Medicine

ChatGPT’s diagnostic capabilities evaluated in comparison to radiologists

Pathogens hijack host cell functions by expressing or secreting effector proteins, creating environments conducive to their survival and reproduction. These pathogenic microorganisms—including eukaryotic parasites, prokaryotic bacteria, and viruses—express effector proteins that function as their "ammunition depot". These proteins are crucial for pathogen survival and dissemination, enhancing the efficiency of invasion, suppressing the host's immune system, or initiating pathogen replication. For instance, viruses may interfere with host signaling pathways, pushing cells into states that favor viral replication. Similarly, certain bacteria secrete toxins that disrupt the host cell cytoskeleton, facilitating pathogen invasion and spread. Additionally, pathogens can evade immune surveillance by suppressing the host's immune response, thereby increasing the likelihood of a successful infection.

A clinical trial conducted by Tohoku University researchers has lead to the approval of a treatment for patients with a rare, muscle-weakening disease called GNE myopathy.

Recent advances in medical science have complicated clinical decision-making, raising ethical issues. Hospitals have set up clinical ethics consultation systems, but their effectiveness is limited due to low awareness and communication difficulties. To address this, a research group initiated by Osaka University studied proactive ethics consultation practices, proposing strategies like “inter-professional ethics rounds" and "patient note reviews." These methods aim to resolve ethical issues, improve care, and alleviate moral dilemmas facing medical staff.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are the ‘holy grail’ of insulin treatments, a new species that ate like a walrus, and keeping cool in smart, adaptive clothing.

Cell–cell adhesion-induced patterning in keratinocytes can be explained by just starvation and strong adhesion, Hokkaido University researchers find.

- DGIST-Sungkyunkwan University research team successfully develops a next-generation bioelectronic suture that can monitor inflammation around wounds in real time - Maintains the functionality of traditional surgical sutures while monitoring inflammation... Expected to contribute to advances in wound care and related medical fields

Ecklonia cava, a brown algae seaweed, is shown to have the ability to protect against neurodegeneration

Growing use of AI reveals the need for global sustainability initiatives

Applied Microbiology International has announced that it has recruited 11 new Global Ambassadors from around the world.

A new treatment combining tiny iron particles and nitric oxide gas shows promise in targeting oral cancer cells for destruction.

Researchers develop method to calculate the probability of a fall for older adults

The anti-tumor drug indisulam has shown promise both in cell cultures and in animal studies. However, clinical trials have shown fewer clear-cut results. Scientists from Hiroshima University Hospital have been researching the reasons behind this resistance to it.

New scoring model enhances early prognosis prediction using prehospital resuscitation data only

Detailed analysis of bone density changes and stem-femur contact after total hip replacement

Researchers from Osaka University interviewed Japanese women using oral contraceptives (OC) in Korea, revealing clinical and ethical issues faced by transnational patients. The study identified new health care types and highlighted differing perceptions of OC between patients and doctors upon returning to Japan, creating dilemmas. Ethical implications were proposed, and future access to patient-centered medicine and drug reclassification was investigated to improve SRHR issues in Japan.

Combination of venetoclax and azacitidine helps patients with AML who relapse after hematopoietic cell transplant

A method to screen a wide variety of drug candidates without laborious purification steps could advance the fight against drug-resistant bacteria.

Researchers from Japan discover a new enzyme with promising antibacterial activity

Potential benefits of method include subjecting patients to fewer exams and reducing health care costs

Decoding dead stars’ “heartbeats”, Why do females live longer? DNA controller for molecular robots, Earliest twin quasars found. Read all in the latest Editor's Choice. Plus July's SciCom Coffee with A*STAR's Lisa Chong and get the early bird price to be in Asia Research News 2025.

Osaka University researchers developed molecules, called splice-switching oligonucleotides (SSOs) that bind to the RNA molecules encoding a protein known as REST. In neuroendocrine tumors, these RNAs are incorrectly spliced together, which supports the cancerous phenotype. When injected into tumors in laboratory mice, SSOs could help restore normal REST function, leading to reduced tumor size. This novel approach is a promising new tool for treating neuroendocrine tumors that do not respond to conventional therapies.

Results compare favorably with conventional microscopic method, with added benefit of shorter operative times, less blood loss

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are how to reach your 100th birthday, a (slightly unnerving) robot covered in human skin, and a feline urine test.

Researchers from Osaka University have identified that the loss of the Men1 gene is key in the development of osteoporosis, fragile bones occurring with age. They developed a mouse model of age-related cellular aging, or ‘senescence’, in the bone for the first time. This showed that cellular senescence of bone-forming osteoblasts leads to osteoporosis due to an imbalance between the activities of bone formation and bone resorption, opening avenues for drug intervention and novel treatments.

Researchers from Tohoku University and Kyoto University have succeeded in developing a DNA–based molecular controller. Crucially, this controller enables the autonomous assembly and disassembly of molecular robots, as opposed to manually directing it.

Researchers from Osaka University found that germ cells, which develop into eggs and sperm, drive sex-dependent differences in lifespan in vertebrates. Female and male germ cells increase and reduce lifespan, respectively. These effects are controlled via estrogen and growth factor hormones in females and vitamin D in males. Vitamin D supplementation extends lifespan in both males and females. The results clarify the link between reproduction and aging and show that vitamin D may improve longevity in vertebrates.

Blue energy future, Off switch for brain cells, New Japanese lily species, Generative AI in motion, Economies take off with new airports and Braille-shaped electrodes for retinal implants. Read all in the latest Editor's Choice. Plus SciCom Coffee with Catriona Child.

Osaka University researchers discovered a correlation between high GDF15 levels in steatotic liver patients and increased liver cancer risk. Steatotic liver disease cases, fueled by lifestyle-related issues, have surged globally, with Japan reporting a significant prevalence. Elevated GDF15 levels also signify complication risks associated with liver cirrhosis. Combining GDF15 levels and FIB-4 index aids efficient liver cancer detection, potentially improving prognosis through early intervention.

The largest graduating class in Duke-NUS’ history saw 90 graduates, including the first-ever Master of International Translational Medicine cohort, receive their degrees. Collectively, this cohort published 99 academic publications, underscoring Duke-NUS’ role as a leader in innovation and academic rigour in medical education. Celebrating diverse pathways to a career in healthcare, the graduates’ first degrees reflect diverse backgrounds, including architecture, communication studies and engineering, among others.