Medicine

The researchers from Osaka University showed how bone erosion caused by cholesteatoma occurs. This study showed that a subset of cells called osteoclastogenic fibroblasts expresses a protein, activin A, which causes the breakdown of the bones. Because of this discovery, novel medical treatments can be developed as first-line management for cholesteatomas.

Researchers from Osaka University found that patients with persistently high levels of urinary albumin excretion in the long term are at high risk of new-onset heart failure. Preventive treatment associated with the lowering of urinary albumin excretion levels in these patients could reduce the risk of later heart failure or mortality.

Researchers from Osaka University have demonstrated a proof-of-concept for identifying single nucleotides by using quantum computing. Molecular rotation patterns—and the corresponding variations in conductance—within the nanoscale gap between two electrodes enabled the development of a quantum gate for the nucleotide adenosine monophosphate. Developing quantum gates for the other three nucleotides, and incorporating this technology into DNA sequencing workflows, could revolutionize genome analysis.

Scientists have isolated potent neutralising antibodies from a COVID-19 vaccinated SARS survivor that exhibited remarkable breadth against known sarbecoviruses. The antibodies targeted a conserved region of the spike protein and blocked receptor binding and viral fusion. These findings could guide the development of broadly active therapeutics against current and future coronaviruses.

The consortium’s multidisciplinary executive committee comprises of both local and international oral health researchers.

The Centre for Chinese Herbal Medicine Drug Development (CDD) of Hong Kong Baptist University (HKBU) has made significant progress in developing novel Chinese medicine for treating chronic constipation. With its success in the Investigational New Drug Application to the U.S. Food and Drug Administration (FDA), CDD has been authorised to conduct a phase I clinical trial of the new drug. This is the first time that a new botanical drug developed in Hong Kong was authorised to conduct a clinical trial in the US.

Lactate is a byproduct of exercise and metabolism, fueling our brain when oxygen is limited. More recently, scientists have become aware of the many roles it plays in developing our nervous system. Now, researchers from Tohoku University have unearthed the cellular mechanisms by which lactate helps our brains develop.

Scientists have combined two light wavelengths to deactivate a bacterium that is invulnerable to some of the world’s most widely used antibiotics, giving hope that the regime could be adapted as a potential disinfectant treatment.

RNases have been proposed as a treatment against systemic autoimmune diseases. Researchers from Osaka University showed that RNases have a dual action. In some cases, RNases are detrimental and stimulate the immune response by promoting the binding of antibodies to their targets. These findings will improve the understanding and treatment of systemic autoimmune disorders.

Researchers from Osaka University have developed a fluorescent sensor that may be useful for understanding how cells recognize themselves versus other cells when making connections in the brain. Specifically, their sensor can be used to visualize not only connections between cells, but also the disassociation of these interactions. Because neuronal self-connectivity has been implicated in brain disorders like epilepsy and autism, a better understanding of this process may result in improved therapies.

A research team has discovered an astounding array of unexplored protein folds. This research will expand our understanding of the depth of the protein universe and the possibilities for de novo design of functional proteins.

The physiological mechanisms underlying severe burns are not well understood. Researchers at Osaka University used mass spectrometry to identify key blood proteins associated with burn mortality. Ultimately, three proteins (HBA1, TTR, SERPINF2) were very highly correlated with morality rates. Further research into these proteins and their pathways may lead to better drugs to treat people with life-threatening burns.

The entire biosynthetic pathway of actinopyridazone has been unveiled, revealing that an unprecedented carrier protein-mediated ring-forming step is key to its synthesis.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are a way to avoid biopsies by catching free-floating DNA, a large dip in the Earth’s surface under the Indian Ocean, and how people who brush their teeth before bed seem to have healthier hearts.

Osaka Metropolitan University scientists have successfully developed a model that utilizes AI to accurately classify cardiac functions and valvular heart diseases from chest radiographs. The Area Under the Curve, or AUC, of the AI classification showed a high level of accuracy, exceeding 0.85 for almost all indicators and reaching 0.92 for detecting left ventricular ejection fraction—an important measure for monitoring cardiac function.

A group of researchers at Osaka University used a noninvasive method to evaluate Cerebrovascular Autoregulation (CVAR) in patients after out-of-hospital cardiac arrest. The mortality rate increased significantly with the duration of time that CVAR was undetectable. It has been suggested that CVAR, a function that is normally present in the normal state, may be impaired after cardiac resuscitation. However, the relationship between CVAR function and patient prognosis has been unclear. The research examined CVAR over time, using the moving Pearson correlation coefficient calculated from regional cerebral oxygen saturation and mean blood pressure data, and performed a survival analysis using the presence or absence of CVAR as a time-dependent covariate. The findings of this study may first be useful in predicting neuroprognosis after cardiac resumption and may help avoid early withdrawal of treatment in those who may recover. In addition, they suggest that treatment and management that maintains proper CVAR after cardiac resumption may improve patient prognosis, which may be applied to the management of post-cardiac arrest resuscitation based on cerebral circulation to optimize treatment for each individual patient.

Researchers from Osaka University have revealed the mechanism by which increased signaling through a pathway associated with a molecule called Wnt leads to the development of liver cancer. They identified a gene called GREB1 as a target of Wnt specifically in liver cancer. This gene alters the function of a protein called HNF4α, leading to the development of cancer. They also showed that treatment of mice with antisense oligonucleotides against GREB1 had significant anti-cancer effects.

What scientists learned about the rare antibodies targeting SARS-CoV-2’s Achilles’ heel could help fine-tune our COVID-19 vaccine strategy for longer-lasting immunity.

An international team led by Professor Yan Xu from Osaka Metropolitan University has developed a groundbreaking nanofluidic device, named NANa, capable of stochastically capturing and digitally detecting individual proteins at cellular concentrations. This tool, vital for precision medicine, is designed to handle tiny volumes equivalent to a single cell's contents and can identify single biomolecules even in high-concentration environments. The team plans to conduct further demonstrations using actual cell samples and explore the integration of this tool with AI and biological big data. This research could potentially revolutionize personalized disease prevention and treatment.

A combination of radiotherapy followed by immunotherapy is a promising strategy for the treatment of oral malignant melanomas in dogs.

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Researchers from Osaka University found that the binding of two proteins—Polydom and Tie1—is essential for lymphatic cell migration in the remodeling of lymphatic vessels, which transport molecules around the body. A better understanding of the development and remodeling of the lymphatic system will lead to better therapeutic options for diseases such as lymphedema, which is common in cancer patients and currently has no cure.

A joint research group led by Osaka Metropolitan University has clarified how pathogenic genes in some Providencia spp., which have gained attention as causative agents of food poisoning as well as enterohemorrhagic Escherichia coli. O157 and Salmonella, are transferred within bacterial cells. Their findings are expected to provide new insights into the identification of infection routes of Providencia spp. and the establishment of preventive methods for food poisoning.

A stem cell therapy treatment developed by Duke-NUS Medical School researchers for heart failure has shown promising results in preclinical trials. These cells, when transplanted into an injured heart, are able to repair damaged tissue and improve heart function.

Researchers from Osaka University developed an in vivo CRISPR screen to analyze factors affecting Toxoplasma gondii fitness in healthy and immunodeficient mice. Mice were infected with Toxoplasma containing CRISPR libraries that targeted specific genes; genetic sequencing was then performed to identify which genes are important to fitness. The genetic screen clarified the contributions of host genetics and parasite genetics and can contribute to the development of strategies for toxoplasmosis treatment and prevention.

App leads to better birth preparation for pregnant women

Tests could soon identify patients who will respond well to the available treatment for chronic myeloid leukaemia and those who will be resistant to it—which could improve their chances of survival.

Zinc is essential for our health. Our bodies must constantly regulate its zinc levels, otherwise fatal diseases such as cancers, growth failures, ad immunodeficiency can occur. Now, a research group has unearthed how zinc transporter complexes regulate zinc ion concentrations in different areas of the Golgi apparatus.

Truck drivers unintentionally taking ‘microsleeps’ of a few seconds can cause terrible traffic accidents, but efforts and technologies aiming to prevent the problem have focused mainly on monitoring driver eye activity while missing a host of other key indicators of the problem.

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