Biology

東京工業大学地球生命研究所（ELSI）は今年、転機を迎える。10年前の設立当初からのテーマであった「地球と生命の起源」から踏み出し、地球外生命の可能性まで研究対象を広げていく。次期所長の関根康人教授にこれからのELSIが目指すところを聞いた。

Microgravity worms help solve astronaut muscle problems, CO2 recycling and drug development, Remote control of robot hand, Enabling the study of diverse Hepatitis B. Read all in the March's Editor's Choice and even more in the Asia Research News 2022 magazine.

The Earth-Life Science Institute (ELSI) based at Tokyo Institute of Technology will reach a turning point this year. For the first time in its 10-year history, it will extend the scope of its initial research theme, "The Origins and Evolution of the Earth and Life", to include searching for evidence of extra-terrestrial life. ELSI’s new director, Yasuhito Sekine, told Asia Research News what they hope to achieve in the next phase and how.

A research group has revealed that amyloid-β (Aβ) detected in blood is secreted from peripheral tissues (pancreas, adipose tissue, skeletal muscle, liver, etc.) that are sensitive to glucose and insulin. Also, that Aβ secreted from peripheral tissues acts as a regulator on pancreatic β-cells to suppress insulin secretion. The results of this study indicate that blood Aβ levels fluctuate significantly with diet, and special care should be taken when using blood samples as a diagnostic marker for Alzheimer's disease, such as taking blood samples during fasting.

Unlike most traditional Japanese universities, the Earth-Life Science Institute (ELSI) at Tokyo Institute of Technology has created a ‘flat’ and diverse research environment. On its ten-year anniversary, Outgoing Director Kei Hirose shares what is special about the institute and the secret behind its successful management.

A study on puddle frogs suggests underestimated biodiversity in Southeast Asia.

A soft hydrogel could help scientists find treatments for drug-resistant cancer stem cells.

Scientists have developed a model that predicts six tropical fish species will expand into northern parts of Japan as sea temperatures rise.

Researchers discovered the gene expression regulation mechanisms that drive coral transition from a floating larvae to one that sits sedentary in reefs.

Giants in History: Roseli Ocampo-Friedmann (23 November 1937 – 4 September 2005) was a Filipino-American scientist whose research focused on cyanobacteria and microorganisms that inhabit extreme environments.

An analysis method for protein–protein interactions using proximity-dependent biotinylation for next-generation drugs

Tests using a mouse model of Alport syndrome suggests that turning off a cell signalling protein may significantly prolong life by preventing kidney scarring.

Researchers in Malaysia are using the chemistry of natural products for sustainable health and energy solutions.

Scientists from Hokkaido University and colleagues have identified a pathway that accelerates plant flowering in low-nitrogen soils — a finding that could help enhance agricultural production.

A research team led by the National Institute for Physiological Sciences and joined by Hokkaido University explored the role of pain neurons in the regulation of endotoxic death. They found that peptide named Reg3γ acts as a pain neuron-enriched brain-targeted hormone that protects the host from endotoxic death.

Scientists develop a method to genetically label neurons with a single gene of interest in mice by combining the anterograde transsynaptic spread of adeno-associated virus serotype 1 (AAV1) with intersectional gene expression. In two distinct circuits: the retina/primary visual cortex to the superior colliculus and the bilateral motor cortex to the dorsal striatum, injections of AAV1 expressing either Cre or Flpo recombinases and the Cre/Flpo double-dependent AAV into two upstream regions and the downstream region, respectively, were used to label postsynaptic neurons receiving inputs from the two upstream regions.

A team at Japan’s Earth-Life Science Institute (ELSI), at Tokyo Institute of Technology (Tokyo Tech) is conducting evidence-based outreach to demonstrate why science communication training is so important, with an aim of encouraging other higher education and research institutions to follow its lead.

The Earth-Life Science Institute (ELSI) in Tokyo launches a new integrated graduate course exploring the origin and evolution of life and planets.

Giants in History: Gopalasamudram Narayanan Ramachandran (8 October 1922 – 7 April 2001) is best known for developing the Ramachandran plot to understand the structure of short chains of amino acids, known as peptides.

An innovative sample preparation method for cellular proteomics and protein structural analysis

Our visual processing is facilitated by spaces near the hand in a process known as hand proximity attention. Using a visual phenomenon called the flash-lag effect, researchers showed that proprioceptive information of a hand contributed to hand proximity attention.

A Japanese research team created a new way to sort living cells suspended in fluid using an all-in-one operation in a lab-on-chip that required only 30 minutes for the entire separation process.

• Your chances of getting resuscitated by a bystander in Asia if your heart suddenly stops while in a public place depends on whether you’re a man or a woman. • Across nine Asian communities, in public locations, the bystander CPR rates were 31.2 per cent for females and 36.4 per cent for males. • For women, the chances of receiving bystander CPR when suffering a cardiac arrest in a public out-of-hospital setting is lower than for men; in homes or private places, the likelihood is reversed.

Diarrhea is common in calves and causes enormous financial losses to the livestock industry worldwide. Antibiotics are often used to treat this, but it causes harmful side effects. A research group addressed this problem by exploring an alternative method. Feces from healthy donors were analysed before being transplanted into calves suffering from diarrhea in a process called fecal microbiota transplantation.

New research finds the extent of arterial occlusive disease in the popliteal artery correlates with the prognosis of peripheral arterial disease in lower limbs. The study of 31 patients who underwent percutaneous angioplasty of femoropopliteal artery (FPA) proved for the first time that ulcerated plaque observed in the FPA during angioscopy is the source of the thromboembolic mechanism in the popliteal artery.

An international team of researchers respond to criticisms on previous work that demonstrated Mirror Self-Recognition (MSR) in the cleaner fish Labroides dimidiatus, by 1) successfully repeating the mark test with a larger sample size, 2) showing the MSR behaviour to be the visual result of the mark not a physical response to it, and 3) showing that MSR-trained fish do not show aggression to spatially varied mirror images of themselves. Additionally, they further demonstrate potential self-awareness in L. dimidiatus by showing that they do not demonstrate MSR behaviour when visually presented with the mark on other fish and solidify the importance of ecologically relevant marks presented in previous work by showing MSR behaviour of L. dimidiatus with brown marks, meant to resemble a main food source of the fish, as opposed to no such behaviour in fish with green or blue marks.

Giants in History: Barry Paw (29 August 1962 – 28 December 2017) was a biologist and oncologist born in Myanmar who discovered several novel genes and their functions in red blood cells.

This is a novel study that attempted to construct a pH-sensitive delivery system into T cells and their subsets using carboxy-terminal Phe- and CHex-modified dendrimers with different structures, i.e. PAMAM-CHex-Phe and PAMAM-Phe-CHex. The findings contribute to the development of nanoplatforms for direct delivery to T cells to control the functions of T cells, which play key roles in cancer immunotherapy. This is the first report on direct delivery into T cells using pH-sensitive DDS.

Simulations have led to the fabrication of a polymer-DNA gel that could be used in tissue regeneration and robotics.

Researchers at The University of Tokyo demonstrate the theoretically optimal search method for organisms that employ the “run-and-tumble” technique, and find that it conforms with observations of chemotaxis by E. coli, which may help automate drones