Health

Scientists identified a protein that regulates cellular clean-up, could also hold the key to new treatments for age-related muscle loss and muscle wasting in cancer patients, enhancing quality of life.

The Androgen Receptor in Mesenchymal Progenitor Cells Drives Skeletal Muscle Mass Regulation

A research team led by Osaka University has developed Japan's first biomolecular sequencer prototype, crucial for gene-based cancer diagnosis and treatment. After 16 years of research, the team, led by Professors Taniguchi and Ohshiro, collaborated with H.U. Group Research Institute and Sony Global Manufacturing & Operations Corporation to overcome technical challenges. The team plans to enhance the device with AI for accurate diagnostics and to advance peptide drug discovery.

By targeting multiprotein molecule, antibody inhibits bacteria’s growth, pathogenicity

• Two-year assessment provides critical insights and recommendations for strengthening genomic sequencing for infectious disease surveillance in 13 South and Southeast Asian countries. • Research helps to step up Asia’s preparedness across wide range of diseases.

Incidence, risk factors found for pulmonary aspergillosis, an invasive fungal infection of lungs, among COVID-19 patients

A research group has developed a new COVID-19 testing system using Janus particles—microparticles with two sides possessing distinctive molecular properties. These particles are engineered to bind specifically to target antigens, such as viral proteins, creating a low-cost, accurate, and rapid means of testing for viral diseases. The system’s versatility means it can potentially be used to test for other diseases and biomarkers linked to other conditions.

Learned society and publisher Applied Microbiology International (AMI) has announced a new partnership with science communicators SelectScience. The two organisations will be working together on SelectScience’s upcoming CLINICAL24 campaign and beyond.

A recent study from Osaka University reveals that intensive diabetes treatment can improve periodontal disease inflammation. Researchers found that two weeks of intensive diabetes treatment under hospitalization for patients with type 2 diabetes significantly improved not only blood sugar control but also PISA, an indicator of gum disease inflammation. Furthermore, the improvement in PISA was related to factors such as insulin secretion capacity and the severity of diabetes complications and comorbidities before diabetes treatment. These findings suggest that early intervention in diabetes is crucial for improving gum disease in diabetic patients.

Researchers from Osaka University found that T cells recognize neoself-antigens––abnormal, unfolded host proteins presented by major histocompatibility complex II (MHC-II) lacking the invariant chain––as non-self antigens, leading to the development of autoimmunity. Reactivation of Epstein–Barr virus, a known risk factor for lupus onset and exacerbation, increases the presentation of neoself-antigens by MHC-II, which could help explain the link between viral infection and autoimmune disease.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are a computer chip inspired by our brains, the potential link between asthma and diabetes, and how Japanese eels flee their predators after being swallowed.

Whether immunotherapy or conventional chemotherapy carries less mortality risk depends on BMI

Seaweed helps brain health, Whales in long-distance relationships, Jumpstarting male fertility, Demystifying black hole turbulence, Shrimp to steel & Mpox Resources. Read all in the latest Editor's Choice.

Suppression of an enzyme might allow melanocytes to recover

Lingnan University has admitted three elite student-athletes through the Direct Entry Stream for Top Athletes (DESTA) for the 2024/25 academic year. The successful candidates cyclist Ng Sum-lui, Wushu Sanda athlete Li Ka-yee, and ice hockey player Patten Lai have achieved outstanding results in their respective sports. Since the scheme was launch in the 2022/23 academic year, Lingnan University has accepted a total of eight elite athletes.

Feeder-free induced pluripotent stem cells hold hope in therapies for cats’ chronic kidney disease

A study highlights that children with ADHD frequently experience sleep problems, potentially linked to lower levels of melatonin, a hormone crucial for regulating sleep. Genetic variations that reduce melatonin levels at night are associated with more severe ADHD symptoms in children aged 8-9. The research suggests that improving sleep habits, such as increasing morning sunlight exposure and reducing evening screen time, could help manage ADHD symptoms. This underscores the importance of addressing sleep issues as a possible way to alleviate ADHD symptoms in children.

Survey of 10,000 Japanese adults reveal leading causes of burp-related disorders

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are how choosing the right drink can reduce your chance of developing gout, how warmer waters mean tougher conditions for some fish, and combining crystals with dye to reinforce anti-counterfeit labels.

Specific nucleosides hinder replication of tumor cells in step toward cancer prevention

TechInnovation 2024, IPI Singapore’s flagship event, is set to return this year from 28 - 30 October at Marina Bay Sands, Level 4, Roselle-Simpor Ballroom, as a premier event dedicated to exploring Sustainable Urban Living.

Researchers from Osaka University found that voltage-sensing phosphatase (VSP) is activated by electrical signals during sperm maturation and is crucial for establishing the optimal phosphoinositide environment to generate functional spermatozoa. Modulating VSP function to promote appropriate sperm maturation could be used to develop clinical treatments for infertility in the future.

A nonirritant, antibacterial solution to prevent oral inflammation may lie in citrus and coconut chemical compounds

A pioneering study titled “Causal effect of video gaming on mental well-being in Japan 2020-2022,” published in Nature Human Behaviour, has conducted the most comprehensive investigation to date on the causal relationship between video gaming and mental well-being. This research, the first to demonstrate this relationship using real-life data, challenges commonly held views about the effects of gaming.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are how playing video games can help you feel better, how we age rapidly in two “bursts”, and a spider that tricks male fireflies into its web.

This alliance by the student bodies of Singapore’s three medical schools continues to unify and represent the voice of the local medical student community through regular dialogue, engagement and collaboration with external stakeholders, including the Singapore Medical Association and Ministry of Health.

A newly developed compound that reduces harmful inflammation in rats caused by overactive neutrophils shows great potential as a safer treatment for various inflammatory diseases in humans.

ChatGPT’s diagnostic capabilities evaluated in comparison to radiologists

Researchers from Osaka University developed an antibody that prevents the activation of the Dickkopf 1–Cytoskeleton-associated protein 4 (DKK1–CKAP4) pathway, which is important for tumor growth in several cancers, including pancreatic cancer. On the basis of an antibody derived from mice, the researchers developed an antibody that could be used in humans (Hv1Lt1). Hv1Lt1 successfully prevented tumor formation in experimental mice. When given in combination, it improved the effect of chemotherapy drugs.

A clinical trial conducted by Tohoku University researchers has lead to the approval of a treatment for patients with a rare, muscle-weakening disease called GNE myopathy.