Medicine

UOsaka and MIT scientists revealed that the motor proteins KIF18A and CENP-E work together to align chromosomes during mitosis. Cancer cells with reduced CENP-E levels are especially sensitive to KIF18A inhibition, and dual inhibition of both proteins leads to efficient cell death. The discovery offers new insights into chromosome mechanics and a potential strategy for targeted cancer therapy.

Researchers from The University of Osaka have found that rituximab, a monoclonal antibody approved for the treatment of nephrotic syndrome in children in Japan, also improves disease management in adults. The drug kept adults with frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome relapse-free for longer, compared with placebo, with good safety. By reducing the frequency of relapses, rituximab may reduce the reliance on corticosteroids and help to improve quality of life among adult patients with these challenging conditions.

Researchers successfully treat spinal compression fractures using stem cells from fatty tissue

Researchers at National Taiwan University have discovered how light, electricity, and tiny forces can work together to help wounds heal naturally and leave fewer scars, offering new hope for chronic wound care.

Female individuals may experience a three-fold reduction in mortality risk from coronary heart diseases, when following recommended exercise guidelines, compared to male individuals, according to a study published in Nature Cardiovascular Research.

A new study suggests that the same henna pigments that change your skin or hair that distinctive orange-red color could be used for another purpose: treating liver disease.

Researchers have developed a novel biomedical engineering tool that uses volumetric MRI analysis to precisely measure paraspinal muscle atrophy, distinguishing nerve root severities in traumatic brachial plexus injuries with 91% accuracy. The new evaluation system outperformed standard clinical assessments and shows promise for diagnosing degenerative radiculopathy, potentially enabling early detection of chronic nerve compression.

Lab tests confirm that Pin1 inhibitors could reduce and stop outbreaks of herpes simplex virus-1

SOSE researchers are looking at a possible vaccine for H. pylori, a widely common bacterium that causes stomach ulcers and raises the risk for stomach cancer.

Scientists from National Taiwan University have created a new light-based imaging technology that can trace a person’s blood sugar history by analyzing individual red blood cells. This breakthrough could improve diabetes care and help detect certain cancers earlier through simple, noninvasive testing.

Researchers at The University of Osaka discovered that the protein TMEM217 is essential for sperm motility and male fertility. TMEM217 stabilizes a protein complex that produces the signaling molecule cAMP, which powers the sperm’s tail. Mice lacking TMEM217 have immotile sperm, but treating the sperm with a cAMP-like molecule restored motility and fertility via IVF. This finding opens doors for new diagnostics and therapies for male infertility.

Researchers from The University of Osaka in collaboration with Baylor College of Medicine have developed a new therapy for a severe form of male infertility called non-obstructive azoospermia (NOA). Using lipid nanoparticles (LNPs) to deliver specific mRNA into the testes of infertile mice, they were able to restart sperm production. The sperm produced were then used in intracytoplasmic sperm injection (ICSI) to successfully generate healthy and fertile offspring. The findings provide a crucial proof-of-concept for treating male infertility caused by genetic defects.

Ateneo de Manila University and Science Communicators Philippines explored how scientific knowledge can be better shared, understood, and applied for the public good.

Researchers at The University of Osaka have discovered precursor T follicular regulatory cells (preTfr), comprising 30-50% of circulating Tfr in human blood. preTfr are significantly reduced in severe COVID-19 and sepsis, correlating with increased anti-interferon-gamma autoantibodies and activated atypical B cells. Unlike stable conventional naïve regulatory T cells, preTfr are specifically depleted during severe disease. When stimulated, preTfr up-regulate suppressive molecules including IL-1RA and show enhanced wound healing capacity. Conversely, mRNA vaccination increases preTfr frequency, suggesting controlled immune participation. The findings identify preTfr as a therapeutic target for preventing autoantibody production during severe infections.

Researchers investigated how autoimmune gastritis alters the gastric microbiota and disrupts metabolism, shedding light on mechanisms that contribute to the development of neuroendocrine tumors.

Ancient black holes, How good cholesterol is made, Self-healing plastic, Dengue’s genetic imprint, Korean mussel power & Space clean-up. Read all in the latest Editor's Choice.

National Taiwan University researchers uncover how silencing a single protein protects the brain and extends lifespan.

Commuting time and living environment have been found to correlate with poor sleep health

A new study led by National Taiwan University Hospital (NTUH) researchers shows that while scarless thyroid surgery preserves delicate structures better, it requires longer operative time, higher costs, and may compromise specimen integrity.

A Kyoto University study has revealed, for the first time, how the body produces the “good cholesterol” that can prevent heart disease

High-grade gliomas pose formidable challenge clinically due to poor prognosis and high recurrence rate. Principal investigator Prof. Feng-Huei Lin and research scientist Dr. Jason Lin from National Taiwan University have designed a novel injectable gel against high-grade gliomas, which delivers platinum-based chemotherapeutic agents in two stages, including immediate release of carboplatin and delayed release of platinum from platinum-doped calcium carbonate. This time-release gel synergizes subsequent radiotherapy, suppressing tumor relapse while reducing radiation side effects. It offers a promising approach to improving brain cancer treatment.

This innovative technique allows for precise measurement of brain activity without the need for open-brain surgery by using blood vessels as conduits for electrodes. This holds immense potential for improving neurological care, advancing our understanding of the brain, and unlocking new possibilities for brain-computer interfaces.

Combined effects of body cooling and mental fatigue hinder endurance performance

Increases in wildfires, linked to projected future climate change, are expected to cause a notable increase in premature deaths, according to two new modelling studies.

Researchers at Osaka Metropolitan University have developed an AI model for diagnosing esophageal achalasia using chest X-rays. The AI model demonstrated higher sensitivity and specificity than physicians in its diagnostic capability.

Researchers at The University of Osaka and Kanazawa University have developed a novel method for analyzing cancer metabolism, revealing new insights into cancer's inefficient energy process. This breakthrough, published in Metabolic Engineering, combines biological experiments with advanced information science techniques to uncover the role of cancer-specific inefficient metabolism.

Researchers in Vietnam, Thailand, India and the UK have been awarded more than £4 million by the National Institute for Health and Care Research (NIHR) to identify and evaluate inclusive methods of healthcare provision.

Researchers from National Taiwan University Hospital and Academia Sinica have identified a simple blood marker that can reliably pinpoint chronic hepatitis B (CHB) patients at negligible risk of developing liver cancer.

Researchers have identified the mechanism by which a common genetic mutation increases liver disease risk. Their findings suggest that healthy choices, such as increasing antioxidants and limiting exposure to smoke, may reduce the risk of this disease.

An international research group led by The University of Osaka has developed scODIN, a novel computational tool to classify cell types from single-cell RNA sequencing (scRNA-seq) data. Existing methods struggle to balance speed and accuracy, often misclassifying rare or transitional cells. scODIN overcomes this limitation by combining a hierarchical classification system (Tier system) with k-nearest neighbor inference. This approach allows for the rapid and accurate classification of large datasets, processing 650,000 cells in just six minutes. The tool's improved accuracy stems from its ability to identify cells at varying levels of detail, recognize intermediate phenotypes through double labeling, and recover cells affected by dropout events. scODIN promises to accelerate biomedical discoveries by enabling more precise and efficient analysis of complex biological processes and disease mechanisms.