Medicine

Scientists identified a protein that regulates cellular clean-up, could also hold the key to new treatments for age-related muscle loss and muscle wasting in cancer patients, enhancing quality of life.

The Androgen Receptor in Mesenchymal Progenitor Cells Drives Skeletal Muscle Mass Regulation

By targeting multiprotein molecule, antibody inhibits bacteria’s growth, pathogenicity

• Two-year assessment provides critical insights and recommendations for strengthening genomic sequencing for infectious disease surveillance in 13 South and Southeast Asian countries. • Research helps to step up Asia’s preparedness across wide range of diseases.

Researchers from Osaka University studied the neurological control applied to human walking that maintains the correct relationship between the leg positions. They found that the rhythm of each leg continues independently unless they become too far out of phase. This work can lead to better care for people who have difficulty walking due to age or neurological issues.

A research team from Osaka University has discovered a novel mechanism essential for initiating autophagy. The study highlights the role of ZDHHC13, an enzyme that palmitoylates ULK1, in triggering autophagy. This discovery sheds light on the molecular pathways involved in autophagy and their implications for diseases such as cancer, neurodegenerative disorders, and aging-related conditions.

Incidence, risk factors found for pulmonary aspergillosis, an invasive fungal infection of lungs, among COVID-19 patients

An international consortium led by Duke-NUS Medical School introduces an ethics checklist for systematic and standardised assessment for research involving generative AI technologies in healthcare settings, enhancing accountability

Researchers from Osaka University found that antibiotic-resistant bacteria are fatter and shorter than their antibiotic-sensitive parental strains, and that these morphological changes correlate with changes in the expression of genes related to energy metabolism and antibiotic resistance. A machine learning approach was able to distinguish between antibiotic-resistant and antibiotic-sensitive bacteria in the absence of drug treatment based on microscope images, suggesting that bioinformatics could be used to detect antibiotic resistance in patient samples.

Learned society and publisher Applied Microbiology International (AMI) has announced a new partnership with science communicators SelectScience. The two organisations will be working together on SelectScience’s upcoming CLINICAL24 campaign and beyond.

A recent study from Osaka University reveals that intensive diabetes treatment can improve periodontal disease inflammation. Researchers found that two weeks of intensive diabetes treatment under hospitalization for patients with type 2 diabetes significantly improved not only blood sugar control but also PISA, an indicator of gum disease inflammation. Furthermore, the improvement in PISA was related to factors such as insulin secretion capacity and the severity of diabetes complications and comorbidities before diabetes treatment. These findings suggest that early intervention in diabetes is crucial for improving gum disease in diabetic patients.

Researchers from Osaka University found that T cells recognize neoself-antigens––abnormal, unfolded host proteins presented by major histocompatibility complex II (MHC-II) lacking the invariant chain––as non-self antigens, leading to the development of autoimmunity. Reactivation of Epstein–Barr virus, a known risk factor for lupus onset and exacerbation, increases the presentation of neoself-antigens by MHC-II, which could help explain the link between viral infection and autoimmune disease.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are a computer chip inspired by our brains, the potential link between asthma and diabetes, and how Japanese eels flee their predators after being swallowed.

A better understanding of how cells regulate their membranes could lead to new treatments for diseases such as epilepsy and anemia.

Researchers from Monash University and Osaka University find that administering regulatory T cells (Tregs) to a tissue injury can promote healing. The team locally treated mouse bone, muscle, and skin injuries with Tregs, resulting in significant tissue regeneration and wound healing compared with control treatments. Mechanistically, Tregs can promote tissue monocyte and macrophage switching to an anti-inflammatory state, specifically by secreting signaling molecules like interleukin-10. These data demonstrate the strong potential of using Tregs as a cell-based therapy for regenerative medicine.

Whether immunotherapy or conventional chemotherapy carries less mortality risk depends on BMI

Seaweed helps brain health, Whales in long-distance relationships, Jumpstarting male fertility, Demystifying black hole turbulence, Shrimp to steel & Mpox Resources. Read all in the latest Editor's Choice.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are how a live pig was operated on by a surgeon thousands of kilometers away, how an asteroid caused a massive ancient impact, and the day the sun grew dark 6,000 years ago.

Researchers from Osaka University have identified key immune cells that respond to the COVID-19 mRNA vaccination. These cells, known as activated atypical B cells, are increased in blood samples from people who have been vaccinated against COVID-19. Additionally, people with higher levels of these cells have more antibodies to fight the COVID-19 virus. These findings should help researchers assess how well people respond to the vaccine and help improve the design of new vaccines.

Suppression of an enzyme might allow melanocytes to recover

Studied oxidative stress and Parkinson’s disease as a case study

Feeder-free induced pluripotent stem cells hold hope in therapies for cats’ chronic kidney disease

Mpox has now been reported in Asia. Asia Research News has compiled a small selection of resources for better understanding.

ChatGPT’s diagnostic capabilities evaluated in comparison to radiologists

Pathogens hijack host cell functions by expressing or secreting effector proteins, creating environments conducive to their survival and reproduction. These pathogenic microorganisms—including eukaryotic parasites, prokaryotic bacteria, and viruses—express effector proteins that function as their "ammunition depot". These proteins are crucial for pathogen survival and dissemination, enhancing the efficiency of invasion, suppressing the host's immune system, or initiating pathogen replication. For instance, viruses may interfere with host signaling pathways, pushing cells into states that favor viral replication. Similarly, certain bacteria secrete toxins that disrupt the host cell cytoskeleton, facilitating pathogen invasion and spread. Additionally, pathogens can evade immune surveillance by suppressing the host's immune response, thereby increasing the likelihood of a successful infection.

A clinical trial conducted by Tohoku University researchers has lead to the approval of a treatment for patients with a rare, muscle-weakening disease called GNE myopathy.

Recent advances in medical science have complicated clinical decision-making, raising ethical issues. Hospitals have set up clinical ethics consultation systems, but their effectiveness is limited due to low awareness and communication difficulties. To address this, a research group initiated by Osaka University studied proactive ethics consultation practices, proposing strategies like “inter-professional ethics rounds" and "patient note reviews." These methods aim to resolve ethical issues, improve care, and alleviate moral dilemmas facing medical staff.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are the ‘holy grail’ of insulin treatments, a new species that ate like a walrus, and keeping cool in smart, adaptive clothing.

Cell–cell adhesion-induced patterning in keratinocytes can be explained by just starvation and strong adhesion, Hokkaido University researchers find.

- DGIST-Sungkyunkwan University research team successfully develops a next-generation bioelectronic suture that can monitor inflammation around wounds in real time - Maintains the functionality of traditional surgical sutures while monitoring inflammation... Expected to contribute to advances in wound care and related medical fields