Medicine

Hunting for supermassive black holes, Coastal survival at risk, Calcium and dead cell clean-up, Two naps are better than one & Pineapple leaf prosthetics. Read all in the latest Editor's Choice.

Osaka Metropolitan University researchers have used the power of laser light to accelerate the reaction between cancer cell-derived extracellular vesicles—a kind of nanoparticle—and antibody-modified microparticles. The three-dimensional structure of the resulting aggregates was then analyzed using a confocal optical system. The results demonstrated the ability to measure, within 5 minutes, approximately 1,000 to 10,000 nanoscale EVs contained in a 500 nL sample.

The authors discovered a shorter isoform of Rubicon called RUBCN100, which enhances autophagy in B cells.

The authors identified a structure in the circadian mRNA Period2 that affects the sleep-wake cycle. The results indicate how translation and post-transcriptional processes influence the body’s internal clock and its impact on sleep patterns.

Researchers led by Osaka University developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of enzyme that makes single-stranded “nicks” in the DNA. Repair of these nicks is more efficient and accurate than repair of double-strand breaks caused by the current CRISPR/Cas9 editing. This technique represents a novel approach for the treatment of genetic diseases caused by heterozygous mutations.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are a previously unrecorded species of ant found in someone’s backyard, comparing traditional medicine to drugs for indigestion, and how breastfeeding can help babies develop a healthy gut.

This novel technology: - provides potential treatment in relation to restoring aging muscle cells obtained from older adults and remedying sarcopenia in aging animals through bioelectric medicine - presents a new paradigm for treating sarcopenia, for which no drugs are currently available to treat this condition - has been reported in the internationally renowned academic journal, Proceedings of the National Academy of Sciences (PNAS)

A reanalysis of studies on night shift naps reveals the ideal snoozing schedule that may help combat fatigue and drowsiness when staying up all night.

Scientists have found that extracellular calcium mediates the activation of a membrane protein that waves the flag signalling cell death

AXL and EGFR inhibitors combined hold promise in fighting certain head, neck, and lung cancers

Capturing carbon dioxide, Shells go nuclear, Worms surf electric fields, Brain repair & Creating matter from light. Plus from our blog: Monitoring research for further impact. Read all in the latest Editor's Choice.

Researchers from Osaka University have revealed that the expression of a specific isoform of GREB1 Is4 is induced in malignant melanoma cells by the melanocyte-specific transcription factor, MITF. They revealed that GREB1 Is4 stimulates pyrimidine biosynthesis and promotes cancer cell proliferation. Furthermore, the anti-tumor effect of antisense nucleic acids against GREB1 showed a potential new modality for malignant melanoma.

Researchers at Kanazawa University report in Cell Reports how alterations in the nuclear pores lead to the degradation of anti-tumor proteins.

Roughly 10% of the proteins in our body rely on zinc. A group of researchers has unearthed the secrets behind a tiny but crucial protein that shuttles zinc ions within our bodies, offering a deeper understanding of how our cells maintain optimal health.

How much is adequate screen time for a child? It is the question at the forefront of many parents’ minds. Now, a recent cohort study has found that the amount of screen time spent by one-year-olds is associated with developmental delays.

It is the first local research and innovation platform enabling Primary Care Professionals from public and private healthcare to deliver stronger primary care and improve patients’ health outcomes

Osaka Metropolitan University scientists have verified the anticancer effects of Kencur, a tropical plant of the ginger family, mainly grown in Southeast Asia, in cell and animal experiments. They found that Kencur extract and its main active components significantly inhibit cancer cell growth at the cellular and animal levels. Furthermore, the involvement of TFAM in the mechanism of action was confirmed.

Deepak Verma from Chulalongkorn University and his international team of researchers are exploring ways to enhance chitosan using techniques like adding photosensitizers, dendrimers, and chemical modifications. They also surveyed the use of chitosan nanoparticles for medical purposes, notably wound dressings.

Anti-estrogenic therapies can suppress the growth of cancer that does not express estrogen receptors; when combined with immune checkpoint inhibitor therapies, they halt tumor progression in mice models.

Japanese fossil forest found, AI finds a way to people’s hearts, Language diversity and child social development & Supplement for kidney disease. Plus Submissions open for Asia Research News 2024. Read all in the latest Editor's Choice.

Osaka Metropolitan University scientists have developed an AI model that accurately estimates a patient’s age, using chest radiographs of healthy individuals collected from multiple facilities. Furthermore, they found a positive relationship between differences in the AI-estimated and chronological ages and a variety of chronic diseases, such as hypertension, hyperuricemia, and chronic obstructive pulmonary disease. In the future, it is expected that AI biomarkers will be developed to predict life expectancy, estimate the severity of chronic diseases, and forecast surgery-related risks.

A research team co-led by City University of Hong Kong (CityU) and The University of Hong Kong (HKU) has recently made a significant advancement in spinal cord injury treatment by using genetically modified human neural stem cells (hNSCs). They found that specifically modulating a gene expression to a certain level in hNSCs can effectively promote reconstruction of damaged neural circuits and restore locomotor functions, offering great potential for new therapeutic opportunities for patients with spinal cord injury.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are particle pollution linked to antibiotic resistance and microplastics being found in the body, fossils that show a marine reptile that used filter feeding, and how a connection in our brains compares our rewards to ones that others received.

Researchers from Osaka University clarified the interactions of the proteins Tejas (Tej), Vasa (Vas), and Spindle-E (Spn-E) in the formation of cellular compartments known as nuage and the processing of PIWI-interacting RNA (piRNA) precursors in Drosophila melanogaster ovaries. piRNAs help prevent the transmission of genetic mutations through reproductive cells, and insight into the dynamics of piRNA formation and processing may contribute to our understanding of the mechanisms underlying reproductive disorders, including infertility.

A research led by scientists of Hong Kong Baptist University (HKBU) found that isoliquiritigenin (ISL), a flavonoid isolated from the Chinese herbal medicine licorice, can inhibit pancreatic cancer progression. It may also enhance the efficacy of conventional chemotherapeutic drugs in treating pancreatic cancer. It is the first time that a research group reported the anticancer potential of ISL in treating pancreatic cancer.

Osaka Metropolitan University scientists tested the antiobesity effects of Mallotus furetianus extract native to Hainan Island, China, using obesity model mice. As a result, body weight and adipose tissue weight of obesity model mice were significantly reduced by the intake of Mallotus furetianus extract. Fatty liver was suppressed and adipocyte size reduction in adipose tissue was observed. Further investigation into the mechanism revealed that fat synthesis is inhibited by suppressing the expression of several transcription factors involved in differentiation into adipocytes.

The researchers from Osaka University showed how bone erosion caused by cholesteatoma occurs. This study showed that a subset of cells called osteoclastogenic fibroblasts expresses a protein, activin A, which causes the breakdown of the bones. Because of this discovery, novel medical treatments can be developed as first-line management for cholesteatomas.

Researchers from Osaka University found that patients with persistently high levels of urinary albumin excretion in the long term are at high risk of new-onset heart failure. Preventive treatment associated with the lowering of urinary albumin excretion levels in these patients could reduce the risk of later heart failure or mortality.

Researchers from Osaka University have demonstrated a proof-of-concept for identifying single nucleotides by using quantum computing. Molecular rotation patterns—and the corresponding variations in conductance—within the nanoscale gap between two electrodes enabled the development of a quantum gate for the nucleotide adenosine monophosphate. Developing quantum gates for the other three nucleotides, and incorporating this technology into DNA sequencing workflows, could revolutionize genome analysis.

Scientists have isolated potent neutralising antibodies from a COVID-19 vaccinated SARS survivor that exhibited remarkable breadth against known sarbecoviruses. The antibodies targeted a conserved region of the spike protein and blocked receptor binding and viral fusion. These findings could guide the development of broadly active therapeutics against current and future coronaviruses.