Medicine

Researchers from The University of Osaka identify a molecule that can support specific therapeutic targeting of AML with chimeric antigen receptor therapy

The study conducted by Prof. Thai-Yen Ling at National Taiwan University underscores the potential of small extracellular vesicle (sEV) therapy and enhances the precision of acute liver failure treatment through the application of click chemistry.

The Ateneo Laboratory for Intelligent Visual Environments (ALIVE) found a way to identify tooth and sinus structures with an accuracy of 98.2%

Researchers develop innovative phospholipids that improve the functional delivery of mRNA via lipid nanoparticles, paving the way for advanced therapeutic applications.

The current capabilities of large language models already qualify them to advise students on medical ethics

A study shows apixaban lowers clot recurrence in dialysis patients post-thrombectomy, with minor bleeding risks.

Considerable positive results found in mice with skin condition induced by external factors

* "Survivors of SJS/TEN Face a Higher Risk of Cardiovascular Diseases and Death for Years After the Acute Phase" * "Tailored Strategies Needed for Early Detection, Prevention, and Intervention to Reduce Long-Term Cardiovascular Burdens in SJS/TEN Survivors"

Effective treatment of gastric cancer-bacterial infections begins with understanding differing clinical methods

A self-assessment questionnaire has been developed to evaluate on-the-job training progress

Gene mutations in acute myeloid leukemia (AML) cells can guide treatment options, and machine learning can rapidly guess the existence of gene mutations based on images of leukemia cells.

Cerebellar rhythm loss due to climbing fiber regression is a shared pathophysiology of motor deficits across cerebellar ataxias.

Researchers at National Taiwan University have unveiled an innovative diagnostic tool that significantly improves the speed and accuracy of detecting bacterial infections.

Researchers from Osaka University found that plasma cells expressing high levels of the protein integrin β7 and the transcription factor KLF2 tend to leave immune tissues and migrate to the bone marrow. There, they become long-lived plasma cells that help create durable antibody responses, which are key to vaccine effectiveness.

Researchers from Osaka University analyzed the clinical dental records of a large group of patients with hypophosphatasia (a skeletal disease) to identify its common oral symptoms. Their findings, including early tooth loss, poor oral habits, and disordered swallowing, may help early diagnosis of hypophosphatasia, thereby improving patient treatment and quality of life.

Concurrent steatotic liver disease (SLD) is prevalent among patients with chronic hepatitis B (CHB); however, the effects of the associated cardiometabolic risk factors on all-cause and cause-specific mortality remain unknown. This study demonstrated that cumulative metabolic burden dose- dependently increased the risks of all-cause, liver-related, and cardiovascular mortality in patients with CHB and SLD. Moreover, new-onset diabetes mellitus, hypertension, and weight gain during the follow-up period further exacerbated these risks. However, patients with SLD had a lower risk of mortality than those without SLD. Thus, routine screening and monitoring of metabolic dysfunctions constitute a key element of daily care for patients with CHB.

This study questions recent claims about the rapid effectiveness of psychedelic drugs for treating depression. Among all psychedelics, only high-dose psilocybin showed greater effectiveness than the placebo in antidepressant trials and outperformed escitalopram.

Glaucoma is called the “silent thief of sight” as many don’t notice until significant, irreversible vision loss has already occurred. A revolutionary early screening tool using AI may stop this thief dead in its tracks.

N-Cadherin is found to boost cardiomyocyte regeneration after injury by stabilizing β-Catenin, suggesting a potential new way to improve the function of human failing hearts.

The intersection of technology and psychological health has become a critical area of enquiry in interpersonal, workplace and organisational contexts in the digital era. With the support of the Guangdong-Hong Kong-Macao University Alliance, the Department of Psychology at Lingnan University in collaboration with Sun Yat-sen University and Renmin University hosted the inaugural International Conference and Workshop on Health and Well-being in the Digital Era on the Lingnan campus yesterday, 21 February. The conference continues today, 22 February, on Sun Yat-sen University’s Shenzhen campus. It highlights the crucial role of psychological science in shaping AI applications across work, healthcare, and daily life, and attracted about 160 participants on the first day.

Asteroid contains life’s building blocks, How fish detect color, Eco-friendly artificial muscles, Cell imaging gets a glow-up, Quantum gem, Healing skin with milkfish. Plus the 2025 Magazine is here, Read all in the latest Editor's Choice.

As populations age worldwide, diseases like pulmonary fibrosis are increasingly impacting life expectancy and quality. Duke-NUS researchers have identified that blocking specific proteins in immune cells can significantly reduce or reverse lung scarring. This discovery paves the way for novel treatments that could potentially reverse damage from pulmonary fibrosis.

Researchers from Osaka University found that peristaltic pump flow mechanically breaks supersaturation to induce amyloid formation by hen egg white lysozyme, α-synuclein, amyloid β 1-40, and β2-microglobulin. The high shear stresses induced by peristaltic flow likely reflect those that occur the blood and cerebrospinal fluid, suggesting that this factor could promote amyloidosis.

A bilayer alginate hydrogel system encapsulating polyelectrolyte complex nanoparticles (PCNs) loaded with anti-inflammatory cytokines and angiogenic growth factors, which reducing inflammation, stimulating angiogenesis, and accelerating wound closure in a diabetic murine model.

Today (12 February), in the second session of the “A Personal Perspective on Doing Good Research” seminar series organised by the School of Graduate Studies of Lingnan University, Prof Raymond Chan Hon-fu, Vice-President (Academics) cum Provost and Lam Man Tsan Chair Professor of Scientific Computing at Lingnan University, gave a talk entitled “Research Methodology—A Computational Mathematician’s Perspective”, attended by about 100 teachers and students.

A team from Osaka University has developed scSPOT, a new technique that reveals how immune cells called Tregs simultaneously control the immune system. The team identified key immune cells controlled by Tregs and found that Tregs are targets for the cancer drugs ipilimumab and tazemetostat. They also found that Tregs are indicators of serious viral infection. This valuable technique may accelerate the development of treatments for cancer and other diseases.

Researchers from Japan find that certain antioxidant enzymes, called selenoproteins, significantly contribute to fighting cell aging. The team used a gene knockout mouse model to help them study the effects of disrupting selenoprotein synthesis. This knockout negatively impacted hematopoietic stem cells and B cell-lineage immune cells, which was driven by the lack of selenoprotein-mediated fighting of lipid peroxides. These phenotypes mimic what is observed in age-related diseases, emphasizing the importance of selenoproteins in these disorders.

Latest findings on the significance and interaction between cell death and cellular senescence in cancer

Gel-based sample pre-fractionation leads to detailed proteoform analysis with mass spectrometry

At Duke-NUS Medical School scientists are pioneering breakthroughs in precision medicine and regenerative therapies, targeting everything from muscle loss to dramatically extending our years of health.