for the Applied Microbiology International Awards 2023 has now been announced. The AMI Awards programme is designed to celebrate the brightest minds in our field and promote the research, group, projects, products and individuals who continue to help shape the future of applied microbiology.

New research reveals how disrupted energy production in the kidneys contributes to progressive kidney disease in diabetes.

Osaka Metropolitan University researchers have used the power of laser light to accelerate the reaction between cancer cell-derived extracellular vesicles—a kind of nanoparticle—and antibody-modified microparticles. The three-dimensional structure of the resulting aggregates was then analyzed using a confocal optical system. The results demonstrated the ability to measure, within 5 minutes, approximately 1,000 to 10,000 nanoscale EVs contained in a 500 nL sample.

Hunting for supermassive black holes, Coastal survival at risk, Calcium and dead cell clean-up, Two naps are better than one & Pineapple leaf prosthetics. Read all in the latest Editor's Choice.

The finalists in the Applied Microbiology International Product of the Year Award 2023 have been announced. The awards promote the research, groups, projects, products and individuals who are shaping the future of applied microbiology.

Acoels have been found to host a wide diversity of symbiotic, photosynthetic microalgae.

The authors discovered a shorter isoform of Rubicon called RUBCN100, which enhances autophagy in B cells.

The authors identified a structure in the circadian mRNA Period2 that affects the sleep-wake cycle. The results indicate how translation and post-transcriptional processes influence the body’s internal clock and its impact on sleep patterns.

Researchers led by Osaka University developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of enzyme that makes single-stranded “nicks” in the DNA. Repair of these nicks is more efficient and accurate than repair of double-strand breaks caused by the current CRISPR/Cas9 editing. This technique represents a novel approach for the treatment of genetic diseases caused by heterozygous mutations.

- Team led by DGIST Professor Seo Sang-won, in collaboration with IBS Molecular Activation Catalysis Research Team, significantly simplifies complex antibiotic synthesis processes - Synthesizing pharmaceutical raw materials with a 700 times higher market value from hydrocarbons using economical catalysts - Article published in Nature Catalysis, the top international journal in chemistry

This novel technology: - provides potential treatment in relation to restoring aging muscle cells obtained from older adults and remedying sarcopenia in aging animals through bioelectric medicine - presents a new paradigm for treating sarcopenia, for which no drugs are currently available to treat this condition - has been reported in the internationally renowned academic journal, Proceedings of the National Academy of Sciences (PNAS)

- Research team led by Professor Minsik Kim at DGIST discovered the mechanism of autism spectrum disorder caused by the use of valproate in pregnant women through multi-institution joint research - Published in the world-renowned journal “Experimental & Molecular Medicine”

- Initial research findings from the project led by the Korea Environmental Industry & Technology Institute, focused on “Advancing Island Wildlife Materials.” - Contributing to securing wildlife and constructing utility information big data.

- Team led by Professor Choi Hong-Soo at DGIST enhances the effects of magnetic hyperthermia and particle penetration into cancer cells through the chain disassembly mechanism of magnetic nanoparticles induced by magnetic fields and magnetic propulsion. - Expected to play a major role in targeted drug delivery for cancer treatment through research related to magnetic carriers. - The research findings have been published in ACS Nano, a top-tier journal in the field of materials science.

Scientists have found that extracellular calcium mediates the activation of a membrane protein that waves the flag signalling cell death

Researchers at Osaka Metropolitan University have developed a measurement technique that rapidly measures the number of viable bacteria in food products. They have succeeded in drastically reducing the inspection time from 2 days to about 1 hour. With this technology, it will be possible to confirm food safety before shipment from factories and prevent food poisoning.

AXL and EGFR inhibitors combined hold promise in fighting certain head, neck, and lung cancers

Researchers have unveiled an intriguing phenomenon of cellular reprogramming in mature adult organs, shedding light on a novel mechanism of adaptive growth. The study, which was conducted on fruit flies (Drosophila), provides further insights into dedifferentiation - where specialized cells that have specific functions transform into less specialized, undifferentiated cells like stem cells.

Capturing carbon dioxide, Shells go nuclear, Worms surf electric fields, Brain repair & Creating matter from light. Plus from our blog: Monitoring research for further impact. Read all in the latest Editor's Choice.

Study addresses gaps in understanding of swine influenza A virus evolution and highlights need for early warning of disease emergence

Researchers at Kanazawa University report in Cell Reports how alterations in the nuclear pores lead to the degradation of anti-tumor proteins.

In recent years, an emerging zoonotic pathogen called E. albertii, transmitted by wild animals such as raccoons, has garnered attention due to its remarkable similarities to several strains of Escherichia coli (E. coli), including O157, and its potential to cause severe illness, particularly in children. A research group at Osaka Metropolitan University has developed a novel culture medium that allows for the selective cultivation of E. albertii from raccoon fecal samples. This enabled the successful isolation of E. albertii even from samples with very low quantities of this bacterium. Their findings are expected to further elucidate the bacteriological characteristics of E. albertii and to contribute to the control of foodborne illnesses.

DishBrain reveals how human neurons work together to process information. Living model of brain could give insights into the mechanisms of how we understand and experience the world.