Biology

14-3-3η: A protein that helps fight RNA viruses but can also be manipulated by them. New research reveals its complex role in the immune response

A nonirritant, antibacterial solution to prevent oral inflammation may lie in citrus and coconut chemical compounds

Researchers at Kanazawa University report in eLife on deciphering the actin structure-dependent preferential cooperative binding of cofilin.

Researchers at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, used high-speed atomic force microscopy to observe dynamic changes in AMPA receptors, which are vital for brain communication. Their findings, published in ACS Nano, reveal how these receptors adapt during signal transmission and suggest potential targets for neurological therapies.

Professor Hsiao-Wei Yuan from the School of Forestry and Resource Conservation at National Taiwan University (NTU) has been leading a team since 2003 dedicated to the research and protection of the endangered Chinese Crested Tern, also known as the 'Mythical Bird,' with only fewer than 100 individuals remaining. Their efforts have drawn international attention to this species, leading to conservation efforts and showcasing Taiwan's efforts in biodiversity conservation and key research achievements. After 20 years of conservation efforts, the population of Chinese Crested Terns has increased to approximately 150 individuals.

A newly developed compound that reduces harmful inflammation in rats caused by overactive neutrophils shows great potential as a safer treatment for various inflammatory diseases in humans.

One of the smallest lifeforms may have the biggest impact on marine ecosystems. Researchers at Tohoku University modeled how climate change can affect phytoplankton – and our future.

Researchers from Osaka University find that the transcription factor Ikaros binds to Foxp3 to inhibit the expression of target genes, including Ifng, in regulatory T cells

Cell–cell adhesion-induced patterning in keratinocytes can be explained by just starvation and strong adhesion, Hokkaido University researchers find.

A newly discovered mechanism of fear memory formation in mouse brains may help reduce the negative impact of fear and provide new treatment methods for post-traumatic stress disorder (PTSD) in the future , according to a study published on August 5th in the open-access journal Cell Reports by Wen-Hsien Hou (侯文賢) from National Yang Ming Chiao Tung University, Taiwan, and colleagues.

Hidden hand that carves life, Plant-inspired water purification, 3D-printed meals, Fast-glowing molecule, See less to move better. Read all in the latest Editor's Choice.

Applying chaos theory to the movement of iconic arctic whales uncovered a 24-hour diving cycle and a long-range (~100 km) synchronization.

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, IMDEA Nanoscience (Madrid, Spain) and CNB-CSIC (Madrid, Spain) report in ACS Nano experiments that reveal a cycle of conformational stages that recombinant Influenza A genomes pass through during RNA synthesis.

Wild boars and red junglefowl gave rise to common pigs and chickens. These animals’ genes evolved to express themselves differently, leading to signatures of domestication — such as weaker bones and better viral resistance — in pigs and chickens, according to a research team based in Japan.

- DGIST-Sungkyunkwan University research team successfully develops a next-generation bioelectronic suture that can monitor inflammation around wounds in real time - Maintains the functionality of traditional surgical sutures while monitoring inflammation... Expected to contribute to advances in wound care and related medical fields

A research group led by Associate Professor Katsuya Sakai, Researcher Nichole Marcela Rojas-Chaverra, and Professor Kunio Matsumoto of the Cancer Research Institute and Nano-Life Science (WPI-NanoLSI) at Kanazawa University has developed a long-acting, subcutaneously injectable artificial hepatocyte growth factor (HGF) mimetic molecule using a fusion technology of cyclic peptides and protein engineering. They demonstrated in a mouse model that it improves liver fibrosis, lipid accumulation, and inflammation caused by non-alcoholic steatohepatitis (NASH). This research result provides an option for the development of NASH therapeutics as well as a technology for creating growth factor and cytokine mimetic molecules with improved pharmacokinetics.

Commercially important marine fish and invertebrate species will likely shift northwards under a warmer climate.

Applied Microbiology International has announced that it has recruited 11 new Global Ambassadors from around the world.

- DGIST Professor Seo Dae-ha’s team has developed a methodology that combines nanoparticles, high-resolution microscopy, and analytical algorithms to observe intracellular cargo transport strategies. - They observed the three-dimensional movement of endosomes during intracellular transport and discovered the real-time strategy of cells for efficient transport. - The research findings were published in Advanced Science.

- DGIST Prof. Lee Kwang and team propose new neural law of dopamine that differs from existing theory - Developed original technology that simultaneously monitors electrical and chemical brain signals, redefining the correlation between changes in dopamine signaling within physiological range and neural signal processing in the brain - Findings are published in Nature Neuroscience

Elucidation of the substrate recognition mechanism of ArcS, the second-step enzyme for archaeosine synthesis in tRNA

During embryonic development, cells proliferate rapidly and differentiate to form tissues and organs of multicellular organisms. Paradoxically, since the 19th century, scientists have discovered that these processes that foster the creation of life is often accompanied by large-scale cell death. Why? This is a century-old mystery. Dr. Sheng-hong Chen and his team from the Institute of Molecular Biology's Lab for Cell Dynamics discovered that large-scale cell death occurs through Reactive Oxygen Species (ROS)-mediated ferroptosis trigger waves, published online in Nature in July 2024.

Combination of venetoclax and azacitidine helps patients with AML who relapse after hematopoietic cell transplant

Evaluation of developmental toxicity of early chicken embryos exposed to chlorinated paraffins

The European Molecular Biology Organization (EMBO) announced its 2024 Members and Associate Members on July 9, 2024. James Liao, President of Academia Sinica in Taiwan, was elected as an "Associate Member." Liao was one of the 20 scientists outside Europe to receive this prestigious recognition this year.

A method to screen a wide variety of drug candidates without laborious purification steps could advance the fight against drug-resistant bacteria.

Researchers from Japan discover a new enzyme with promising antibacterial activity

- DGIST Professor Ko Jaewon and team identify a single family of synaptic membrane proteins that inhibit excitatory and synaptic properties - The findings may provide key clues to the development of therapeutics for related brain disorders targeting different synaptic protein complexes inhibited by MDGA proteins * MDGA: a synaptic adhesion protein that plays an essential role in how nerve cells connect with each other to transmit neural signals.

Study suggests mycoviral infections affect the ecology of host oomycete

Study shows fish may use punishment to promote help from their offspring