Medicine
News
01 Jun 2022
Scientists at Osaka Metropolitan University utilized a Japan-developed, objective, and simple nutritional indicator called the Nutrition Risk Index (NRI) to unveil a long-suspected yet unverified relationship between sarcopenia and malnutrition in end-stage kidney disease patients. Their findings confirmed that malnutrition contributes to sarcopenia, which can be detected through NRI.
30 May 2022
A research team led by Hong Kong Baptist University (HKBU) has found that a proteolytic enzyme called membrane-type 1 matrix metalloproteinase (MT1-MMP) plays an important role in the regulatory mechanism of fullness, or satiety, and it could serve as a promising potential drug target for the management of obesity.
25 May 2022
Among anesthetics, ketamine has a unique effect: it also acts as an antidepressant. A research team led by Osaka Metropolitan University Professor Makoto Kondo linked ketamine to brain regulation of IGF-1, which works independently of other ketamine-associated factors. The discovery may help untangle ketamine’s positive and negative effects, allowing future drug development to target IGF-1 directly.
23 May 2022
The antibiotic rifampicin is shown as a potential medicine for preventing Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal dementia (FTD).
19 May 2022
Thought to enhance muscle recovery, compression garments are commonly worn by athletes and people engaging in exercise. Yet, an international research team’s systematic review provides evidence to the contrary.
13 May 2022
Molecular robots work cooperatively in swarms, LED lights made from rice husk, Muonic x-rays safely see inside samples, Making a luminescent material shine brighter and How to counter vaccine hesitancy, Read all in the May Editor's Choice and this month's Asia Research News 2022 magazine pick - Absorbing impact: Inside the Head of a Woodpecker.
27 Apr 2022
A new report by the InterAcademy Partnership (IAP) highlights practical recommendations for improving the uptake of vaccines.
25 Apr 2022
Examination of endangered species’ stem cells unveils ancient genetic links between mammals.
21 Apr 2022
Giants in History: The research of Filipino pharmaceutical chemist Luz Oliveros-Belardo (3 November 1906 – 12 December 1999) focussed on essential oils and other chemicals derived from native Philippine plants.
14 Apr 2022
Bacteria hitchhike on red blood cells, New model simulates effects of exercise on muscles, Argon found in air of ancient atmosphere and Revealing emergent elastic fields of chiral crystals. Read all in the April Editor's Choice and this month's Asia Research News 2022 magazine pick - Asia's race to outsmart antimicrobial resistance.
14 Apr 2022
Giants in History: Filipino chemist and pharmacist Manuel A. Zamora (29 March 1870 – 9 July 1929) is best remembered for his discovery of the tiki-tiki formula to combat beriberi, a disease caused by Vitamin B1 deficiency
10 Apr 2022
Malaysian and UK medical device and composite materials experts have partnered up to research into using natural fibres for prosthetic limb technology to lower the cost of the prosthesis
05 Apr 2022
Researchers have captured images of cells in mice using astronomy technology
04 Apr 2022
Distinguished Professor Hiroki Shirato of Hokkaido University is one of the nine recipients of the Japan Academy Prize in 2022, for his groundbreaking work on “Biomedical and Engineering Research about Real-time Tumor Tracking Radiotherapy/Particle Beam Therapy against Cancer.”
31 Mar 2022
Gene editing technology has been used to pinpoint new molecular targets for treating an aggressive form of leukemia in adults.
25 Mar 2022
Prof. Takashi Takebayashi and his colleague performed a retrospective analysis where they analysed the significance of varied assistance level when using robotic therapy among stroke survivors. They proved that the assistance level needs to be maximised for patients who had severe to moderate stroke whereas the assistance should be minimised for the moderate to mild stroke patients. They stressed on the need for future studies with more objective outcome tools and a larger sample using appropriate research methods.
23 Mar 2022
Researchers have discovered in mice an additional use of globins as an intravenous drug that can delay liver fibrosis progression. Last year, the application of recombinant human cytoglobin (CYGB) as a protein therapeutic agent against liver damage and cirrhosis was published in Hepatology (Hepatology 2021,73:2527-2545) by Professor Norifumi Kawada’s research group. Here, they studied the antifibrotic properties of the globin family members hemoglobin (HB), myoglobin (MB), and neuroglobin (NGB) in comparison with CYGB. All globins demonstrated greater antioxidant capacity than glutathione in cell-free systems. Interestingly, all globins, except HB, could enter the cells and inhibit the collagen synthesis leading to a suppression of fibrosis development both in vitro and in vivo. The study was published in the journal Redox Biology.
16 Mar 2022
Microgravity worms help solve astronaut muscle problems, CO2 recycling and drug development, Remote control of robot hand, Enabling the study of diverse Hepatitis B. Read all in the March's Editor's Choice and even more in the Asia Research News 2022 magazine.
11 Mar 2022
A soft hydrogel could help scientists find treatments for drug-resistant cancer stem cells.
09 Mar 2022
An analysis method for protein–protein interactions using proximity-dependent biotinylation for next-generation drugs
09 Mar 2022
Tests using a mouse model of Alport syndrome suggests that turning off a cell signalling protein may significantly prolong life by preventing kidney scarring.
04 Mar 2022
A recent study in The Lancet provides the most comprehensive understanding of this global health problem to-date.
04 Mar 2022
The Asian Development Bank partnered with global institutions to examine efforts to curb one of humanity’s most significant global health threats.
03 Mar 2022
Asia Research News surveyed institutions in Asia to learn about their latest contributions to antimicrobial resistance research.
02 Mar 2022
A team of researchers at Tohoku University have developed a simple lab-based system for growing human muscle cells that are capable of vigorously contracting.
01 Mar 2022
A novel biomaterial promotes bone tissue regrowth, showing promise for surgical procedures.
25 Feb 2022
Induction into the Hall of Master Academic Clinicians is the highest accolade for clinical faculty at the SingHealth Duke-NUS Academic Medical Centre. Exemplary clinical faculty members are selected by a special committee for their subject matter mastery, academic excellence and exceptional mentoring for Duke-NUS students.
25 Feb 2022
Scientists have developed a prototype sensor that could help doctors rapidly measure adenosine triphosphate (ATP) and lactate levels in blood samples from patients, aiding in the rapid assessment of the severity of some diseases.
24 Feb 2022
Giants in History: Ogino Ginko (3 March 1851 – 23 June 1913) was the first registered female doctor to practise modern medicine in Japan. After contracting gonorrhoea from her first husband and being embarrassed from having to seek medical attention from male doctors, Ginko resolved to become a doctor to help women in similar situations.
22 Feb 2022
A magnetic field could boost blood vessel growth to regenerate damaged tissue.
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Giants in history
Henriette Bui Quang Chieu (1906 – 2012) was inspired to follow in her brother’s footsteps and become a doctor after losing her mother to tuberculosis. She studied in France and became the first Vietnamese woman to receive a medical degree. Upon her return to Vietnam, Bui was appointed head of the Department of Midwifery at Cho Lon Hospital in Ho Chi Minh City. A pioneer in gynaecology, she applied acupuncture techniques that she had learned in Japan to obstetrics. As Vietnam was still a French colony, Bui also lobbied for the rights of Vietnamese doctors, nurses, and patients.
Japanese biochemist Akira Endo (1933 – 2024) discovered the first statin, called mevastatin, which lowered cholesterol levels in the blood by inhibiting a key enzyme in the cholesterol biosynthesis pathway. His work laid the foundation for the development of statins to help patients lower their blood cholesterol levels and reduce their risk of heart disease or stroke.
Filipina paediatrician and scientist Perla Santos-Ocampo (25 July 1931 – 29 June 2012) made important contributions to treatments and policies that curbed debilitating and sometimes deadly diarrhoea-related diseases and malnutrition in children.
Singaporean physician Oon Chiew Seng (1916 – 31 March 2022) advanced dementia care and research in Singapore, and co-founded the Apex Harmony Lodge, the nation’s first nursing home for residents with dementia.
Vietnamese surgeon Tôn Thất Tùng (10 May 1912 – 7 May 1982) developed a pioneering technique that reduced the risks and mortality rate of liver operations.
Michiaki Takahashi (17 February 1928 – 16 December 2013) was a Japanese virologist who developed the first chickenpox vaccine.
Irene Ayako Uchida’s (8 April 1917 – 30 July 2013) strides to understand genetic diseases such as Down syndrome paved the way for early screening of chromosomal abnormalities in foetuses.
Baron Kitasato Shibasaburo (29 January 1856 – 13 June 1931) was a Japanese physician and bacteriologist whose work led to a new understanding of preventing and treating tetanus, diphtheria and anthrax.
Maggie Lim (5 January 1913 – November 1995) was a Singaporean physician who promoted family planning and expanded the access to clinics to improve the quality of life for mothers and children in Singapore’s early days.
By isolating soil microorganisms and studying the compounds they produce, Satoshi Omura (born 1935) discovered almost 500 organic compounds with unique properties that were produced by these microorganisms, including many new antibiotics.
The founder of the Adyar Cancer Institute in India, Muthulakshmi Reddy (30 July 1886 – 22 July 1968), fought to uplift women and girls from impoverished situations.
Chinese-American virologist and molecular biologist Flossie Wong-Staal (27 August 1946 – 8 July 2020) was the first scientist to clone HIV and determine the function of its genes.
Maharani Chakravorty (1937 – 2015) was one of India’s earliest molecular biologists whose research paved the way for advances in the treatment of bacterial and viral infections.
Archana Sharma (16 February 1932 - 14 January 2008) conducted research into plant and human genetics that expanded the understanding of both botany and human health. In relation to botany, she uncovered the means by which asexually-reproducing plants evolve into new species.
The first Thai woman to receive a degree in medicine, Margaret Lin Xavier (29 May 1898 – 6 December 1932), is best remembered for her compassion towards her less privileged patients.
In 1915, pathologist Katsusaburo Yamagiwa and his research assistant Koichi Ichikawa became the first to prove that chronic exposure to chemicals can cause cancer.
In 1915, Koichi Ichikawa along with pathologist Katsusaburo Yamagiwa became the first to prove that chronic exposure to chemicals can cause cancer.
Husband and wife team, Kimishige (3 December 1925 – 6 July 2018) and Teruko Ishizaka (28 September 1926 – 4 June 2019) discovered the antibody class Immunoglobulin E (IgE) that triggers allergic reactions. They also discovered that IgE antibodies attach to white blood cells, known as mast cells, releasing histamine, which causes allergic reactions.
Husband and wife team, Kimishige (3 December 1925 – 6 July 2018) and Teruko Ishizaka (28 September 1926 – 4 June 2019) discovered the antibody class Immunoglobulin E (IgE) that triggers allergic reactions. They also discovered that IgE antibodies attach to white blood cells, known as mast cells, releasing histamine, which causes allergic reactions.
Japanese chemist Takamine Jokichi (3 November 1854 – 22 July 1922) founded the Tokyo Artificial Fertilizer Company, where he isolated a starch-digesting enzyme (named takadiastase) from the fungus Aspergillus oryzae.
Ground-breaking cancer researcher Kamal Jayasing Ranadive (8 November 1917 – 11 April 2001) advanced the understanding of the causes of leukaemia, breast cancer and oesophageal cancer through the use of animal models. She was also among the first to recognise how susceptibility to cancer is linked to tumour-causing interactions between hormones and viruses.
The research of Filipino pharmaceutical chemist Luz Oliveros-Belardo (3 November 1906 – 12 December 1999) focussed on essential oils and other chemicals derived from native Philippine plants.
Thai physician and conservationist Boonsong Lekagul (1907 – 1992) made major contributions to the preservation of his country’s wildlife.
Indian scientist and physician Upendranath Brahmachari (19 December 1873–6 February 1946) is best known for creating a drug called Urea Stibamine, used to safely and reliably treat visceral leishmaniasis (or Kala-azar), a severe infection caused by the Leishmania parasite.
Filipino chemist and pharmacist Manuel A. Zamora (29 March 1870 – 9 July 1929) is best remembered for his discovery of the tiki-tiki formula to combat beriberi, a disease caused by Vitamin B1 deficiency.
Korean parasitologist Seung-Yull Cho (16 November 1943 – 27 January 2019) is remembered largely for his pioneering works to control infections caused by helminthic parasites and his contribution to journal publishing.
Fe Villanueva del Mundo (27 November 1911 – 6 August 2011) was a Filipina paediatrician who founded the Philippines’ first paediatric hospital.
After witnessing death and suffering as a youth in his home village during World War II, Nguyễn Tài Thu (6 April 1931 – 14 February 2021) set his sights on alleviating pain by becoming a doctor. After studying Traditional Chinese Medicine in China in the 1950s, Thu returned to Vietnam to serve in military hospitals. Eventually, he became the country’s foremost practitioner of acupuncture, a technique he first learned by inserting needles into himself.
Minoru Shirota (April 23, 1899 – March 10, 1982) was a Japanese microbiologist who invented the popular fermented drink Yakult.
Wu Lien-teh (10 March 1879 – 21 January 1960) was a Malaysian-born doctor who invented a mask that effectively suppressed disease transmission. Winning the prestigious Queen’s Scholarship enabled Wu to become the first Chinese student to study medicine at the University of Cambridge.
David T. Wong (born 1936) is a Hong Kong-born American neuroscientist who is best known for discovering the antidepressant drug fluoxetine, better known as Prozac.
Indian organic chemist Asima Chatterjee (1917 to 2006) studied the medicinal properties of plant products, especially compounds known as vinca alkaloids.
Tu Youyou (born 30 December 1930) is a Chinese pharmaceutical scientist who was awarded the 2015 Nobel Prize in Physiology or Medicine for her work on extracting artemisin from sweet wormwood to treat malaria.
Chika Kuroda (24 March 1884 – 8 November 1968) was a Japanese chemist whose research focussed on the structures of natural pigments.
Umetaro Suzuki (7 April 1874 – 20 September 1943) was a Japanese scientist best remembered for his research on beriberi, a disease caused by vitamin B1 deficiency, characterized by limb stiffness, paralysis and pain.
Salimuzzaman Siddiqui (19 October 1897 – 14 April 1994) was an artist and chemist from Pakistan whose research focused on natural products from plants.
Barry Paw (29 August 1962 – 28 December 2017) was a biologist and oncologist who discovered several novel genes and their functions in red blood cells.
Syed Qasim Mehdi (13 February 1941 – 28 September 2016) was a Pakistani molecular biologist who was a founding member of the Human Genome Diversity Project (HGDP), which assessed human diversity by studying human migration, mutation rates, relationships between different populations, genes involved in height and selective pressure.
Tsai-Fan Yu (1911 – 2 March 2007) was a Chinese-American physician and researcher who was the first female full professor at Mount Sinai School of Medicine. She discovered that gout, a condition characterized by the painful inflammation of joints, was caused by elevated levels of uric acid in the bloodstream.
Min Chueh Chang (10 October 1908 – 5 June 1991) was a Chinese-American biologist who studied fertilization in mammalian reproduction.
A Japanese surgeon, Tetsuzo Akutsu (20 August 1922 – 9 August 2007) built the first artificial heart capable of keeping an animal alive.
Ogino Ginko (3 March 1851 – 23 June 1913) was the first registered female doctor to practise modern medicine in Japan.
Esther Park (1877-1910), born Kim Jeom-dong, was the first female Korean physician to practise modern medicine in Korea and trained the first generation of Korean female doctors.