Science

Researchers from SANKEN (The Institute of Scientific and Industrial Research), at Osaka University developed an optical sensor consisting of carbon nanotube photodetectors and organic transistors formed on an ultrathin, flexible polymer film. A wireless system reads the images from the sensor. Experiments showed the sensor has high sensitivity, a wide bandwidth, and robustness to extreme deformation such as bending and crumpling. This sensor has high potential for use in applications such as non-destructive imaging, non-sampling liquid quality evaluation, wearable devices, and soft robotics.

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The Hayabusa2 mission that collected samples from the asteroid Ryugu has provided a treasure trove of insights into our solar system. After analyzing samples further, a team of researchers have unearthed evidence that cometary organic matter was transported from space to the near-Earth region.

A water-soluble, luminescent europium complex enables evaluation of malignancy grade in model glioma tumor cells.

Temperature-controlled, reversible shifting of molecular gear motion in a solid crystal opens new possibilities for material design.

A research group led by Osaka Metropolitan University has discovered significant nonreciprocal optical absorption of LiNiPO4, referred to as the optical diode effect, in which divalent nickel (Ni2+) ions are responsible for magnetism, by passing light at shortwave infrared wavelengths used in optical communications. Furthermore, they have uncovered that it is possible to switch the optical diode effect by applying a magnetic field. This is a step forward in the development of an innovative optical isolator that is more compact and can control light propagation, replacing the conventional optical isolators with complex structures

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nature Communications a high-speed atomic force microscopy study of the structural dynamics of sodium ion channels in cell membranes. The findings provide insights into the mechanism behind the generation of cell-membrane action potentials.

Non-Heisenberg-type approximant crystals have many interesting properties and are intriguing for researchers of condensed matter physics. However, their magnetic phase diagrams, which are crucial for realizing their potential, remain completely unknown. Now, for the first time, a team of researchers has constructed the magnetic phase diagram of a non-Heisenberg Tsai-type 1/1 gold-gallium-terbium approximant crystal. This development marks a significant step forward for quasicrystal research and for the realization of magnetic refrigerators and spintronic devices.

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nano Letters how the flexibility of a protein hinge plays a crucial role in the transfer of proteins in key cell processes.

Researchers from Osaka University have discovered a novel treatment to relieve cytokine release syndrome (CRS), a life-threatening inflammation triggered by a serious infection or severe burn. Treatment with a short-acting antibody reduces the inflammatory effects of interleukin-6, a key cytokine in CRS while avoiding the side effects associated with previous longer-acting therapies.

Researchers from Osaka University and collaborating partners have improved the efficiency of heat-to-electricity conversion in gallium arsenide semiconductor microstructures. By judicious spatial alignment of electrons within a two-dimensional electron gas system with multiple subbands, one can substantially enhance the power factor compared with previous iterations of analogous systems. This work is an important advance in modern thermoelectric technology and will benefit the global integration of the Internet of Things.

Researchers from Osaka University have simplified the operation of an important class of chemical transformation: synthesis of beta-lactams, the intricate scaffold of many antibiotics. Their experimental protocol minimizes the toxicity that is a common feature of similar Fischer-carbene synthetic methodologies, and was used to synthesize the scaffold of the thienamycin antibiotic in high yield. This work is an important advancement in sustainable chemistry that should benefit drug development and other chemical syntheses.

Researchers from Osaka University and collaborating partners have helped minimize the cost of an important class of chemical transformations: converting nitriles into primary amines. Their experimental protocol uses a cheap nickel catalyst instead of an expensive noble metal, is convenient to conduct, and works for a broad range of starting materials. This work is an important advance in sustainable chemistry that might help lower the cost of producing nylon and many other everyday products.

Research by Assistant Professor Edison Ang Huixiang and his team from National Institute of Education/Nanyang Technological University Singapore

Unleashing stem cells from dog urine, Electronic Tongue, Tapping into human motion energy, How neurons network, and A radical use for plastic bags. Plus Communicating science two decades on. Read all in the latest Editor's Choice.

Researchers at the Institute of Industrial Science, The University of Tokyo create customizable polymer molds to produce cost-effective arrays of microneedles that can be used to uniquely identify pets with alphanumeric symbols instead of tags or collars.

Researchers from Osaka University found that CD4+ T cells can be classified into 18 categories and 12 distinct gene programs, and that characteristic changes in CD4+ T cell profiles are associated with autoimmune disease, sex, and aging. Analysis of these distinctive immune cell profiles could be used to predict autoimmune disease in the future, paving the way for precision medicine.

Researchers from SANKEN (The Institute of Scientific and Industrial Research), at Osaka University, Shizuoka Institute of Science & Technology, and collaborating partners have resolved a problem that has limited the environmental sustainability of peracid synthesis. By judicious choice of the solvent and light input, approximately room-temperature autoxidation of aldehydes proceeds in a manner that results in industrially useful peracids or carboxylic acids. This work is an important advance in green chemistry that will help minimize the carbon footprint of the chemical industry.

A research team from Osaka University, The University of Tokyo, and Tokyo Institute of Technology revealed the microscopic origin of the large magnetoelectric effect in interfacial multiferroics composed of the ferromagnetic Co2FeSi Heusler alloy and the piezoelectric material. They observed element-specific changes in the orbital magnetic moments in the interfacial multiferroic material using an X-ray Magnetic Circular Dichroism (XMCD) measurement under the application of an electric field, and they showed the change contributes to the large magnetoelectric effect. The findings provide guidelines for designing materials with a large magnetoelectric effect, and it will be useful in developing new information writing technology that consumes less power in spintronic memory devices. The research results will be shown in an article, “Strain-induced specific orbital control in a Heusler alloy-based interfacial multiferroics” published in NPG Asia Materials.

What actually happens is much weirder, and may help us understand more about quantum mechanics

Transmitting an effect known as a domino reaction using redox chemistry has been achieved for the first time.

Researchers from Osaka University and collaborating partners have, via reductive amination, resolved a problem that has limited the applicability of carboxylic acids to alkylamine production. Their experimental protocol is environmentally sustainable, simple and convenient to conduct, and works for a broad range of starting materials. This work is an important advance in green chemistry that might help minimize the environmental footprint of synthesizing a class of molecule that's used to manufacture many everyday products.

A team of researchers has developed an innovative method to design complicated all-α proteins, characterized by their non-uniformly arranged α-helices as seen in hemoglobin. Employing their novel approach, the team successfully created five unique all-α protein structures, each distinguished by their complicated arrangements of α-helices. This capability holds immense potential in designing functional proteins.

Researchers from Osaka University have shown that a protein called HKDC1 is a new target of another protein, TFEB, and plays key roles in maintaining the stability of both mitochondria and lysosomes. HKDC1 is essential for mitophagy to remove damaged mitochondria, and mediates mitochondria–lysosome contact, which is critical for lysosomal repair. The role of HKDC1 in maintaining the stability of these organelles counteracts cellular senescence, revealing HKDC1 as a potential therapeutic target for age-related diseases.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are a dragon-like robot that can fight fires, how having a pet can avoid cognitive decline, and how an illusion can help us learn motor skills.

In a phase 2 trial, researchers from Osaka University have found that erythromycin, a commonly used antibiotic, has acceptable safety and tolerability profiles in patients with myotonic dystrophy type 1. This common form of muscular dystrophy currently has no cure, and the research team is hopeful that phase 2b and 3 trials will further reveal the efficacy of erythromycin as a treatment—at least in some patients.

Researchers employ common plastics to kickstart radical chain reactions, creating a way to reuse plastic waste while improving process safety and efficiency.

Scientists at Osaka Metropolitan University have developed an efficient, non-invasive, and pain-free method to generate canine-induced pluripotent stem cells (iPSCs). They identified six reprogramming genes that can boost canine iPSC generation by 120 times compared to conventional methods using fibroblasts. The iPSCs were created from urine-derived cells without the need for feeder cells, an impossible feat until now. Their findings are expected to advance regenerative medicine and genetic disease research in veterinary medicine.

Researchers from Osaka University have shown that the rare D-form of the amino acid alanine shows a clear circadian rhythm, and is able to affect the circadian clock and regulate gluconeogenesis, a method of glucose release, in the kidney. D-alanine upregulates genes linked to both gluconeogenesis and the circadian rhythm through the circadian transcriptional network. D-alanine is linked to many metabolic and immunological diseases, and this mechanistic insight could potentially lead to novel therapeutic approaches.

A research team at Osaka Metropolitan University has fabricated a gallium nitride (GaN) transistor using diamond, which of all natural materials has the highest thermal conductivity on earth, as a substrate, and they succeeded in increasing heat dissipation by more than two times compared with conventional transistors. The transistor is expected to be useful not only in the fields of 5G communication base stations, weather radar, and satellite communications, but also in microwave heating and plasma processing.