Japan

Machine learning algorithms allow analysis and characterization of the atomic arrangement of silicon surface superstructures without the need for human expertise.

Two novel hypotheses address the “two-fold cost of sex”: one of the biggest enigmas in the evolution of sexual reproduction.

Scientists at Tokyo Medical and Dental University have discovered a new type of bone repairing material that could be used to more precisely fix bone defects.

An international collaboration is developing coating materials that could make windows better insulators.

The first-ever molecular catalyst specifically tailored for mechanochemical reaction conditions enables high-efficiency transformations at near room temperature.

Osaka Metropolitan University researchers have used 100 seconds of laser irradiation to generate convection currents that selectively accelerate biochemical reactions—due to the photothermal effect—by concentrating biofunctional molecules at the cell surface. Using this method, useful molecules can be transported into cells at concentrations a hundred to a thousand times lower than with conventional methods. Furthermore, they also succeeded in selectively introducing small molecules into intracellular organelles usually impossible at low concentrations (hundreds of pmol/L) as well as inducing cell death in targeted cells by concentrating anticancer active peptides into them at concentrations so low that they would not be conventionally effective (several tens of nmol/L).

Researchers at Kanazawa University report in Nano Letters the discovery of a biomolecular dynamical process likely relevant to gene expression. The process, revealed by means of high-speed atomic force microscopy, involves DNA and its packaging molecules.

Researchers from Osaka University found that Ca2+ signaling simultaneously performed signal amplification and olfactory adaptation. The results demonstrated that this mysterious phenomenon was segregated inside the cilium. A novel system was used to observe changes in Ca2+ dynamics inside the thin structure of a cilium. Unveiling the mystery of Ca2+ signaling segregation further clarifies the mechanisms underlying the human sense of smell.

Brain shrinkage patterns tied to low trust have links to depression vulnerability that can alert to its early detection even before symptoms appear.

Lipid nanoparticles have been used to encapsulate CRISPR-Cas9 and deliver it to cells in mice, where it was highly effective at knocking down expression of a target protein.

An international research team has discovered the first example of a supernova, known as SN 2018ivc, showing an unprecedented rebrightening at millimeter wavelengths about one year after the explosion. With the help of the Atacama Large Millimeter/submillimeter Array -- or ALMA -- the analysis revealed that the dying massive star ejected a large amount of its envelope due to a strong binary interaction with a companion star that took place about 1500 years before the explosion. In a paper published in The Astrophysical Journal Letters, the team posits that this rebrightening event in SN 2018ivc provides a missing link between supernovae -- or SN -- that occur in binary star systems and those that involve solitary massive stars.

Osaka Metropolitan University scientists identified about 140,000 molecular clouds in the Milky Way Galaxy from large-scale data of carbon monoxide molecules, observed in detail by the Nobeyama 45-m radio telescope. Using artificial intelligence, the researchers estimated the distance of each of these molecular clouds to determine their size and mass, successfully mapping the distribution of the molecular clouds in the Galaxy in the most detailed manner to date.

A collaborative research group from Tohoku University and the Toyohashi University of Technology has invented a new and efficient method to create metallic plasmas from solid metals under a strong magnetic field in a microwave resonator.

A research group from the Osaka Metropolitan University Graduate School of Medicine conducted a survey of 285 patients regarding the long-term aftereffects of COVID-19. As a result, they revealed that more than half of COVID-19 patients still had residual symptoms, even close to a year afterward. It became clear that fatigue, abnormalities in senses of taste and smell, hair loss, and sleep disorders could persist, regardless of the severity of the initial COVID-19.

Researchers at Kanazawa University report in Angewandte Chemie International Edition how the formation and deformation speed of interlocked molecular structures called rotaxanes can be tuned — a discovery that may lead to an enhanced functionality of rotaxanes as building blocks for molecular machines.

Synthetic hydrogels were shown to provide an effective scaffold for neuronal tissue growth in areas of brain damage, providing a possible approach for brain tissue reconstruction.

Researchers from Osaka Metropolitan University have developed principles and technologies of nanofluidic devices to freely manipulate nanomaterials, biomaterials, and molecules at the single-molecule level using fundamental technologies such as nanofluidic processing, functional integration, and fluidic control and measurement, which has pioneered the way to integrate various fields under nanofluidics.

An effective, stable solid-state electrochemical transistor has been developed, heralding a new era in thermal management technology.

Sifting through sewage for SARS-CoV-2 genetic material could help authorities tailor infection control policies.

Osaka Metropolitan University scientists found that 2-oxo-imidazole-containing dipeptides (2-oxo-IDPs) exhibit very high antioxidant activity. Furthermore, they established a method to selectively and sensitively detect very small amounts of 2-oxo-IDPs and revealed for the first time that several types of 2-oxo-IDPs are contained in meat, including beef, pork, and chicken.

To clarify the mechanism of serial dependence in number perception, a research team from Osaka Metropolitan University conducted two tests, independently asking subjects to estimate the number of coins, or to estimate the value of those coins, shown on-screen for half a second. The results showed that serial dependence was confirmed in both tasks and that the most significant effect on serial dependence was not caused by the last stimuli, but the subjects last response. These results indicate that higher-order cognitive processing has a greater influence on the occurrence of serial dependence.

In hepatic steatosis, hepatocytes "die," resulting in liver damage. Severe steatosis increases hepatocellular deaths, thus aggravating liver damage. The mechanism is unclear. Using mice, we show that mild steatosis causes apoptosis whereas severe steatosis predominantly causes necroptosis leading to cell rupture. This induces strong inflammation and new cell death, producing further liver damage. We reveal the transcription factor ATF3 to be involved in this process. Our results are expected to contribute to therapeutic method development.

A research group from the Graduate School of Engineering at Osaka Metropolitan University has shown that 3C-SiC exhibits high thermal conductivity equivalent to the theoretical value, based on thermal conductivity evaluation and atomic-level analysis, for the first time. They demonstrated that a 3C-SiC film on silicon substrate had a high thermal conductivity and expect that fabricating large-diameter wafers can be achieved at a low cost. The discovery should lead to improved heat dissipation in everyday electronic devices.

Team studies discrimination, mental distress, and work impairment in COVID-19 survivors.

Researchers from Osaka University have shown sex-specific differences in the immune response to COVID-19 infection. By identifying and analyzing the immune cell population in COVID-19 patients, they showed that infection results in a reduced ratio of circulating follicular T regulatory (cTfr) cells to a network of antibody-producing proteins, correlated with dysregulated antibody production. This cTfr cell reduction is more significant in males, providing cellular evidence for the observed association between increased risk and male sex.

Hydrothermal vents have been identified as a previously undiscovered source of dissolved black carbon in the oceans, furthering the understanding of the role of oceans as a carbon sink.

Osaka Metropolitan University scientists have demonstrated that fish can recognize “it’s me” when they themselves in a picture for the first time in non-human animals. Further testing made it clear that the fish recognize their own face in the pictures like humans.

A research group at Osaka Metropolitan University has derived a new evaluation method for the measuring the size X-ray microbeams (diameter) through mathematical analysis. The group then verified the validity of the mathematically derived evaluation method by measuring the diameter of X-ray microbeams using metal wires of various diameters with an X-ray fluorescence analysis system for small areas and found that it was possible to calculate the beam diameter more accurately than the previous conventional evaluation method.

Hokkaido University researchers have developed a novel method to design and develop peptide antibiotics in large numbers, which will prove critical to controlling antibiotic resistance.

Two catalysts working in tandem enable inexpensive formate salts to perform difficult dearomative reactions, giving products potentially useful for drug development.