Medicine

An international research group led by The University of Osaka has developed scODIN, a novel computational tool to classify cell types from single-cell RNA sequencing (scRNA-seq) data. Existing methods struggle to balance speed and accuracy, often misclassifying rare or transitional cells. scODIN overcomes this limitation by combining a hierarchical classification system (Tier system) with k-nearest neighbor inference. This approach allows for the rapid and accurate classification of large datasets, processing 650,000 cells in just six minutes. The tool's improved accuracy stems from its ability to identify cells at varying levels of detail, recognize intermediate phenotypes through double labeling, and recover cells affected by dropout events. scODIN promises to accelerate biomedical discoveries by enabling more precise and efficient analysis of complex biological processes and disease mechanisms.

Researchers from The University of Osaka found that the radial spoke protein CFAP91 is crucial for flagellum formation in sperm, and that the proximal protein EFCAB5 is important for sperm motility. Loss of function of either of these proteins impairs spermatogenesis, suggesting that their mutation or loss can lead to male infertility.

Standard blood tests can help physicians predict the risk of mortality in patients with Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). These findings may facilitate earlier interventions and enable more personalized treatment strategies for this severe cutaneous adverse reaction (SCAR).

Researchers at National Taiwan University have discovered a versatile enzyme from Bacillus subtilis that efficiently attaches phosphate groups to natural compounds. This breakthrough offers a greener way to boost drug solubility and develop more effective nutraceuticals and prodrugs.

• Singapore’s flagship medical school is doubling down on population health research and technology-enabled solutions to strengthen healthcare systems and prepare tomorrow’s leaders • The School rebrands its Health Services & Systems Research (HSSR) programme to deliver policy-relevant, tech-driven solutions for a healthier Singapore • Launches new education pathways to enhance professional capabilities in population health research

Magnetic resonance imaging often yields inconsistent results when assessing the brain’s structural characteristics in children with attention deficit/hyperactivity disorder (ADHD). To address this, scientists from Japan have used a harmonization method called traveling-subject (TS) to reduce measurement bias in brain imaging datasets from multiple sites. The TS harmonized datasets showed significant reductions in measurement bias and revealed apparent volumetric changes in specific brain regions, indicating promise for developing a more robust diagnosis for ADHD.

The research group led by Drs. Mitsuru Arase, Mari Murakami, and Prof. Kiyoshi Takeda (Graduate School of Medicine/ Immunology Frontier Research Center at The University of Osaka) revealed that transcription factors RUNX2 and BHLHE40 play crucial roles in inducing T cells involved in Crohn's disease.

Japanese encephalitis virus (JEV) vaccination both prevents JEV and lowers dengue severity.

A customizable protein has been developed to help the body remove harmful cells, such as those involved in cancer or autoimmune diseases, offering a potential new direction for treatments.

Researchers from The University of Osaka have found that they can keep mouse uterine tissue alive outside of the body, allowing them to directly observe embryonic implantation and development. Their technique brings hope for patients with infertility, and may allow for the development of therapies to treat recurrent implantation failure and improve the chance of implantation success using assisted reproductive technologies.

Researchers from The University of Osaka found that macrophages use microautophagy, mediated by Rab32-positive lysosome-related organelles, to directly engulf damaged mitochondria and other organelles. This was discovered to be independent of macroautophagy. Key factors in this process include Rab32 GTPase, PI(3,5)P2, ubiquitination, and p62/SQSTM1. By clearing mitochondria, microautophagy promotes metabolic reprogramming toward glycolysis, supporting M1 macrophage polarization. Loss of Rab32/38 disrupts this process, highlighting microautophagy’s role in regulating macrophage function.

A drug called lubiprostone - typically used for constipation - was remarkably shown to help patients with chronic kidney disease.

By analyzing outcomes from a large-scale national dataset, this study raises tough questions about the impact of pre-hospital life support procedures on outcomes in patients with asystole.

Taiwanese research team provides important new evidence on diabetes medications' respiratory outcomes, with implications for patients with dual chronic conditions.

A research group led by The University of Osaka has discovered that the DNA repair enzyme Polβ plays a crucial role in protecting the developing brain from harmful mutations. The study found that a lack of Polβ leads to a significant increase in small insertions and deletions of DNA, known as indels near CpG sites, which are important regulatory regions in genes. This accumulation of mutations could contribute to neurodevelopmental disorders.

Studies have found that natural polysaccharides from Taiwan's national treasure "Antrodia", after specific treatment, can not only effectively inhibit inflammation, but also fight the proliferation of lung cancer cells.

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Discovery of new therapeutic effects induced by CAR-T cell therapy

Prof. Fang-Jen S. Lee's team at National Taiwan University discovered that an intermediate cellular metabolism molecule, glycerol, regulates the localization and function of the Golgi protein Imh1, thus revealing a previously unappreciated connection between cellular metabolism and vesicular transport.

Scientists found three language-model chatbots — even with advanced prompt‐engineering tricks — often give suboptimal guidance across stroke prevention, diagnosis, treatment and recovery, highlighting the need for human oversight to ensure appropriateness and safety.

A research team at National Taiwan University has developed a new stem cell-based vaccine that could help prevent and treat colorectal cancer.

Bacteria in the digestive system may work to maintain balance directly and indirectly

A group of researchers led by The University of Osaka have identified a novel genetic mutation in Streptococcus pyogenes, a common bacterium which causes strep throat, significantly associated with severe invasive infections. A single mutation in the bacterial ferric ion transporter enhances bacterial growth in human blood. This mutation, unique to Japanese isolates, indicates a novel pathogenic mechanism. This world-first discovery offers a potential new target for treatments and preventive measures.

Researchers from The University of Osaka have used a miniature heater positioned over a nano-sized opening to gently unzip DNA’s double helix into a single strand for quick, efficient analysis. The device enables detection of longer DNA strands than before while using less power and improving accuracy. The technology could be used in handheld medical devices, helping doctors to diagnose disease and tailor treatments based on patients’ genes.

A research team from National Taiwan University, Academia Sinica, and National Taiwan University Hospital has uncovered a critical connection between a unique RNA molecule and human aging, including early-stage Alzheimer’s disease.

Researchers are one step closer to finding a common target for treating ALS - a fatal neurodegenerative disease that causes progressive muscle weakness.

Singapore-led study shows specialised support cells in the gut form direct, neuron-like connections to deliver precise instructions to stem cells; Overturns long-held beliefs about how gut cells communicate; Opens new paths for treating colon cancer and IBD

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A 3D paper-based analytical device (3D-osPAD) with in situ gold signal amplification enables one-step, highly sensitive detection of anti-IFN-γ autoantibodies within 10 minutes, showing 10-fold improved sensitivity and high clinical accuracy for adult-onset immunodeficiency..