Medicine
News
05 Aug 2022
Scientists at Duke-NUS Medical School, Singapore, have found that elevated blood levels of an amino acid called homocysteine correlate strongly with the severity of an advanced form of non-alcoholic fatty liver disease. They also found vitamin B12 and folic acid could potentially prevent and/or delay disease progression.
03 Aug 2022
Researchers have discovered that vitamin K acts as a powerful antioxidant. It can inhibit ferroptosis, a type of cell death associated with Alzheimer’s disease and organ damage, by trapping lipid radicals. Furthermore, the team identified the long-sought-after vitamin K-reducing enzyme, the identity of which remained unknown for more than half a century.
31 Jul 2022
The history of extracting chay root dye — a natural red colourant — from the chay plant (Oldenlandia umbellata) dates back to at least the seventeenth century. Read on to know more about the relevance of the dye in the textile dyeing practices of southern India.
29 Jul 2022
Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are the discovery of an ancient palace that could be connected to Genghis Khan, the joy of letting your mind wander, and a wound dressing made from frog skin that promotes healing.
23 Jul 2022
Researchers create 'time machine' to study ancestor galaxies, Robotics engineers pay attention to matters of the heart, Custom suits for delivery worms, Tough, light structures with superior impact resistance and Virtual training can reduce stress and anxiety. Read all in the July's Editor's Choice plus op-ed: To boost South Korea’s basic science, look to values, not just budgets, this month's Image & Asia Research News 2022 magazine pick - Better memristors for brain-like computing.
22 Jul 2022
The World Health Organization (WHO) welcomes the launch by Gavi, the Vaccine Alliance, of the landmark opportunity for countries to apply for funding to introduce, or further roll-out, the RTS,S/AS01 (RTS,S) malaria vaccine.
22 Jul 2022
Osaka University researchers designed a silicon-based agent that successfully generated hydrogen continuously in the mouse gastrointestinal tract in an ulcerative colitis (UC) model. The hydrogen served as an antioxidant that could eliminate the reactive oxygen species shown to induce the chronic inflammation responsible for the damage and symptoms caused by UC. Mice given the agent had reduced hemorrhage, inflammation, and hyperexcitability in the brain area associated with visceral pain and discomfort. These results may help with the development of a novel treatment for UC.
15 Jul 2022
Cultured human skeletal muscle cells infused with serum from hibernating bears exhibited “muscle gain” confirming that these creatures’ ability to avoid muscular damage despite months of inactivity is in their blood.
05 Jul 2022
23 Gold awarded at MTE 2022: COVID-19 International Innovation Awards and Advanced Healthcare & Life Sciences International Innovation Awards
02 Jul 2022
An artificial intelligence (AI) algorithm trained to listen to patients pass urine is able to identify abnormal flows and could be a useful and cost-effective means of monitoring and managing urology patients at home. It is presented today at the European Association of Urology annual congress (EAU22), in Amsterdam.
01 Jul 2022
Specialised physician training, nurse-led motivational conversations and follow-up with patients, and subsidy on combination medication significantly lowered BP among patients with uncontrolled hypertension, according to findings from Singapore.
28 Jun 2022
Chula Engineering and Chula Medicine co-invent an innovative device for a rapid and accurate gastrointestinal cancer detection hoping to foster preventive medicine and reduce the number of cancer patients.
27 Jun 2022
Researchers from Osaka University have found that infection with SARS-CoV-2 activates the expression of IRF1, a key regulator of insulin/IGF signaling in multiple tissues, leading to disruption of blood sugar metabolism and, in some cases, new onset of diabetes. Treating infected cells with hormonal factors that decreased IRF1 expression enhanced insulin/IGF signaling, suggesting that this approach could be used to mitigate some of the more severe side effects of COVID-19 in the future.
24 Jun 2022
Automation in disease diagnosis is reliant on deep learning models that can accurately and efficiently identify measurements of tumors, tissue volume, or other sorts of abnormalities. Now, researchers from Tohoku University have unveiled a new, resource-light model capable of identifying many common eye diseases.
23 Jun 2022
Researchers from Osaka University have found that nematodes can be coated with a protective hydrogel sheath that can be engineered to carry functional cargo. This system could potentially be developed to deliver anti-cancer drugs to tumors using worms with a natural predilection for human cancer cells.
22 Jun 2022
New dinosaur species used claws to graze along the coast, More accurate rainfall predictions, Magnetism helps futuristic cell research, Do compression garments facilitate muscle recovery? Science journalism and why it matters for democracy and our Image of the month. Read all in the June's Editor's Choice and this month's Asia Research News 2022 magazine pick - Lessons from the dead.
21 Jun 2022
• The Satellite Center at Duke-NUS marks the latest achievement for the SingHealth Duke-NUS Academic Medical Centre’s vision for a Discovery District on its Campus.
• It is also the first Asia Pacific site in Johnson & Johnson’s network of research collaborations aimed at addressing endemic and emerging pandemic threats.
20 Jun 2022
Researchers in Japan outline preliminary research that could pave the way for a future test to diagnose ALS, a progressive disease of the nervous system.
11 Jun 2022
Duke-NUS is working with the Bill and Melinda Gates Foundation to develop the Asia Pathogen Genomics Initiative (APGI) to improve regional genomic surveillance and sequencing capacity. New Centre for Outbreak Preparedness will support APGI and work closely with national and global partners to enhance regional capacity to predict, prepare and respond to future health threats.
10 Jun 2022
SINGAPORE, June 9, 2022– Takeda Pharmaceutical Company Limited (“Takeda”) today announced that its dengue vaccine candidate, TAK-003, prevented 61% of symptomatic dengue cases and 84% of hospitalised cases with no important safety risks identified in the overall population.
07 Jun 2022
Potential of a novel therapeutic strategy for rheumatoid arthritis by UHRF1 stabilization
We identified an epigenetic regulator UHRF1 that suppresses various pathogeneses in rheumatoid arthritis. The UHRF1 expression level in synovium showed a negative correlation with the severity of pathogenesis in patients with rheumatoid arthritis and mouse arthritis models. In addition, stabilization of the UHRF1 expression achieved improvement of the arthritis pathology. Our results indicate that the stabilization of the UHRF1 protein is a potential therapeutic strategy for rheumatoid arthritis patients.
02 Jun 2022
Giants in History: Known for her pioneering contributions to bio-organic chemistry, Darshan Ranganathan (4 June 1941 – 4 June 2001) is considered India’s most prolific chemist.
01 Jun 2022
Scientists at Osaka Metropolitan University utilized a Japan-developed, objective, and simple nutritional indicator called the Nutrition Risk Index (NRI) to unveil a long-suspected yet unverified relationship between sarcopenia and malnutrition in end-stage kidney disease patients. Their findings confirmed that malnutrition contributes to sarcopenia, which can be detected through NRI.
30 May 2022
A research team led by Hong Kong Baptist University (HKBU) has found that a proteolytic enzyme called membrane-type 1 matrix metalloproteinase (MT1-MMP) plays an important role in the regulatory mechanism of fullness, or satiety, and it could serve as a promising potential drug target for the management of obesity.
25 May 2022
Among anesthetics, ketamine has a unique effect: it also acts as an antidepressant. A research team led by Osaka Metropolitan University Professor Makoto Kondo linked ketamine to brain regulation of IGF-1, which works independently of other ketamine-associated factors. The discovery may help untangle ketamine’s positive and negative effects, allowing future drug development to target IGF-1 directly.
23 May 2022
The antibiotic rifampicin is shown as a potential medicine for preventing Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal dementia (FTD).
19 May 2022
Thought to enhance muscle recovery, compression garments are commonly worn by athletes and people engaging in exercise. Yet, an international research team’s systematic review provides evidence to the contrary.
13 May 2022
Molecular robots work cooperatively in swarms, LED lights made from rice husk, Muonic x-rays safely see inside samples, Making a luminescent material shine brighter and How to counter vaccine hesitancy, Read all in the May Editor's Choice and this month's Asia Research News 2022 magazine pick - Absorbing impact: Inside the Head of a Woodpecker.
27 Apr 2022
A new report by the InterAcademy Partnership (IAP) highlights practical recommendations for improving the uptake of vaccines.
25 Apr 2022
Examination of endangered species’ stem cells unveils ancient genetic links between mammals.
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Giants in history
Henriette Bui Quang Chieu (1906 – 2012) was inspired to follow in her brother’s footsteps and become a doctor after losing her mother to tuberculosis. She studied in France and became the first Vietnamese woman to receive a medical degree. Upon her return to Vietnam, Bui was appointed head of the Department of Midwifery at Cho Lon Hospital in Ho Chi Minh City. A pioneer in gynaecology, she applied acupuncture techniques that she had learned in Japan to obstetrics. As Vietnam was still a French colony, Bui also lobbied for the rights of Vietnamese doctors, nurses, and patients.
Japanese biochemist Akira Endo (1933 – 2024) discovered the first statin, called mevastatin, which lowered cholesterol levels in the blood by inhibiting a key enzyme in the cholesterol biosynthesis pathway. His work laid the foundation for the development of statins to help patients lower their blood cholesterol levels and reduce their risk of heart disease or stroke.
Filipina paediatrician and scientist Perla Santos-Ocampo (25 July 1931 – 29 June 2012) made important contributions to treatments and policies that curbed debilitating and sometimes deadly diarrhoea-related diseases and malnutrition in children.
Singaporean physician Oon Chiew Seng (1916 – 31 March 2022) advanced dementia care and research in Singapore, and co-founded the Apex Harmony Lodge, the nation’s first nursing home for residents with dementia.
Vietnamese surgeon Tôn Thất Tùng (10 May 1912 – 7 May 1982) developed a pioneering technique that reduced the risks and mortality rate of liver operations.
Michiaki Takahashi (17 February 1928 – 16 December 2013) was a Japanese virologist who developed the first chickenpox vaccine.
Irene Ayako Uchida’s (8 April 1917 – 30 July 2013) strides to understand genetic diseases such as Down syndrome paved the way for early screening of chromosomal abnormalities in foetuses.
Baron Kitasato Shibasaburo (29 January 1856 – 13 June 1931) was a Japanese physician and bacteriologist whose work led to a new understanding of preventing and treating tetanus, diphtheria and anthrax.
Maggie Lim (5 January 1913 – November 1995) was a Singaporean physician who promoted family planning and expanded the access to clinics to improve the quality of life for mothers and children in Singapore’s early days.
By isolating soil microorganisms and studying the compounds they produce, Satoshi Omura (born 1935) discovered almost 500 organic compounds with unique properties that were produced by these microorganisms, including many new antibiotics.
The founder of the Adyar Cancer Institute in India, Muthulakshmi Reddy (30 July 1886 – 22 July 1968), fought to uplift women and girls from impoverished situations.
Chinese-American virologist and molecular biologist Flossie Wong-Staal (27 August 1946 – 8 July 2020) was the first scientist to clone HIV and determine the function of its genes.
Maharani Chakravorty (1937 – 2015) was one of India’s earliest molecular biologists whose research paved the way for advances in the treatment of bacterial and viral infections.
Archana Sharma (16 February 1932 - 14 January 2008) conducted research into plant and human genetics that expanded the understanding of both botany and human health. In relation to botany, she uncovered the means by which asexually-reproducing plants evolve into new species.
The first Thai woman to receive a degree in medicine, Margaret Lin Xavier (29 May 1898 – 6 December 1932), is best remembered for her compassion towards her less privileged patients.
In 1915, pathologist Katsusaburo Yamagiwa and his research assistant Koichi Ichikawa became the first to prove that chronic exposure to chemicals can cause cancer.
In 1915, Koichi Ichikawa along with pathologist Katsusaburo Yamagiwa became the first to prove that chronic exposure to chemicals can cause cancer.
Husband and wife team, Kimishige (3 December 1925 – 6 July 2018) and Teruko Ishizaka (28 September 1926 – 4 June 2019) discovered the antibody class Immunoglobulin E (IgE) that triggers allergic reactions. They also discovered that IgE antibodies attach to white blood cells, known as mast cells, releasing histamine, which causes allergic reactions.
Husband and wife team, Kimishige (3 December 1925 – 6 July 2018) and Teruko Ishizaka (28 September 1926 – 4 June 2019) discovered the antibody class Immunoglobulin E (IgE) that triggers allergic reactions. They also discovered that IgE antibodies attach to white blood cells, known as mast cells, releasing histamine, which causes allergic reactions.
Japanese chemist Takamine Jokichi (3 November 1854 – 22 July 1922) founded the Tokyo Artificial Fertilizer Company, where he isolated a starch-digesting enzyme (named takadiastase) from the fungus Aspergillus oryzae.
Ground-breaking cancer researcher Kamal Jayasing Ranadive (8 November 1917 – 11 April 2001) advanced the understanding of the causes of leukaemia, breast cancer and oesophageal cancer through the use of animal models. She was also among the first to recognise how susceptibility to cancer is linked to tumour-causing interactions between hormones and viruses.
The research of Filipino pharmaceutical chemist Luz Oliveros-Belardo (3 November 1906 – 12 December 1999) focussed on essential oils and other chemicals derived from native Philippine plants.
Thai physician and conservationist Boonsong Lekagul (1907 – 1992) made major contributions to the preservation of his country’s wildlife.
Indian scientist and physician Upendranath Brahmachari (19 December 1873–6 February 1946) is best known for creating a drug called Urea Stibamine, used to safely and reliably treat visceral leishmaniasis (or Kala-azar), a severe infection caused by the Leishmania parasite.
Filipino chemist and pharmacist Manuel A. Zamora (29 March 1870 – 9 July 1929) is best remembered for his discovery of the tiki-tiki formula to combat beriberi, a disease caused by Vitamin B1 deficiency.
Korean parasitologist Seung-Yull Cho (16 November 1943 – 27 January 2019) is remembered largely for his pioneering works to control infections caused by helminthic parasites and his contribution to journal publishing.
Fe Villanueva del Mundo (27 November 1911 – 6 August 2011) was a Filipina paediatrician who founded the Philippines’ first paediatric hospital.
After witnessing death and suffering as a youth in his home village during World War II, Nguyễn Tài Thu (6 April 1931 – 14 February 2021) set his sights on alleviating pain by becoming a doctor. After studying Traditional Chinese Medicine in China in the 1950s, Thu returned to Vietnam to serve in military hospitals. Eventually, he became the country’s foremost practitioner of acupuncture, a technique he first learned by inserting needles into himself.
Minoru Shirota (April 23, 1899 – March 10, 1982) was a Japanese microbiologist who invented the popular fermented drink Yakult.
Wu Lien-teh (10 March 1879 – 21 January 1960) was a Malaysian-born doctor who invented a mask that effectively suppressed disease transmission. Winning the prestigious Queen’s Scholarship enabled Wu to become the first Chinese student to study medicine at the University of Cambridge.
David T. Wong (born 1936) is a Hong Kong-born American neuroscientist who is best known for discovering the antidepressant drug fluoxetine, better known as Prozac.
Indian organic chemist Asima Chatterjee (1917 to 2006) studied the medicinal properties of plant products, especially compounds known as vinca alkaloids.
Tu Youyou (born 30 December 1930) is a Chinese pharmaceutical scientist who was awarded the 2015 Nobel Prize in Physiology or Medicine for her work on extracting artemisin from sweet wormwood to treat malaria.
Chika Kuroda (24 March 1884 – 8 November 1968) was a Japanese chemist whose research focussed on the structures of natural pigments.
Umetaro Suzuki (7 April 1874 – 20 September 1943) was a Japanese scientist best remembered for his research on beriberi, a disease caused by vitamin B1 deficiency, characterized by limb stiffness, paralysis and pain.
Salimuzzaman Siddiqui (19 October 1897 – 14 April 1994) was an artist and chemist from Pakistan whose research focused on natural products from plants.
Barry Paw (29 August 1962 – 28 December 2017) was a biologist and oncologist who discovered several novel genes and their functions in red blood cells.
Syed Qasim Mehdi (13 February 1941 – 28 September 2016) was a Pakistani molecular biologist who was a founding member of the Human Genome Diversity Project (HGDP), which assessed human diversity by studying human migration, mutation rates, relationships between different populations, genes involved in height and selective pressure.
Tsai-Fan Yu (1911 – 2 March 2007) was a Chinese-American physician and researcher who was the first female full professor at Mount Sinai School of Medicine. She discovered that gout, a condition characterized by the painful inflammation of joints, was caused by elevated levels of uric acid in the bloodstream.
Min Chueh Chang (10 October 1908 – 5 June 1991) was a Chinese-American biologist who studied fertilization in mammalian reproduction.
A Japanese surgeon, Tetsuzo Akutsu (20 August 1922 – 9 August 2007) built the first artificial heart capable of keeping an animal alive.
Ogino Ginko (3 March 1851 – 23 June 1913) was the first registered female doctor to practise modern medicine in Japan.
Esther Park (1877-1910), born Kim Jeom-dong, was the first female Korean physician to practise modern medicine in Korea and trained the first generation of Korean female doctors.