Chemistry Organic chemistry

News

The chemical structure and solids crystals of calix[3]pyrrole (Photo: Inokuma Laboratory).
16 Sep 2021
A new approach leads to the long-awaited formation of rings made of three pyrroles, which could be used to produce compounds with a host of interesting properties, and explains why they have not been observed before.
The newly developed catalyst in powder form (left) and under a transmission electron microscope (right)
27 Jul 2021
Adding lead and calcium to an industrial catalyst dramatically improves its ability to support propylene production at very high temperatures, making it stable and active for a month.
07 Jul 2021
We have developed a groundbreaking chemical reaction using an N-heterocyclic carbene catalyst that has a low environmental impact to cleave the bond between the benzene ring of an aryl halide and a halogen atom to generate an aryl radical. Since aryl radicals can thus be easily generated from aryl halides that are widely used in organic synthesis, this is expected to be a powerful technology for precisely synthesizing medical and agricultural drugs and chemical materials.
Ball-milling the mixture of polystyrene and pre-fluorescent radical reactants yielded luminescent polymers. Photos show the mixture before (left) and after (right) the reaction, under UV light.
11 Jun 2021
Hokkaido University researchers have developed a simple method that converts existing generic polymers into luminescent polymers using mechanical force.
1,3-Diradicals Embedded in Curved Paraphenylene Units: Singlet versus Triplet State
09 Jun 2021
Chemical rings of carbon and hydrogen atoms curve to form relatively stable structures capable of conducting electricity and more — but how do these curved systems change when new components are introduced? Researchers based in Japan found that, with just a few sub-atomic additions, the properties can pivot to vary system states and behaviors, as demonstrated through a new synthesized chemical compound.
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02 Jun 2021
Scientists have found a way to make hydrogen move faster through a solid material at cooler temperatures, paving the way for more sustainable and practical energy storage devices.
Insoluble reactants are hardly reactive in solution, but may react in solvent-free systems using ball milling to drive chemical reactions in the solid state
18 May 2021
Scientists from Hokkaido University have developed a rapid, efficient protocol for cross-coupling reactions, vastly expanding the pool of chemicals that can be used for the synthesis of useful organic compounds.
03 Mar 2021
Osaka City University finds that the chemical sesaminol, naturally occurring in sesame seeds, protects against Parkinson’s disease by preventing neuronal damage that decreases the production of dopamine. In vitro experiments show sesaminol handle oxidative stress in cells by regulating the production of reactive oxygen species and the movement of antioxidants. In vivo experiments reveal that a diet of sesaminol increases production of dopamine and significantly improve motor functions in mice.
20 Aug 2020
A new catalyst design enables unprecedented control over the modification of fatty acid derivatives that opens the door to creating useful substances in a green and efficient manner.
14 Aug 2020
In catalytic reactions with organocatalysts, it is difficult to control radical reactions. We designed a thiazolium-type N-heterocyclic carbene catalyst having an N-neopentyl group. This catalyst was found to actively control radical reactions and enabled production of more than 35 species of bulky dialkyl ketones from an aliphatic aldehyde and an aliphatic carboxylic acid derivative through a radical relay mechanism. This catalyst is expected to open the way for acceleration of drug discovery research.
28 May 2020
The generation of alkyl radicals was achieved by direct visible-light excitation of the organoborate complex, which was designed and synthesized from “boracene,” which has a boron atom in the tetracene-like skeleton. The alkyl radicals thus obtained could be used as a carbon source for chemical reactions, enabling the synthesis of complicated/bulky organic compounds. The present study offers a new protocol for organic synthesis, which is expected to accelerate e.g. drug discovery.
iCeMS_horike_chemcsi
13 May 2020
Hydrogen fuel cells made with coordination polymer glass membranes could produce as much energy as their liquid-based counterparts while adding strength and flexibility.
05 Mar 2020
Molecular changes could improve the efficiency of next-generation photovoltaics.
Palladium nanoparticles in reaction mixtures
08 Feb 2019
Adding olefin enables efficient solvent-free cross-coupling reactions, leading to environmentally friendly syntheses of a wide range of organic materials.

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Researchers

Associate Prof. Yusuke Ishigaki is a chemist at Hokkaido University, Japan. He works on the creation of fundamental chemistry based on original molecular design.
Dr. Omachi is Associate Professor, Research Center for Materials Science, Nagoya University