Science

A New Approach for Peripheral Annelation of Porphyrinoid

Researchers from Osaka University have revealed the mechanism by which increased signaling through a pathway associated with a molecule called Wnt leads to the development of liver cancer. They identified a gene called GREB1 as a target of Wnt specifically in liver cancer. This gene alters the function of a protein called HNF4α, leading to the development of cancer. They also showed that treatment of mice with antisense oligonucleotides against GREB1 had significant anti-cancer effects.

An international team led by Professor Yan Xu from Osaka Metropolitan University has developed a groundbreaking nanofluidic device, named NANa, capable of stochastically capturing and digitally detecting individual proteins at cellular concentrations. This tool, vital for precision medicine, is designed to handle tiny volumes equivalent to a single cell's contents and can identify single biomolecules even in high-concentration environments. The team plans to conduct further demonstrations using actual cell samples and explore the integration of this tool with AI and biological big data. This research could potentially revolutionize personalized disease prevention and treatment.

Researchers from Newcastle University, led by Dr Kheng Lim Goh, have developed a cost-effective Cellular Automata (CA) model for predicting marine plastic movement. Findings from model predictions align well with traditional particle-tracking models, suggesting its potential as a valuable tool for assessing marine plastic pollution and mitigation strategies.

An international team of researchers revisited the fundamentals of Negative Poisson's ratio structure (NPRS) and investigated its creation using laminated carbon fiber reinforced plastics, a strong and lightweight material. Their objective was to gain a deeper understanding of the process and explore potential applications, aiming to unlock new possibilities and advancements in the field of materials science for sustainability.

Osaka Metropolitan University researchers succeeded, for the first time, in stabilizing the high-temperature phase of Li3PS4—a solid electrolyte material¬¬—thus attaining high ionic conductivity even at room temperature, using a method of rapid heating during its crystallization. This unprecedented achievement is expected to contribute to the development of materials for all-solid-state batteries with higher performance.

Researchers from Osaka University found that the binding of two proteins—Polydom and Tie1—is essential for lymphatic cell migration in the remodeling of lymphatic vessels, which transport molecules around the body. A better understanding of the development and remodeling of the lymphatic system will lead to better therapeutic options for diseases such as lymphedema, which is common in cancer patients and currently has no cure.

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A team of researchers from universities in Thailand and Malaysia have collaborated to develop a unique kind of bioplastic sheet that is good for the environment and can decompose naturally. They made this bioplastic sheet using a byproduct of the bromelain industry which used the leftover pineapple stems from agricultural waste. This new type of bioplastic sheet has the potential to be used as single-use packaging material, as an alternative to the use of harmful plastic sheet, contributing to a more sustainable way of doing business and promoting a circular economy.

A physicist from the University of the Philippines – Diliman College of Science National Institute of Physics (UPD-CS NIP) led a team of researchers in pioneering a way to make a special kind of “dark” matter that can’t be observed using standard laboratory methods.

Tam Pà Ling, a cave in northern Laos, reveals new secrets about our earliest human journeys from Africa through to Australia.

Osaka Metropolitan University scientists synthesized a novel molecule by combining dynamic covalent reactions based on organic radicals and coordination reactions. They found that the two types of reactions do not inhibit each other. Their results suggest the possibility of synthesizing materials by combining different types of reactions, which is expected to lead to the construction of structures that have never existed before.

Water from the Pacific Ocean flows into the Indian Ocean via the Indonesia Archipelago thanks to a vast network of currents that act as a conveyor belt, transporting warmth and nutrients. Currents can sometimes form circular motions and these are known as eddies. An international group of researchers has modeled the impacts of eddies on the currents that carry water from the Pacific Ocean to the Indian Ocean.

A team led by researchers from Osaka University elucidated a molecular mechanism that is crucial for separating genetic material into daughter cells during cell division. A protein called CENP-C is part of a complex called the kinetochore, which supports the movement of chromosomes. Two portions of CENP-C, the CCAN-binding domain and Cupin domain, are needed for CENP-C to function. The Cupin domain repeats itself through oligomerization, which is essential for proper CENP-C function.

Scientists from Thailand, France and Singapore have conducted groundbreaking research using both tiny cellulose nanofibers (CNF) and long pineapple leaf fibers (PALF) to create stronger materials. They added varying amounts of CNF to epoxy and found that 1% CNF greatly increased impact strength. PALF-epoxy composites showed significant flexibility and strength improvements. Combining CNF and PALF resulted in a remarkable increase in impact strength. The findings could revolutionize stronger material development.

Ultrafast fluorescent imaging technology brings the molecular dynamics of living cells into clear view.

Researchers from Osaka University developed an in vivo CRISPR screen to analyze factors affecting Toxoplasma gondii fitness in healthy and immunodeficient mice. Mice were infected with Toxoplasma containing CRISPR libraries that targeted specific genes; genetic sequencing was then performed to identify which genes are important to fitness. The genetic screen clarified the contributions of host genetics and parasite genetics and can contribute to the development of strategies for toxoplasmosis treatment and prevention.

Fragments of spherical ‘Buckyball’ molecules have stable electron-accepting ability with great practical potential.

Osaka Metropolitan University scientists investigated numerically the interaction between a quantized vortex and a normal-fluid. Based on the experimental results, researchers decided the most consistent of several theoretical models. They found that a model that accounts for changes in the normal-fluid and incorporates more theoretically accurate mutual friction is the most compatible with the experimental results.

Tests could soon identify patients who will respond well to the available treatment for chronic myeloid leukaemia and those who will be resistant to it—which could improve their chances of survival.

A research team, led by researchers from Osaka University, performed genetic screening of fission yeast lacking DNA repair gene Rad51 to identify genes that play a role in gross chromosomal rearrangement (GCR), a type of mutation that occurs at the centromere. Cells lacking Srr1 or Skb1 exhibited reduced GCR, indicating that these genes are important to the occurrence of GCR. These findings advance our understanding of the mechanisms underlying centromeric GCR.

Eating fermented foods might be the secret to a healthy and long-lived society

A group of researchers from universities in Thailand and Malaysia have collaborated to develop a unique kind of film that is good for the environment and can decompose naturally. They made this film using leftover pineapple stems, which helps reduce the use of harmful plastic films. This new film has the potential to be used as packaging material, contributing to a more sustainable way of doing business and promoting a circular economy.

With the use of electric vehicles and grid-scale energy storage systems on the rise, the need to explore alternatives to lithium-ion batteries has never been greater. Tohoku University researchers have recently developed a prototype calcium metal rechargeable battery capable of 500 cycles of repeated charge-discharge - the benchmark for practical use. The breakthrough was made thanks to the development of a copper sulfide nanoparticle/carbon composite cathode and a hydride-based electrolyte.

Researchers from the Institute of Industrial Science, The University of Tokyo, discover how certain colloids can form a solid-like gel and reveal how the mechanism differs from glasses.

Researchers at the Institute of Industrial Science, The University of Tokyo, use artificial intelligence to help interpret data generated by material science spectroscopy experiments, which can aid in the development of new drugs and organic conductors.

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A research group led by Osaka University has found that plant cells may be able to detect mechanical forces to determine their own position within the leaf—whether they are on the surface or in the inner tissues—and therefore differentiate into appropriate cell types after damage. These findings reveal how plants regenerate the correct type of tissues when damaged, and may improve our understanding of the mechanisms underlying the high regeneration potential of plants.

Researchers at Kanazawa University report in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) high-speed atomic force microscopy experiments that show how ligands associated with stimulating and suppressing activation of the TRPV1 protein increase and decrease the molecule’s structural variations. The observations provide insights into how these heat- and chilli-sensing proteins function.

Researchers at Osaka University discovered a new class of photo-responsive crystal compounds, heteroaromatic 1,2-diketones. Certain light irradiation causes the crystals in these materials to melt, dramatically changing the materials’ properties. One member of this class, SO, shows luminescent changes while melting, which enabled the research team to visualize the crystal-melting process at the molecular level. These findings provide fundamental insights into the mechanisms behind crystal melting and will enable future designs of light-responsive materials.