Medicine
News
04 Dec 2023
Tohoku University
Pregnancy brings a rise in pancreatic beta cells – the cells that produce insulin. Shortly after birth, these cells return to their normal levels. The mechanisms behind this process had remained a mystery. But now a research group has revealed that white blood cells called macrophages ‘eat’ these cells.
04 Dec 2023
Tohoku University
Decreasing pancreatic beta cell numbers – the only cells that produce insulin – is a leading cause of diabetes. In a promising development, a research group has revealed that stimulating autonomic vagal nerves connected to the pancreas can improve the function and also increase the number of pancreatic beta cells in mice.
28 Nov 2023
Osaka Metropolitan University
A research team from Osaka Metropolitan University has successfully developed a novel pneumococcal vaccine by combining the team’s proprietary mucosal vaccine technology with pneumococcal surface proteins that can cover a wide range of serotypes. Experiments were conducted using mice and macaques and it was confirmed that pneumonia caused by pneumococcal infection was clearly suppressed in the target groups of animals inoculated with the vaccine.
27 Nov 2023
The University of Osaka
Researchers from Osaka University found that HSP47, a collagen-specific chaperone, is a key determinant of body fat levels. HSP47 expression levels are upregulated with obesity and greater food intake and decreased with fasting, exercise, calorie restriction, bariatric surgery, and wasting syndrome, suggesting that HSP47 modulation has a profound effect on fat storage.
21 Nov 2023
The University of Osaka
Researchers from Osaka University have shown that lysosomes, key organelles for maintaining cellular stability, can be repaired once damaged by a process termed microautophagy. They identified molecules called STK38 and GABARAPs as key regulators of this process. Depletion of microautophagy regulators lead to increased cellular senescence and a shorter lifespan, indicating the importance of this process. This study is highly significant for the achievement of healthy aging and points toward new therapies for age-related diseases.
20 Nov 2023
National Institute for Materials Science (NIMS)
A new technique allows researchers to map how the cellular ‘skeleton’ adapts to external stress.
17 Nov 2023
Ehime University
Rapid preparation and application of a panel of clinical antibodies armed with B-BiTE for refractory malignancies
14 Nov 2023
Hokkaido University
Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors.
13 Nov 2023
Duke-NUS Medical School
New study finds prior dengue antibodies substantially raise risk of microcephaly, foetal defects with Zika infection.
13 Nov 2023
Osaka Metropolitan University
New insights on how individual immune responses to the SARS-CoV-2 virus, particularly in mutant strains, can influence the efficacy of COVID-19 vaccines
09 Nov 2023
Hong Kong Baptist University (HKBU)
The School of Chinese Medicine at Hong Kong Baptist University (HKBU) found that 55% of the patients who sought medical treatment from the “HKBU Chinese Medicine Telemedicine Centre Against COVID-19” during the fifth wave of the COVID-19 pandemic continued to experience at least one long COVID symptom for six months to a year after diagnosed with an infection. The most common symptoms are fatigue, brain fog and cough.
09 Nov 2023
Hong Kong Baptist University (HKBU)
A research led by Hong Kong Baptist University (HKBU) has discovered that hyodeoxycholic acid (HDCA), a bile acid generated in human intestine, can reduce fat accumulation and inflammation in the liver, demonstrating its strong therapeutic potential for non-alcoholic fatty liver disease (NAFLD). The research also found that HDCA’s intervention in NAFLD works by reshaping the population of beneficial gut bacteria, which affects the metabolic interactions between the gut and the liver. The result highlighted the critical role of gut health in liver disease.
09 Nov 2023
Asia Research News
New shrimp species in ancient hot spring, Super sprouts, How "warm-ups" work, New antiviral candidate, Solving voltage decay and from our blog: A sustainable future shines in TIE 2023. Read all in the latest Editor's Choice.
26 Oct 2023
The University of Osaka
Research from Osaka University demonstrates a nanopore-based technique that can detect different variants of SARS-CoV-2, the virus that causes COVID-19. The method was very effective in detecting the Omicron variant of the virus in the saliva of people with COVID-19.
26 Oct 2023
The University of Osaka
Research out of Osaka University finds an overlap in the mechanism of hair color determination and bone resorption, which is associated with bone related diseases like osteoporosis. The findings revealed that proteins named Rab32 and Rab38 play pivotal roles in bone resorption in osteoclast, cell specialized in the process. These proteins are also crucial for pigmentation of hair and skins.
24 Oct 2023
The University of Osaka
Research out of Osaka University investigated the effect of increased cell temperature on the contractility of skeletal muscle and cardiac muscle by heating the muscle proteins using advanced microscopical techniques. The findings indicated that skeletal muscle is more sensitive to increases in temperature than cardiac muscle, and that heating can rapidly activate the contractile proteins of skeletal muscle, thereby improving muscle performance.
20 Oct 2023
Hokkaido University
A broad-spectrum antiviral drug candidate, 2-thiouridine, that targets positive-strand RNA viruses has been identified and characterized.
20 Oct 2023
Duke-NUS Medical School
New perspective argues pursuing fair AI for healthcare requires cross-disciplinary collaboration to translate methods into real-world benefits.
16 Oct 2023
The shortlist for the Applied Microbiology International Awards 2023 has now been announced.
The AMI Awards programme is designed to celebrate the brightest minds in our field and promote the research, group, projects, products and individuals who continue to help shape the future of applied microbiology.
16 Oct 2023
The University of Osaka
Researchers from Osaka University developed a cell-friendly means of bioprinting at high fidelity. By successive injection of a cell-based ink and a printing support, the ink solidified into defined geometries, even into the shape of a human nose. Printed cells remained viable for at least two weeks. This work is an important milestone toward developing lab-grown tissues and organs, and eventually advancing regenerative medicine as well as animal-free drug safety testing.
06 Oct 2023
Osaka Metropolitan University
Osaka Metropolitan University researchers have used the power of laser light to accelerate the reaction between cancer cell-derived extracellular vesicles—a kind of nanoparticle—and antibody-modified microparticles. The three-dimensional structure of the resulting aggregates was then analyzed using a confocal optical system. The results demonstrated the ability to measure, within 5 minutes, approximately 1,000 to 10,000 nanoscale EVs contained in a 500 nL sample.
05 Oct 2023
Asia Research News
Hunting for supermassive black holes, Coastal survival at risk, Calcium and dead cell clean-up, Two naps are better than one & Pineapple leaf prosthetics. Read all in the latest Editor's Choice.
02 Oct 2023
The University of Osaka
The authors discovered a shorter isoform of Rubicon called RUBCN100, which enhances autophagy in B cells.
02 Oct 2023
The University of Osaka
The authors identified a structure in the circadian mRNA Period2 that affects the sleep-wake cycle. The results indicate how translation and post-transcriptional processes influence the body’s internal clock and its impact on sleep patterns.
15 Sep 2023
Hiroshima University
A reanalysis of studies on night shift naps reveals the ideal snoozing schedule that may help combat fatigue and drowsiness when staying up all night.
15 Sep 2023
The University of Osaka
Researchers led by Osaka University developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of enzyme that makes single-stranded “nicks” in the DNA. Repair of these nicks is more efficient and accurate than repair of double-strand breaks caused by the current CRISPR/Cas9 editing. This technique represents a novel approach for the treatment of genetic diseases caused by heterozygous mutations.
15 Sep 2023
Asia Research News
Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are a previously unrecorded species of ant found in someone’s backyard, comparing traditional medicine to drugs for indigestion, and how breastfeeding can help babies develop a healthy gut.
15 Sep 2023
Daegu Gyeongbuk Institute of Science and Technology (DGIST)
This novel technology:
- provides potential treatment in relation to restoring aging muscle cells obtained from older adults and remedying sarcopenia in aging animals through bioelectric medicine
- presents a new paradigm for treating sarcopenia, for which no drugs are currently available to treat this condition
- has been reported in the internationally renowned academic journal, Proceedings of the National Academy of Sciences (PNAS)
14 Sep 2023
Institute for Integrated Cell-Material Sciences (iCeMS) at Kyoto University
Scientists have found that extracellular calcium mediates the activation of a membrane protein that waves the flag signalling cell death
12 Sep 2023
Hiroshima University
AXL and EGFR inhibitors combined hold promise in fighting certain head, neck, and lung cancers
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Giants in history
Henriette Bui Quang Chieu (1906 – 2012) was inspired to follow in her brother’s footsteps and become a doctor after losing her mother to tuberculosis. She studied in France and became the first Vietnamese woman to receive a medical degree. Upon her return to Vietnam, Bui was appointed head of the Department of Midwifery at Cho Lon Hospital in Ho Chi Minh City. A pioneer in gynaecology, she applied acupuncture techniques that she had learned in Japan to obstetrics. As Vietnam was still a French colony, Bui also lobbied for the rights of Vietnamese doctors, nurses, and patients.
Japanese biochemist Akira Endo (1933 – 2024) discovered the first statin, called mevastatin, which lowered cholesterol levels in the blood by inhibiting a key enzyme in the cholesterol biosynthesis pathway. His work laid the foundation for the development of statins to help patients lower their blood cholesterol levels and reduce their risk of heart disease or stroke.
Tu Youyou (born 30 December 1930) is a Chinese pharmaceutical scientist who was awarded the 2015 Nobel Prize in Physiology or Medicine for her work on extracting artemisin from sweet wormwood to treat malaria.
Filipina paediatrician and scientist Perla Santos-Ocampo (25 July 1931 – 29 June 2012) made important contributions to treatments and policies that curbed debilitating and sometimes deadly diarrhoea-related diseases and malnutrition in children.
Singaporean physician Oon Chiew Seng (1916 – 31 March 2022) advanced dementia care and research in Singapore, and co-founded the Apex Harmony Lodge, the nation’s first nursing home for residents with dementia.
Vietnamese surgeon Tôn Thất Tùng (10 May 1912 – 7 May 1982) developed a pioneering technique that reduced the risks and mortality rate of liver operations.
Michiaki Takahashi (17 February 1928 – 16 December 2013) was a Japanese virologist who developed the first chickenpox vaccine.
Irene Ayako Uchida’s (8 April 1917 – 30 July 2013) strides to understand genetic diseases such as Down syndrome paved the way for early screening of chromosomal abnormalities in foetuses.
Baron Kitasato Shibasaburo (29 January 1856 – 13 June 1931) was a Japanese physician and bacteriologist whose work led to a new understanding of preventing and treating tetanus, diphtheria and anthrax.
Maggie Lim (5 January 1913 – November 1995) was a Singaporean physician who promoted family planning and expanded the access to clinics to improve the quality of life for mothers and children in Singapore’s early days.
By isolating soil microorganisms and studying the compounds they produce, Satoshi Omura (born 1935) discovered almost 500 organic compounds with unique properties that were produced by these microorganisms, including many new antibiotics.
The founder of the Adyar Cancer Institute in India, Muthulakshmi Reddy (30 July 1886 – 22 July 1968), fought to uplift women and girls from impoverished situations.
Chinese-American virologist and molecular biologist Flossie Wong-Staal (27 August 1946 – 8 July 2020) was the first scientist to clone HIV and determine the function of its genes.
Maharani Chakravorty (1937 – 2015) was one of India’s earliest molecular biologists whose research paved the way for advances in the treatment of bacterial and viral infections.
Archana Sharma (16 February 1932 - 14 January 2008) conducted research into plant and human genetics that expanded the understanding of both botany and human health. In relation to botany, she uncovered the means by which asexually-reproducing plants evolve into new species.
The first Thai woman to receive a degree in medicine, Margaret Lin Xavier (29 May 1898 – 6 December 1932), is best remembered for her compassion towards her less privileged patients.
Husband and wife team, Kimishige (3 December 1925 – 6 July 2018) and Teruko Ishizaka (28 September 1926 – 4 June 2019) discovered the antibody class Immunoglobulin E (IgE) that triggers allergic reactions. They also discovered that IgE antibodies attach to white blood cells, known as mast cells, releasing histamine, which causes allergic reactions.
Husband and wife team, Kimishige (3 December 1925 – 6 July 2018) and Teruko Ishizaka (28 September 1926 – 4 June 2019) discovered the antibody class Immunoglobulin E (IgE) that triggers allergic reactions. They also discovered that IgE antibodies attach to white blood cells, known as mast cells, releasing histamine, which causes allergic reactions.
In 1915, Koichi Ichikawa along with pathologist Katsusaburo Yamagiwa became the first to prove that chronic exposure to chemicals can cause cancer.
In 1915, pathologist Katsusaburo Yamagiwa and his research assistant Koichi Ichikawa became the first to prove that chronic exposure to chemicals can cause cancer.
Ogino Ginko (3 March 1851 – 23 June 1913) was the first registered female doctor to practise modern medicine in Japan.
Syed Qasim Mehdi (13 February 1941 – 28 September 2016) was a Pakistani molecular biologist who was a founding member of the Human Genome Diversity Project (HGDP), which assessed human diversity by studying human migration, mutation rates, relationships between different populations, genes involved in height and selective pressure.
Salimuzzaman Siddiqui (19 October 1897 – 14 April 1994) was an artist and chemist from Pakistan whose research focused on natural products from plants.
Umetaro Suzuki (7 April 1874 – 20 September 1943) was a Japanese scientist best remembered for his research on beriberi, a disease caused by vitamin B1 deficiency, characterized by limb stiffness, paralysis and pain.
Barry Paw (29 August 1962 – 28 December 2017) was a biologist and oncologist who discovered several novel genes and their functions in red blood cells.
Chika Kuroda (24 March 1884 – 8 November 1968) was a Japanese chemist whose research focussed on the structures of natural pigments.
Indian organic chemist Asima Chatterjee (1917 to 2006) studied the medicinal properties of plant products, especially compounds known as vinca alkaloids.
David T. Wong (born 1936) is a Hong Kong-born American neuroscientist who is best known for discovering the antidepressant drug fluoxetine, better known as Prozac.
Wu Lien-teh (10 March 1879 – 21 January 1960) was a Malaysian-born doctor who invented a mask that effectively suppressed disease transmission. Winning the prestigious Queen’s Scholarship enabled Wu to become the first Chinese student to study medicine at the University of Cambridge.
Minoru Shirota (April 23, 1899 – March 10, 1982) was a Japanese microbiologist who invented the popular fermented drink Yakult.
After witnessing death and suffering as a youth in his home village during World War II, Nguyễn Tài Thu (6 April 1931 – 14 February 2021) set his sights on alleviating pain by becoming a doctor. After studying Traditional Chinese Medicine in China in the 1950s, Thu returned to Vietnam to serve in military hospitals. Eventually, he became the country’s foremost practitioner of acupuncture, a technique he first learned by inserting needles into himself.
Fe Villanueva del Mundo (27 November 1911 – 6 August 2011) was a Filipina paediatrician who founded the Philippines’ first paediatric hospital.
Korean parasitologist Seung-Yull Cho (16 November 1943 – 27 January 2019) is remembered largely for his pioneering works to control infections caused by helminthic parasites and his contribution to journal publishing.
Filipino chemist and pharmacist Manuel A. Zamora (29 March 1870 – 9 July 1929) is best remembered for his discovery of the tiki-tiki formula to combat beriberi, a disease caused by Vitamin B1 deficiency.
Indian scientist and physician Upendranath Brahmachari (19 December 1873–6 February 1946) is best known for creating a drug called Urea Stibamine, used to safely and reliably treat visceral leishmaniasis (or Kala-azar), a severe infection caused by the Leishmania parasite.
Thai physician and conservationist Boonsong Lekagul (1907 – 1992) made major contributions to the preservation of his country’s wildlife.
The research of Filipino pharmaceutical chemist Luz Oliveros-Belardo (3 November 1906 – 12 December 1999) focussed on essential oils and other chemicals derived from native Philippine plants.
Ground-breaking cancer researcher Kamal Jayasing Ranadive (8 November 1917 – 11 April 2001) advanced the understanding of the causes of leukaemia, breast cancer and oesophageal cancer through the use of animal models. She was also among the first to recognise how susceptibility to cancer is linked to tumour-causing interactions between hormones and viruses.
Japanese chemist Takamine Jokichi (3 November 1854 – 22 July 1922) founded the Tokyo Artificial Fertilizer Company, where he isolated a starch-digesting enzyme (named takadiastase) from the fungus Aspergillus oryzae.
Tsai-Fan Yu (1911 – 2 March 2007) was a Chinese-American physician and researcher who was the first female full professor at Mount Sinai School of Medicine. She discovered that gout, a condition characterized by the painful inflammation of joints, was caused by elevated levels of uric acid in the bloodstream.
A Japanese surgeon, Tetsuzo Akutsu (20 August 1922 – 9 August 2007) built the first artificial heart capable of keeping an animal alive.
Min Chueh Chang (10 October 1908 – 5 June 1991) was a Chinese-American biologist who studied fertilization in mammalian reproduction.
Esther Park (1877-1910), born Kim Jeom-dong, was the first female Korean physician to practise modern medicine in Korea and trained the first generation of Korean female doctors.








































































