Science

Researchers at the Institute of Industrial Science, The University of Tokyo, use artificial intelligence to help interpret data generated by material science spectroscopy experiments, which can aid in the development of new drugs and organic conductors.

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A research group led by Osaka University has found that plant cells may be able to detect mechanical forces to determine their own position within the leaf—whether they are on the surface or in the inner tissues—and therefore differentiate into appropriate cell types after damage. These findings reveal how plants regenerate the correct type of tissues when damaged, and may improve our understanding of the mechanisms underlying the high regeneration potential of plants.

Researchers at Kanazawa University report in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) high-speed atomic force microscopy experiments that show how ligands associated with stimulating and suppressing activation of the TRPV1 protein increase and decrease the molecule’s structural variations. The observations provide insights into how these heat- and chilli-sensing proteins function.

Researchers at Osaka University discovered a new class of photo-responsive crystal compounds, heteroaromatic 1,2-diketones. Certain light irradiation causes the crystals in these materials to melt, dramatically changing the materials’ properties. One member of this class, SO, shows luminescent changes while melting, which enabled the research team to visualize the crystal-melting process at the molecular level. These findings provide fundamental insights into the mechanisms behind crystal melting and will enable future designs of light-responsive materials.

Researchers at Kanazawa University report in Nano Letters how high-speed atomic force microscopy leads to insights into processes relevant to Alzheimer’s disease. Moreover, the technique is shown to be an excellent tool for studying the effect of drugs against the disease.

Understanding how catalytic organic polymers emerged on prebiotic Earth is vital to understanding the origin of life. Now, a team of scientists at Tohoku University have recently found a potential environment for the reaction that produced catalytic organic polymers.

A protein that helps bats survive viral diseases might offer lessons for developing new anti-inflammatory treatments.

Researchers from Osaka University identified a new protein, R-spondin 3 (RSPO3), that has beneficial effects after ischemic stroke in mice. Specifically, RSPO3 activates the protein LGR4 to trigger a cascade of cellular reactions that decreases inflammation and stimulates the growth of neuronal extensions. Moreover, administrating RSPO3 to mice one day after stroke improved recovery of sensory and motor functions. These findings provide a new target for developing treatments to improve recovery after ischemic stroke.

Researchers from Osaka University identified a new protein, NICOL, and described its crucial role in the maturation of sperm, which itself is necessary for male fertility. Mice who lacked this protein were sterile. Such a discovery may have implications for the development of male contraceptives.

A new drug delivery system delivers an antioxidant directly to mitochondria in the liver, mitigating the effects of oxidative stress.

Osaka Metropolitan University scientists elucidated the molecular structure of anionic Pt(0) complexes for the first time in collaboration with co-researchers at Paul Sabatier University - Toulouse III. The key to success is the stabilization of anionic Pt(0) complexes (which are usually unstable owing to their electron-donating nature) by the electron-accepting properties of boron compounds. The results of this research allow us to elucidate the properties and functions of highly active chemical species and provide new guidelines for their creation. The research is expected to lead to the development of innovative catalytic reactions mediated by these chemical species.

Zinc-air batteries may power the future thanks to their high density, low cost, and nature-friendly makeup. Yet, their low voltage has stymied their widespread application. Now, a research group has realized a zinc-air battery with an open circuit voltage of over 2 V.

Scientists from A*STAR’s Genome Institute of Singapore (GIS) have ascertained that there is no stable microbial community residing in the bloodstream of healthy humans. This is an important discovery as blood donations are a crucial part of medical practice. Understanding the types of microbes that are found in blood could allow for the development of better microbial tests in blood donations, which would minimise the risk of transfusion-related infections. The research was published in Nature Microbiology on 31 March 2023.

A joint research group at Osaka Metropolitan University has succeeded in regulating the flow of single molecules in solution by opening and closing the nanovalve mounted on the nanofluidic device by applying external pressure. The research group fabricated a device with a ribbon-like, thin, soft glass sheet on the top, and at the bottom a hard glass substrate having nanochannels and nanovalve seats. By applying external pressure to the soft glass sheet to open and close the valve, they succeeded in directly manipulating and controlling the flow of individual molecules in solution. They also observed an effect of fluorescence signal amplification when single fluorescent molecules are confined in the tiny nanospace inside the valve. The effect can be ascribed to the nanoconfinement, which suppresses the random motion of the molecules.

Allowing the direct observation of biomolecules in dynamic action, high-speed AFM has opened a new avenue to dynamic structural biology. An enormous amount of successful applications within the last 15 years provide unique insights into essential biological processes at the nanoscale – visualizing, for example, how molecular motors execute their specific functions.

An Osaka Metropolitan University scientist published a review article on numerous asymmetric reactions using arynes, organized by style, and detailed their outline and characteristics. Unresolved issues and prospects in this field were also described.

Researchers at the Institute of Industrial Science, The University of Tokyo, have developed a desktop charger with voltages high enough to replenish the electric charge on N95 and surgical masks, which is required for effective use

Researchers from The University of Tokyo find a new approach to successfully identify areas at risk of flooding that can be missed by historical hazard maps.

The Nobel prize winning physicist Niels Bohr once said, “An expert is a (person) that has made all the mistakes that can be made in a narrow field.” This idea that to master a skill we must learn from our mistakes and avoid making them in future has long been recognized; however, the brain mechanisms and pathways that control this ability have been poorly understood. We revealed a specific brain pathway that allows us to identify and learn from our mistakes to guide better decision-making in future. Our work is an important step towards understanding how the brain controls our daily choices and behavior. The identification of these cells as ‘mistake signalers’ may also help to guide new treatments for mental health conditions associated with impaired decision-making ability.

Researchers at the Institute of Industrial Science, The University of Tokyo use isotopically purified graphite to study the phenomenon of heat flowing like a fluid, which can lead to new heat-sink devices for electronics.

In the quantum world particles can instantaneously know about each other’s state, even when separated by large distances. This is known as nonlocality. Now, A research group has produced some interesting findings on the Hardy nonlocality that have important ramifications for understanding quantum mechanics and its potential applications in communications.

A research group at Osaka Metropolitan University has succeeded in selectively recovering trace rare earth elements in synthetic seawater and environmental water, such as hot spring water, using baker’s yeast with a phosphate group added. The phosphorylated yeast is expected to be utilized as a material for recovering useful metals and removing toxic metals, thereby contributing to the realization of a metal resource-circulating society.

Osaka Metropolitan University scientists have developed a theory to experimentally determine differences in nuclear structure. Using this method to assess carbon and oxygen nuclei revealed that they contain more components in their cluster structure than in their shell structure. This enables visualization of nuclear structures without large-scale numerical calculations, which are expected to be applied to heavier nuclei in the future. This suggests that the method could be used to solve the ultimate question in nuclear physics: where did the elements we see around us come from?”

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A tiny platform empowers scientists to examine how gut and liver cells interact in health and disease.

An international interdisciplinary team of researchers hailed from India, Malaysia, Singapore and Thailand has successfully developed a method of using chitosan from terrestrial insects to manufacture eco‐friendly polymer composite parts using the 3D printing method.

Researchers from the Institute of Industrial Science, The University of Tokyo, find that a deep-learning model that simultaneously learns to classify satellite data as rain/no-rain while determining rain intensity outperforms other models.

Osaka Metropolitan University scientists analyzed each element of the neutrino mass matrix belonging to leptons and showed theoretically that the intergenerational mixing of lepton flavors is large. Furthermore, by using the mathematics of random matrix theory, the research team was able to prove, as much as is possible at this stage, why the calculation of the squared difference of the neutrino masses are in close agreement with the experimental results in the case of the seesaw model with the random Dirac and Majorana matrices. The results of this research are expected to contribute to the further development of particle theory research, which largely remains a mystery.

Researchers from Osaka University found that the COMMD3/8 complex is implicated in the progression of the autoimmune response in a mouse model of rheumatoid arthritis. They identified celastrol, the active compound of a medicinal herb, as an inhibitor of the COMMD3/8 complex. Celastrol blocked the progression of rheumatoid arthritis. Thus, celastrol is a potential lead for developing treatments against rheumatoid arthritis.