Chemistry Organic chemistry
19 May 2023
Researchers at the Institute of Industrial Science, The University of Tokyo, use artificial intelligence to help interpret data generated by material science spectroscopy experiments, which can aid in the development of new drugs and organic conductors.
16 May 2023
Researchers at Osaka University discovered a new class of photo-responsive crystal compounds, heteroaromatic 1,2-diketones. Certain light irradiation causes the crystals in these materials to melt, dramatically changing the materials’ properties. One member of this class, SO, shows luminescent changes while melting, which enabled the research team to visualize the crystal-melting process at the molecular level. These findings provide fundamental insights into the mechanisms behind crystal melting and will enable future designs of light-responsive materials.
10 Mar 2023
The first-ever molecular catalyst specifically tailored for mechanochemical reaction conditions enables high-efficiency transformations at near room temperature.
21 Feb 2023
Researchers at Kanazawa University report in Angewandte Chemie International Edition how the formation and deformation speed of interlocked molecular structures called rotaxanes can be tuned — a discovery that may lead to an enhanced functionality of rotaxanes as building blocks for molecular machines.
16 Feb 2023
Amide bonds are important functional groups in medicinal chemistry and account for roughly 16% of all reactions performed in drug-discovery research. Some amide bond reactions using pharmaceutically important nitrogen-containing heterocyclic compounds, such as indole, carbazole and pyrrole, rather than amines are not efficient using conventional production methods. In a recent study, a team of leading chemists developed a novel one-pot reaction to efficiently form amide bonds using low-reactivity, nitrogen-containing heterocyclic compounds and carboxylic acid without special equipment or heat.
07 Feb 2023
Two catalysts working in tandem enable inexpensive formate salts to perform difficult dearomative reactions, giving products potentially useful for drug development.
03 Feb 2023
Researchers used a chemical synthesis robot and computationally cost effective A.I. model to successfully predict and validate highly selective catalysts.
02 Feb 2023
Researchers from Osaka University have used single carbon atom doping to form four chemical bonds in one step. Gamma-lactams (cyclic molecules that are common in antibiotics) were easily synthetically accessible from alpha, beta-unsaturated amides (an important molecule in cancer progression). The team chemically modified an anti-seizure medication in 96% yield, highlighting the work's utility to otherwise synthetically complex aspects of pharmaceutical development. The results of this work could become foundational to drug discovery and development.
01 Dec 2022
Automated reaction path search method predicts accurate stereochemistry of pericyclic reactions using only target molecule structure.
09 Nov 2022
A flipping action in a porous material facilitates the passage of normal water to separate it out from heavy water.
25 Oct 2022
Making complex polymers with precisely controlled structures becomes much simpler thanks to a new ‘one-pot-and-one-step’ synthesis procedure.
26 Sep 2022
Hokkaido University researchers find a new way of producing the industrially important propylene that is more energy efficient than existing approaches—and in the process turns carbon dioxide into another usable resource. Their pioneering catalyst design thus contributes to the carbon neutralization of the petrochemical industry.
28 Jun 2022
Researchers from the Institute of Industrial Science, The University of Tokyo, find that organic vapors can induce dissolution of molecular salts (i.e., organic deliquescence), similar to water vapor-induced deliquescence
18 Jun 2022
The molecule is unusual and has ‘great potential’ in catalysis, conduction and other applications.
23 May 2022
Tetraphenylammonium, with all four hydrogens of ammonium (NH4+) replaced with benzene rings, has neither been discovered in nature nor chemically synthesized, calling into question whether it could exist. Here, we succeeded in synthesizing tetraphenylammonium for the first time, demonstrating its stable existence. The synthetic strategy used in this study, radical coupling, may be applicable to the synthesis of various related ammoniums with high structural novelty.
19 May 2022
Scientists have synthesized the first belt-shaped molecular nanocarbon with a twisted Möbius band topology—a Möbius carbon nanobelt—that paves the way for the development of nanocarbon materials with complex topological structures.
19 May 2022
Structural color printing creates new pathways for medical diagnostics and miniaturized sensors
21 Apr 2022
A porous material, which opens to receive highly flammable acetylene and closes to release it, sidesteps the flaws of the existing storage method.
14 Mar 2022
Researchers aim to streamline the time- and resource-intensive process of screening ligands during catalyst design by using virtual ligands.
22 Feb 2022
Using electricity, a new method offers the possibility of recycling CO2 while also performing a notoriously difficult reaction, producing compounds potentially useful for drug development.
27 Jan 2022
Researchers have developed an innovative catalyst for the synthesis of propylene, which has potential benefits for the chemical industry and carbon recycling.
18 Jan 2022
A new method for creating a highly useful chemical subunit eliminates the need for precious metals, potentially leading to the sustainable production of pharmaceuticals and electronics.
18 Nov 2021
A new method for creating one of chemistry’s most widely used class of compounds could revolutionize industrial processes, making them cheaper, simpler and more environmentally friendly.
15 Nov 2021
Giants in History: Indian organic chemist Asima Chatterjee (1917 to 2006) studied the medicinal properties of plant products, especially compounds known as vinca alkaloids.
15 Oct 2021
Researchers from The University of Tokyo Institute of Industrial Science use a machine learning approach to successfully predict material properties that have never before been determined
05 Oct 2021
Researchers in Japan have found an energy-efficient way to convert the chief greenhouse gas carbon dioxide (CO2) into useful chemicals. Using the method, CO2 is transformed into structures called metal-organic frameworks (MOFs), suggesting a new and simpler route to dispose of the greenhouse gas to help tackle global warming.
28 Sep 2021
Researchers at Kanazawa University report in Science Advances a new method for distinguishing between enantiomers, molecules that are mirror images of each other. The procedure, relevant for the pharmaceutical industry, involves the chemical reaction of target enantiomers with color indicator compounds consisting of one-handed helical polymers, leading to solutions showing different colors in specific solvents between the enantiomers.
16 Sep 2021
A new approach leads to the long-awaited formation of rings made of three pyrroles, which could be used to produce compounds with a host of interesting properties, and explains why they have not been observed before.
27 Jul 2021
Adding lead and calcium to an industrial catalyst dramatically improves its ability to support propylene production at very high temperatures, making it stable and active for a month.
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Associate Prof. Yusuke Ishigaki is a chemist at Hokkaido University, Japan. He works on the creation of fundamental chemistry based on original molecular design.
Dr. Omachi is Associate Professor, Research Center for Materials Science, Nagoya University
Giants in history
Indian organic chemist Asima Chatterjee (1917 to 2006) studied the medicinal properties of plant products, especially compounds known as vinca alkaloids.
Osamu Shimomura (27 August 1928 – 19 October 2018) was a Japanese organic chemist and marine biologist who dedicated his career to understanding how organisms emitted light.